STRINGSTRING
RPA3 RPA3 FAAP100 FAAP100 POLI POLI RPA1 RPA1 ATR ATR MUS81 MUS81 ATRIP ATRIP FANCB FANCB REV3L REV3L POLH POLH UBE2T UBE2T WDR48 WDR48 FANCI FANCI BRCA1 BRCA1 TELO2 TELO2 EME2 EME2 PMS2 PMS2 FANCE FANCE ERCC4 ERCC4 RMI2 RMI2 FANCD2 FANCD2 FAN1 FAN1 BRCA2 BRCA2 EME1 EME1 SLX4 SLX4 TOP3B TOP3B RAD51 RAD51 FANCF FANCF RMI1 RMI1 USP1 USP1 FANCM FANCM BLM BLM TOP3A TOP3A RPA2 RPA2 LOC100385843 LOC100385843 FAAP24 FAAP24 APITD1 APITD1 FANCL FANCL POLK POLK HES1 HES1 MLH1 MLH1 ENSCJAP00000071556 ENSCJAP00000071556 FANCG FANCG PALB2 PALB2 ERCC1 ERCC1 POLN POLN BRIP1 BRIP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPA3Replication protein A 14 kDa subunit. (121 aa)
FAAP100Fanconi anemia-associated protein of 100 kDa isoform b. (880 aa)
POLIDNA polymerase iota. (738 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (628 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
MUS81MUS81 structure-specific endonuclease subunit. (551 aa)
ATRIPATR-interacting protein isoform 1. (790 aa)
FANCBFA complementation group B. (863 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3105 aa)
POLHDNA polymerase eta. (709 aa)
UBE2TUbiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (198 aa)
WDR48WD repeat domain 48. (689 aa)
FANCIFA complementation group I. (1329 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1830 aa)
TELO2Telomere maintenance 2. (837 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (372 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (862 aa)
FANCEFanconi anemia group E protein. (535 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
RMI2Uncharacterized protein. (84 aa)
FANCD2FA complementation group D2. (1453 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (533 aa)
BRCA2BRCA2 DNA repair associated. (3409 aa)
EME1Essential meiotic structure-specific endonuclease 1. (584 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1830 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
FANCFFanconi anemia group F protein. (374 aa)
RMI1RecQ-mediated genome instability protein 1. (625 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (783 aa)
FANCMFA complementation group M. (2043 aa)
BLMBLM RecQ like helicase. (1415 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa)
RPA2RPA_C domain-containing protein. (355 aa)
LOC100385843Uncharacterized protein. (147 aa)
FAAP24Fanconi anemia-associated protein of 24 kDa. (215 aa)
APITD1Uncharacterized protein. (138 aa)
FANCLFA complementation group L. (380 aa)
POLKDNA polymerase kappa. (861 aa)
HES1Hes family bHLH transcription factor 1. (287 aa)
MLH1MutL homolog 1. (820 aa)
ENSCJAP00000071556Uncharacterized protein. (70 aa)
FANCGFanconi anemia group G protein. (622 aa)
PALB2Partner and localizer of BRCA2. (1182 aa)
ERCC1Uncharacterized protein. (356 aa)
POLNDNA polymerase nu. (863 aa)
BRIP1Uncharacterized protein. (213 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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