STRINGSTRING
CCNE2 CCNE2 MCM5 MCM5 SMC1B SMC1B ANAPC5 ANAPC5 CDC45 CDC45 RBL2 RBL2 CCND2 CCND2 CCNE1 CCNE1 ATR ATR SMAD3 SMAD3 ANAPC10 ANAPC10 CDC25A CDC25A ANAPC13 ANAPC13 CCNA2 CCNA2 MAD2L1 MAD2L1 CDC14A CDC14A CDC20 CDC20 RBX1 RBX1 EP300 EP300 RAD21 RAD21 SMC1A SMC1A YWHAQ YWHAQ CDC23 CDC23 ZBTB17 ZBTB17 MCM2 MCM2 RB1 RB1 ANAPC7 ANAPC7 CUL1 CUL1 ATM ATM TTK TTK WEE1 WEE1 MCM3 MCM3 CDC14B CDC14B MYC MYC ORC5 ORC5 MAD2L2 MAD2L2 ANAPC4 ANAPC4 CDC6 CDC6 BUB1 BUB1 MCM4 MCM4 WEE2 WEE2 DBF4 DBF4 FZR1 FZR1 PKMYT1 PKMYT1 YWHAZ YWHAZ CCNB1 CCNB1 CDK7 CDK7 ANAPC1 ANAPC1 GADD45A GADD45A CCNA1 CCNA1 SKP2 SKP2 E2F1 E2F1 ESPL1 ESPL1 SMC3 SMC3 CDC16 CDC16 PTTG1 PTTG1 E2F3 E2F3 CREBBP CREBBP TGFB1 TGFB1 PLK1 PLK1 BUB1B BUB1B CDC25B CDC25B CDC27 CDC27 ORC1 ORC1 YWHAE YWHAE CDKN1B CDKN1B MCM7 MCM7 BUB3 BUB3 TFDP2 TFDP2 CHEK2 CHEK2 ORC3 ORC3 CDK4 CDK4 STAG2 STAG2 ORC2 ORC2 GSK3B GSK3B MCM6 MCM6 CCND1 CCND1 YWHAG YWHAG YWHAH YWHAH YWHAB YWHAB SMAD4 SMAD4 CCNH CCNH CCND3 CCND3 CDC26 CDC26 LOC100387754 LOC100387754 ORC6 ORC6 CDK1 CDK1 CDKN1A CDKN1A CDK6 CDK6 MAD1L1 MAD1L1 ANAPC11 ANAPC11 GADD45B GADD45B STAG1 STAG1 SFN SFN CDC7 CDC7 ABL1 ABL1 TP53 TP53 PCNA PCNA CDKN2C CDKN2C ORC4 ORC4 TGFB3 TGFB3 CDKN2D CDKN2D PRKDC PRKDC GADD45G GADD45G SKP1 SKP1 HDAC2 HDAC2 CCNB3 CCNB3 CDKN1C CDKN1C HDAC1 HDAC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
SMC1BStructural maintenance of chromosomes protein. (1267 aa)
ANAPC5Anaphase-promoting complex subunit 5 isoform a. (755 aa)
CDC45Cell division cycle 45. (562 aa)
RBL2RB transcriptional corepressor like 2. (1153 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
SMAD3Mothers against decapentaplegic homolog. (437 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
CDC25AM-phase inducer phosphatase 1 isoform a. (524 aa)
ANAPC13Anaphase-promoting complex subunit 13. (74 aa)
CCNA2Cyclin-A2; Belongs to the cyclin family. (432 aa)
MAD2L1Mitotic arrest deficient 2 like 1. (223 aa)
CDC14ACell division cycle 14A. (625 aa)
CDC20Cell division cycle 20. (499 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (108 aa)
EP300E1A binding protein p300. (2426 aa)
RAD21Double-strand-break repair protein rad21 homolog. (631 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (245 aa)
CDC23Cell division cycle protein 23 homolog. (597 aa)
ZBTB17Zinc finger and BTB domain containing 17. (804 aa)
MCM2DNA helicase; Belongs to the MCM family. (904 aa)
RB1Retinoblastoma-associated protein. (927 aa)
ANAPC7Anaphase promoting complex subunit 7. (598 aa)
CUL1Cullin-1; Belongs to the cullin family. (776 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
TTKTTK protein kinase. (857 aa)
WEE1Wee1-like protein kinase. (642 aa)
MCM3DNA helicase; Belongs to the MCM family. (851 aa)
CDC14BCell division cycle 14B. (498 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa)
ORC5Origin recognition complex subunit 5 isoform 1. (435 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
BUB1BUB1 mitotic checkpoint serine/threonine kinase. (1082 aa)
MCM4DNA helicase; Belongs to the MCM family. (955 aa)
WEE2Wee1-like protein kinase. (563 aa)
DBF4DBF4 zinc finger. (673 aa)
FZR1Fizzy and cell division cycle 20 related 1. (496 aa)
PKMYT1Protein kinase, membrane associated tyrosine/threonine 1; Belongs to the protein kinase superfamily. (476 aa)
