STRINGSTRING
PRKCA PRKCA VWF VWF PPP1CA PPP1CA ERBB2 ERBB2 ITGB8 ITGB8 VCL VCL MYL9 MYL9 ITGA1 ITGA1 ITGA2 ITGA2 CCND2 CCND2 SHC4 SHC4 CRK CRK COL6A3 COL6A3 ITGA11 ITGA11 RASGRF1 RASGRF1 LOC100409006 LOC100409006 COL9A2 COL9A2 COL6A5 COL6A5 HGF HGF LAMA2 LAMA2 LAMB2 LAMB2 BIRC2 BIRC2 COL9A1 COL9A1 EGF EGF COL1A1 COL1A1 TLN2 TLN2 LAMA4 LAMA4 FYN FYN PDGFA PDGFA LAMC2 LAMC2 MET MET CAV2 CAV2 ARHGAP5 ARHGAP5 IBSP IBSP SPP1 SPP1 IGF1R IGF1R ITGB5 ITGB5 ITGA3 ITGA3 PIP5K1A PIP5K1A MAP2K1 MAP2K1 ITGA6 ITGA6 COL4A5 COL4A5 MYLK MYLK COL4A6 COL4A6 ITGA7 ITGA7 CAPN2 CAPN2 LAMC3 LAMC3 VAV3 VAV3 THBS3 THBS3 TNR TNR TNN TNN ITGA8 ITGA8 SHC1 SHC1 ZYX ZYX PDGFD PDGFD ITGA2B ITGA2B MAPK9 MAPK9 ARHGAP35 ARHGAP35 FN1 FN1 ELK1 ELK1 VTN VTN RELN RELN MYL12A MYL12A COL4A3 COL4A3 PIK3CA PIK3CA RAP1A RAP1A MAPK8 MAPK8 RHOA RHOA COL1A2 COL1A2 ITGB1 ITGB1 ACTN4 ACTN4 PAK4 PAK4 PIK3R2 PIK3R2 ITGB4 ITGB4 BCAR1 BCAR1 AKT2 AKT2 COL4A1 COL4A1 PDPK1 PDPK1 PARVB PARVB SOS1 SOS1 COL2A1 COL2A1 LAMA1 LAMA1 PIK3R1 PIK3R1 MYLPF MYLPF MYL10 MYL10 LOC100410496 LOC100410496 LAMB1 LAMB1 RAF1 RAF1 AKT3 AKT3 CTNNB1 CTNNB1 FLNC FLNC FLNA FLNA BAD BAD VEGFB VEGFB RAC3 RAC3 KDR KDR ITGB7 ITGB7 PDGFRA PDGFRA CHAD CHAD ITGA5 ITGA5 PPP1R12A PPP1R12A ITGB3 ITGB3 TNC TNC ROCK1 ROCK1 ROCK2 ROCK2 XIAP XIAP LAMA3 LAMA3 MYLK2 MYLK2 PIK3R3 PIK3R3 PAK5 PAK5 PPP1R12C PPP1R12C ITGAV ITGAV VAV1 VAV1 COL6A2 COL6A2 ILK ILK PAK1 PAK1 MAPK1 MAPK1 PAK2 PAK2 RAP1B RAP1B SOS2 SOS2 LAMB3 LAMB3 PRKCG PRKCG GSK3B GSK3B PIK3CB PIK3CB VEGFD VEGFD COL6A6 COL6A6 PPP1CC PPP1CC VEGFC VEGFC CCND1 CCND1 LOC100407817 LOC100407817 PTEN PTEN PPP1CB PPP1CB PARVG PARVG PDGFC PDGFC MYL2 MYL2 IGF1 IGF1 CCND3 CCND3 MAPK3 MAPK3 SHC3 SHC3 PARVA PARVA HRAS HRAS CDC42 CDC42 FLT1 FLT1 THBS2 THBS2 PDGFB PDGFB JUN JUN MAPK10 MAPK10 FLNB FLNB PIP5K1B PIP5K1B ITGB6 ITGB6 GRB2 GRB2 MYL12B MYL12B PRKCB PRKCB ITGA4 ITGA4 PAK6 PAK6 THBS4 THBS4 PTK2 PTK2 THBS1 THBS1 TLN1 TLN1 AKT1 AKT1 LAMB4 LAMB4 CRKL CRKL LAMC1 LAMC1 ENSCJAP00000072561 ENSCJAP00000072561 PDGFRB PDGFRB MYL5 MYL5 SRC SRC VAV2 VAV2 EGFR EGFR FLT4 FLT4 CAV1 CAV1 CAV3 CAV3 ENSCJAP00000077601 ENSCJAP00000077601
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
VWFVon Willebrand factor. (2814 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (770 aa)
VCLVinculin. (1128 aa)
MYL9Myosin regulatory light polypeptide 9 isoform a. (172 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1182 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
SHC4SHC adaptor protein 4. (627 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
COL6A3Collagen type VI alpha 3 chain. (3176 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1188 aa)
RASGRF1Ras-specific guanine nucleotide-releasing factor 1 isoform 1. (1262 aa)
LOC100409006Uncharacterized protein. (375 aa)
COL9A2Collagen type IX alpha 2 chain. (689 aa)
COL6A5Collagen type VI alpha 5 chain. (2610 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (813 aa)
LAMA2Uncharacterized protein. (3122 aa)
LAMB2Laminin subunit beta 2. (1798 aa)
BIRC2Baculoviral IAP repeat-containing protein 2 isoform 1. (617 aa)
COL9A1Collagen type IX alpha 1 chain. (921 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
COL1A1Collagen alpha-1(I) chain preproprotein. (1464 aa)
TLN2Talin-2. (2542 aa)
LAMA4Laminin subunit alpha-4 isoform 1. (1823 aa)
FYNTyrosine-protein kinase. (537 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (443 aa)
LAMC2Laminin subunit gamma 2. (1193 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1353 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
ARHGAP5Rho GTPase-activating protein 5 isoform b. (1501 aa)
IBSPIntegrin binding sialoprotein. (317 aa)
SPP1Secreted phosphoprotein 1. (321 aa)
IGF1RTyrosine-protein kinase receptor. (1366 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1055 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 2. (550 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
COL4A5Collagen alpha-5(IV) chain isoform 1. (1691 aa)
MYLKMyosin light chain kinase. (1936 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (672 aa)
LAMC3Laminin subunit gamma 3. (1577 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
THBS3Thrombospondin-3 isoform 1. (956 aa)
TNRTenascin-R. (1358 aa)
TNNTenascin N. (1299 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
SHC1SHC-transforming protein 1 isoform 3. (577 aa)
ZYXZyxin. (570 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (456 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1037 aa)
MAPK9Mitogen-activated protein kinase. (441 aa)
ARHGAP35Rho GTPase activating protein 35. (1499 aa)
FN1Fibronectin isoform 1 preproprotein. (2478 aa)
ELK1ETS transcription factor ELK1. (479 aa)
VTNSMB domain-containing protein. (458 aa)
