Your Input: | |||||
CCNE2 | G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa) | ||||
MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) | ||||
SMC1B | Structural maintenance of chromosomes protein. (1267 aa) | ||||
ANAPC5 | Anaphase-promoting complex subunit 5 isoform a. (755 aa) | ||||
CDC45 | Cell division cycle 45. (562 aa) | ||||
RBL2 | RB transcriptional corepressor like 2. (1153 aa) | ||||
CCND2 | G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa) | ||||
CCNE1 | G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa) | ||||
ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) | ||||
SMAD3 | Mothers against decapentaplegic homolog. (437 aa) | ||||
ANAPC10 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa) | ||||
CDC25A | M-phase inducer phosphatase 1 isoform a. (524 aa) | ||||
ANAPC13 | Anaphase-promoting complex subunit 13. (74 aa) | ||||
CCNA2 | Cyclin-A2; Belongs to the cyclin family. (432 aa) | ||||
MAD2L1 | Mitotic arrest deficient 2 like 1. (223 aa) | ||||
CDC14A | Cell division cycle 14A. (625 aa) | ||||
CDC20 | Cell division cycle 20. (499 aa) | ||||
RBX1 | E3 ubiquitin-protein ligase RBX1. (108 aa) | ||||
EP300 | E1A binding protein p300. (2426 aa) | ||||
RAD21 | Double-strand-break repair protein rad21 homolog. (631 aa) | ||||
SMC1A | Structural maintenance of chromosomes protein. (1233 aa) | ||||
YWHAQ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (245 aa) | ||||
CDC23 | Cell division cycle protein 23 homolog. (597 aa) | ||||
ZBTB17 | Zinc finger and BTB domain containing 17. (804 aa) | ||||
MCM2 | DNA helicase; Belongs to the MCM family. (904 aa) | ||||
RB1 | Retinoblastoma-associated protein. (927 aa) | ||||
ANAPC7 | Anaphase promoting complex subunit 7. (598 aa) | ||||
CUL1 | Cullin-1; Belongs to the cullin family. (776 aa) | ||||
ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) | ||||
TTK | TTK protein kinase. (857 aa) | ||||
WEE1 | Wee1-like protein kinase. (642 aa) | ||||
MCM3 | DNA helicase; Belongs to the MCM family. (851 aa) | ||||
CDC14B | Cell division cycle 14B. (498 aa) | ||||
MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa) | ||||
ORC5 | Origin recognition complex subunit 5 isoform 1. (435 aa) | ||||
MAD2L2 | Mitotic spindle assembly checkpoint protein MAD2B. (211 aa) | ||||
ANAPC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa) | ||||
CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa) | ||||
BUB1 | BUB1 mitotic checkpoint serine/threonine kinase. (1082 aa) | ||||
MCM4 | DNA helicase; Belongs to the MCM family. (955 aa) | ||||
WEE2 | Wee1-like protein kinase. (563 aa) | ||||
DBF4 | DBF4 zinc finger. (673 aa) | ||||
FZR1 | Fizzy and cell division cycle 20 related 1. (496 aa) | ||||
PKMYT1 | Protein kinase, membrane associated tyrosine/threonine 1; Belongs to the protein kinase superfamily. (476 aa) | ||||
YWHAZ | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (314 aa) | ||||
CCNB1 | G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (429 aa) | ||||
CDK7 | Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa) | ||||
ANAPC1 | Anaphase promoting complex subunit 1. (1945 aa) | ||||
GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha isoform 1. (165 aa) | ||||
CCNA1 | Cyclin A1; Belongs to the cyclin family. (421 aa) | ||||
SKP2 | S-phase kinase associated protein 2. (422 aa) | ||||
E2F1 | E2F transcription factor 1. (439 aa) | ||||
ESPL1 | Extra spindle pole bodies like 1, separase. (2121 aa) | ||||
SMC3 | Structural maintenance of chromosomes protein. (1217 aa) | ||||