YWHAZ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (314 aa)
CCNB1G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (429 aa)
CDK7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
ANAPC1Anaphase promoting complex subunit 1. (1945 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform 1. (165 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
SKP2S-phase kinase associated protein 2. (422 aa)
E2F1E2F transcription factor 1. (439 aa)
ESPL1Extra spindle pole bodies like 1, separase. (2121 aa)
SMC3Structural maintenance of chromosomes protein. (1217 aa)
CDC16Cell division cycle protein 16 homolog. (620 aa)
PTTG1PTTG1 regulator of sister chromatid separation, securin. (202 aa)
E2F3E2F transcription factor 3. (458 aa)
CREBBPCREB-binding protein isoform a. (2449 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PLK1Serine/threonine-protein kinase PLK. (597 aa)
BUB1BUncharacterized protein. (1044 aa)
CDC25BCell division cycle 25B. (588 aa)
CDC27Cell division cycle protein 27 homolog isoform 1. (830 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (861 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (720 aa)
BUB3Mitotic checkpoint protein BUB3 isoform a. (328 aa)
TFDP2Transcription factor. (447 aa)
CHEK2Uncharacterized protein. (543 aa)
ORC3Origin recognition complex subunit 3. (782 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (302 aa)
STAG2Cohesin subunit SA-2 isoform a. (1268 aa)
ORC2Origin recognition complex subunit 2. (577 aa)
GSK3BGlycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa)
MCM6DNA helicase; Belongs to the MCM family. (829 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (531 aa)
YWHAG14-3-3 protein gamma; Belongs to the 14-3-3 family. (247 aa)
YWHAHUncharacterized protein. (70 aa)
YWHAB14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (246 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CCNHCyclin H; Belongs to the cyclin family. (325 aa)
CCND3G1/S-specific cyclin-D3 isoform 2; Belongs to the cyclin family. (292 aa)
CDC26Anaphase-promoting complex subunit CDC26. (85 aa)
LOC100387754Transcription factor. (439 aa)
ORC6Origin recognition complex subunit 6. (251 aa)
CDK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (158 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (718 aa)
ANAPC11Anaphase-promoting complex subunit 11 isoform 2. (84 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (201 aa)
STAG1Stromal antigen 1. (1272 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
CDC7Cell division cycle 7-related protein kinase. (575 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (396 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (441 aa)
TGFB3Transforming growth factor beta 3. (428 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D. (166 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4134 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
SKP1S-phase kinase-associated protein 1 isoform b; Belongs to the SKP1 family. (163 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (491 aa)
CCNB3Cyclin B3; Belongs to the cyclin family. (1416 aa)
CDKN1CUncharacterized protein. (475 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (540 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
Server load: low (20%) [HD]