RELNReelin. (3460 aa)
MYL12AUncharacterized protein. (205 aa)
COL4A3Collagen type IV alpha 3 chain. (1661 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
MAPK8Mitogen-activated protein kinase. (450 aa)
RHOATransforming protein RhoA. (193 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (1087 aa)
ACTN4Actinin alpha 4. (911 aa)
PAK4Non-specific serine/threonine protein kinase. (593 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
ITGB4Integrin beta. (1820 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (892 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
COL4A1Collagen alpha-1(IV) chain preproprotein. (1669 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform 1. (556 aa)
PARVBParvin beta. (389 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
COL2A1Collagen type II alpha 1 chain. (1128 aa)
LAMA1Laminin subunit alpha 1. (3080 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1. (724 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (181 aa)
MYL10Myosin light chain 10. (224 aa)
LOC100410496Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
LAMB1Laminin subunit beta 1. (1788 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CTNNB1Catenin beta 1. (774 aa)
FLNCFilamin C. (2692 aa)
FLNAFilamin A. (2649 aa)
BADBcl2 antagonist of cell death. (167 aa)
VEGFBVascular endothelial growth factor B isoform VEGFB-186; Belongs to the PDGF/VEGF growth factor family. (207 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (192 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (798 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
CHADChondroadherin. (359 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1049 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1030 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
TNCTenascin C. (2201 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
XIAPBaculoviral IAP repeat-containing 4 (Predicted). (497 aa)
LAMA3Laminin subunit alpha 3. (3339 aa)
MYLK2Myosin light chain kinase 2. (596 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (781 aa)
ITGAVIntegrin alpha-V isoform 1; Belongs to the integrin alpha chain family. (1047 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
COL6A2Uncharacterized protein. (424 aa)
ILKIntegrin linked kinase. (483 aa)
PAK1Non-specific serine/threonine protein kinase. (554 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
RAP1BRas-related protein Rap-1b isoform 1. (184 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (698 aa)
GSK3BGlycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform 1; Belongs to the PI3/PI4-kinase family. (1070 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (356 aa)
COL6A6Collagen type VI alpha 6 chain. (2288 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (402 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (531 aa)
LOC100407817WH1 domain-containing protein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PARVGGamma-parvin isoform 1. (330 aa)
PDGFCPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (344 aa)
MYL2Myosin light chain 2. (165 aa)
IGF1Insulin like growth factor 1. (197 aa)
CCND3G1/S-specific cyclin-D3 isoform 2; Belongs to the cyclin family. (292 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa)
SHC3SHC adaptor protein 3. (625 aa)
PARVAParvin alpha. (492 aa)
HRASHRas proto-oncogene, GTPase. (209 aa)
CDC42Cell division control protein 42 homolog isoform 1. (191 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
THBS2Thrombospondin 2. (1255 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
MAPK10Mitogen-activated protein kinase. (552 aa)
FLNBFilamin-B isoform 1. (2633 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (555 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
MYL12BMyosin regulatory light chain 12B. (172 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
PAK6Non-specific serine/threonine protein kinase. (687 aa)
THBS4Uncharacterized protein. (1022 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
THBS1Thrombospondin 1. (1178 aa)
TLN1Talin 1. (2589 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (459 aa)
LAMB4Laminin subunit beta 4. (1771 aa)
CRKLCrk-like protein. (303 aa)
LAMC1Laminin subunit gamma-1. (1608 aa)
ENSCJAP00000072561Uncharacterized protein. (2353 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1108 aa)
MYL5EF-hand domain-containing protein. (173 aa)
SRCTyrosine-protein kinase. (553 aa)
VAV2Vav guanine nucleotide exchange factor 2. (988 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1366 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
ENSCJAP00000077601Uncharacterized protein. (168 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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