CDC16 | Cell division cycle protein 16 homolog. (620 aa) | ||||
PTTG1 | PTTG1 regulator of sister chromatid separation, securin. (202 aa) | ||||
E2F3 | E2F transcription factor 3. (458 aa) | ||||
CREBBP | CREB-binding protein isoform a. (2449 aa) | ||||
TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) | ||||
PLK1 | Serine/threonine-protein kinase PLK. (597 aa) | ||||
BUB1B | Uncharacterized protein. (1044 aa) | ||||
CDC25B | Cell division cycle 25B. (588 aa) | ||||
CDC27 | Cell division cycle protein 27 homolog isoform 1. (830 aa) | ||||
ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (861 aa) | ||||
YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa) | ||||
CDKN1B | Cyclin-dependent kinase inhibitor 1B. (198 aa) | ||||
MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (720 aa) | ||||
BUB3 | Mitotic checkpoint protein BUB3 isoform a. (328 aa) | ||||
TFDP2 | Transcription factor. (447 aa) | ||||
CHEK2 | Uncharacterized protein. (543 aa) | ||||
ORC3 | Origin recognition complex subunit 3. (782 aa) | ||||
CDK4 | Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (302 aa) | ||||
STAG2 | Cohesin subunit SA-2 isoform a. (1268 aa) | ||||
ORC2 | Origin recognition complex subunit 2. (577 aa) | ||||
GSK3B | Glycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa) | ||||
MCM6 | DNA helicase; Belongs to the MCM family. (829 aa) | ||||
CCND1 | Cyclin D1; Belongs to the cyclin family. (531 aa) | ||||
YWHAG | 14-3-3 protein gamma; Belongs to the 14-3-3 family. (247 aa) | ||||
YWHAH | Uncharacterized protein. (70 aa) | ||||
YWHAB | 14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (246 aa) | ||||
SMAD4 | Mothers against decapentaplegic homolog. (552 aa) | ||||
CCNH | Cyclin H; Belongs to the cyclin family. (325 aa) | ||||
CCND3 | G1/S-specific cyclin-D3 isoform 2; Belongs to the cyclin family. (292 aa) | ||||
CDC26 | Anaphase-promoting complex subunit CDC26. (85 aa) | ||||
LOC100387754 | Transcription factor. (439 aa) | ||||
ORC6 | Origin recognition complex subunit 6. (251 aa) | ||||
CDK1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa) | ||||
CDKN1A | Cyclin-dependent kinase inhibitor 1. (158 aa) | ||||
CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) | ||||
MAD1L1 | Mitotic arrest deficient 1 like 1. (718 aa) | ||||
ANAPC11 | Anaphase-promoting complex subunit 11 isoform 2. (84 aa) | ||||
GADD45B | Growth arrest and DNA damage inducible beta. (201 aa) | ||||
STAG1 | Stromal antigen 1. (1272 aa) | ||||
SFN | Stratifin; Belongs to the 14-3-3 family. (248 aa) | ||||
CDC7 | Cell division cycle 7-related protein kinase. (575 aa) | ||||
ABL1 | Tyrosine-protein kinase. (1149 aa) | ||||
TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (396 aa) | ||||
PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) | ||||
CDKN2C | Cyclin-dependent kinase 4 inhibitor C. (168 aa) | ||||
ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (441 aa) | ||||
TGFB3 | Transforming growth factor beta 3. (428 aa) | ||||
CDKN2D | Cyclin-dependent kinase 4 inhibitor D. (166 aa) | ||||
PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4134 aa) | ||||
GADD45G | Growth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa) | ||||
SKP1 | S-phase kinase-associated protein 1 isoform b; Belongs to the SKP1 family. (163 aa) | ||||
HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (491 aa) | ||||
CCNB3 | Cyclin B3; Belongs to the cyclin family. (1416 aa) | ||||
CDKN1C | Uncharacterized protein. (475 aa) | ||||
HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (540 aa) |