(13 nodes) (1976) Aryl 4-monooxygenase and cytochrome P-450 in the aorta: possible role in atherosclerosis. network (Callithrix jacchus)

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Your Input:
	LOC100415600	Uncharacterized protein; Belongs to the cytochrome P450 family. (527 aa)
	CYP2D19	Cytochrome P450 2D19; Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. (497 aa)
	CYP2C76	Cytochrome P450 2C76; Belongs to the cytochrome P450 family. (489 aa)
	CYP2J2	Cytochrome P450 family 2 subfamily J member 2; Belongs to the cytochrome P450 family. (477 aa)
	CYP1A1	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (512 aa)
	CYP1A2	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] (516 aa)
	CYP2S1	Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family. (503 aa)
	CYP4Z1	Cytochrome P450 family 4 subfamily Z member 1; Belongs to the cytochrome P450 family. (505 aa)
	CYP3A21	Cytochrome P450 3A21; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (527 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (548 aa)
	CYP4X1	Cytochrome P450 family 4 subfamily X member 1; Belongs to the cytochrome P450 family. (509 aa)
	CYP4F12	Cytochrome P450 family 4 subfamily F member 12; Belongs to the cytochrome P450 family. (526 aa)
	CYP2A13	Cytochrome P450 family 2 subfamily A member 13; Belongs to the cytochrome P450 family. (494 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP1A1	CYP1A2	ENSCJAP00000032652	ENSCJAP00000032736	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	0.946
CYP1A1	CYP1B1	ENSCJAP00000032652	ENSCJAP00000055041	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	0.937
CYP1A1	CYP2A13	ENSCJAP00000032652	ENSCJAP00000076429	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 2 subfamily A member 13; Belongs to the cytochrome P450 family.	0.936
CYP1A1	CYP2C76	ENSCJAP00000032652	ENSCJAP00000029395	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 2C76; Belongs to the cytochrome P450 family.	0.923
CYP1A1	CYP2D19	ENSCJAP00000032652	ENSCJAP00000004200	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 2D19; Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes.	0.934
CYP1A1	CYP2S1	ENSCJAP00000032652	ENSCJAP00000037342	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family.	0.926
CYP1A1	CYP3A21	ENSCJAP00000032652	ENSCJAP00000047441	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 3A21; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.961
CYP1A1	CYP4F12	ENSCJAP00000032652	ENSCJAP00000073760	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 4 subfamily F member 12; Belongs to the cytochrome P450 family.	0.513
CYP1A1	CYP4X1	ENSCJAP00000032652	ENSCJAP00000061323	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 4 subfamily X member 1; Belongs to the cytochrome P450 family.	0.403
CYP1A1	CYP4Z1	ENSCJAP00000032652	ENSCJAP00000039512	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 4 subfamily Z member 1; Belongs to the cytochrome P450 family.	0.406
CYP1A1	LOC100415600	ENSCJAP00000032652	ENSCJAP00000004177	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.922
CYP1A2	CYP1A1	ENSCJAP00000032736	ENSCJAP00000032652	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family.	0.946
CYP1A2	CYP1B1	ENSCJAP00000032736	ENSCJAP00000055041	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	0.959
CYP1A2	CYP2A13	ENSCJAP00000032736	ENSCJAP00000076429	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Cytochrome P450 family 2 subfamily A member 13; Belongs to the cytochrome P450 family.	0.950
CYP1A2	CYP2C76	ENSCJAP00000032736	ENSCJAP00000029395	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Cytochrome P450 2C76; Belongs to the cytochrome P450 family.	0.937
CYP1A2	CYP2D19	ENSCJAP00000032736	ENSCJAP00000004200	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Cytochrome P450 2D19; Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes.	0.419
CYP1A2	CYP2J2	ENSCJAP00000032736	ENSCJAP00000029694	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Cytochrome P450 family 2 subfamily J member 2; Belongs to the cytochrome P450 family.	0.936
CYP1A2	CYP2S1	ENSCJAP00000032736	ENSCJAP00000037342	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family.	0.931
CYP1A2	CYP3A21	ENSCJAP00000032736	ENSCJAP00000047441	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Cytochrome P450 3A21; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.964
CYP1A2	CYP4F12	ENSCJAP00000032736	ENSCJAP00000073760	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Cytochrome P450 family 4 subfamily F member 12; Belongs to the cytochrome P450 family.	0.535