STRINGSTRING
NCK1 NCK1 FYN FYN NFKBIA NFKBIA PTPN6 PTPN6 MAP2K1 MAP2K1 IKBKB IKBKB NCK2 NCK2 VAV3 VAV3 MAPK9 MAPK9 ZAP70 ZAP70 LCP2 LCP2 NRAS NRAS MAP3K14 MAP3K14 CSF2 CSF2 IL5 IL5 IL4 IL4 CD3D CD3D MAP3K8 MAP3K8 PIK3CA PIK3CA MAPK8 MAPK8 RHOA RHOA DLG1 DLG1 NFKBIB NFKBIB PAK4 PAK4 PIK3R2 PIK3R2 AKT2 AKT2 PDPK1 PDPK1 SOS1 SOS1 NFKB1 NFKB1 NFATC3 NFATC3 MAPK13 MAPK13 PIK3R1 PIK3R1 RAF1 RAF1 IKBKG IKBKG AKT3 AKT3 PLCG1 PLCG1 IL10 IL10 ITK ITK TEC TEC CD8B CD8B CD8A CD8A PDCD1 PDCD1 PPP3CC PPP3CC PRKCQ PRKCQ RASGRP1 RASGRP1 PIK3R3 PIK3R3 PAK5 PAK5 CD247 CD247 VAV1 VAV1 CD4 CD4 PAK1 PAK1 PTPRC PTPRC MAPK1 MAPK1 PAK2 PAK2 CDK4 CDK4 SOS2 SOS2 GSK3B GSK3B PIK3CB PIK3CB TNF TNF NFATC2 NFATC2 CBLB CBLB CD40LG CD40LG IFNG IFNG CD3E CD3E MAPK3 MAPK3 MAP3K7 MAP3K7 PPP3CB PPP3CB NFATC1 NFATC1 HRAS HRAS CDC42 CDC42 CTLA4 CTLA4 JUN JUN IL2 IL2 MAPK10 MAPK10 PPP3R1 PPP3R1 CD3G CD3G MAPK14 MAPK14 MALT1 MALT1 GRB2 GRB2 CD28 CD28 PPP3CA PPP3CA ICOS ICOS NFKBIE NFKBIE PAK6 PAK6 AKT1 AKT1 MAPK12 MAPK12 FOS FOS TRBV4-1 TRBV4-1 VAV2 VAV2 RELA RELA BCL10 BCL10 TRBV5-3 TRBV5-3 TRAV8-6S1 TRAV8-6S1 CARD11 CARD11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCK1Cytoplasmic protein. (377 aa)
FYNTyrosine-protein kinase. (537 aa)
NFKBIANF-kappa-B inhibitor alpha. (310 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (622 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa)
NCK2Cytoplasmic protein. (380 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
MAPK9Mitogen-activated protein kinase. (441 aa)
ZAP70Zeta chain of T cell receptor associated protein kinase 70. (648 aa)
LCP2Lymphocyte cytosolic protein 2. (532 aa)
NRASGTPase NRas. (189 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (951 aa)
CSF2Colony stimulating factor 2 (Predicted). (144 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (151 aa)
CD3DIg_4 domain-containing protein. (283 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK8Mitogen-activated protein kinase. (450 aa)
RHOATransforming protein RhoA. (193 aa)
DLG1Uncharacterized protein; Belongs to the MAGUK family. (938 aa)
NFKBIBNF-kappa-B inhibitor beta isoform 1. (356 aa)
PAK4Non-specific serine/threonine protein kinase. (593 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform 1. (556 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
NFKB1Nuclear factor kappa B subunit 1. (998 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform 1. (1075 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1. (724 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (452 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
ITKTyrosine-protein kinase. (620 aa)
TECTyrosine-protein kinase. (631 aa)
CD8BIg-like domain-containing protein. (220 aa)
CD8ACD8a molecule. (236 aa)
PDCD1Programmed cell death 1. (288 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (710 aa)
RASGRP1RAS guanyl releasing protein 1. (826 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
CD247CD247 molecule. (166 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
CD4Ig-like domain-containing protein. (457 aa)
PAK1Non-specific serine/threonine protein kinase. (554 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1252 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (302 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
GSK3BGlycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform 1; Belongs to the PI3/PI4-kinase family. (1070 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (232 aa)
NFATC2Nuclear factor of activated T cells 2. (923 aa)
CBLBCbl proto-oncogene B. (992 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
CD3ECD3e molecule. (232 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
NFATC1Nuclear factor of activated T cells 1. (1218 aa)
HRASHRas proto-oncogene, GTPase. (209 aa)
CDC42Cell division control protein 42 homolog isoform 1. (191 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
MAPK10Mitogen-activated protein kinase. (552 aa)
PPP3R1Uncharacterized protein. (189 aa)
CD3GCD3g molecule. (210 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MALT1MALT1 paracaspase. (824 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
CD28IGv domain-containing protein. (234 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ICOSInducible T cell costimulator. (211 aa)
NFKBIENFKB inhibitor epsilon. (408 aa)
PAK6Non-specific serine/threonine protein kinase. (687 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (459 aa)
MAPK12Mitogen-activated protein kinase. (466 aa)
FOSProto-oncogene c-Fos. (380 aa)
TRBV4-1T cell receptor beta variable 4-1. (162 aa)
VAV2Vav guanine nucleotide exchange factor 2. (988 aa)
RELARELA proto-oncogene, NF-kB subunit. (571 aa)
BCL10B-cell lymphoma/leukemia 10. (233 aa)
TRBV5-3Ig-like domain-containing protein. (193 aa)
TRAV8-6S1Ig-like domain-containing protein. (131 aa)
CARD11Caspase recruitment domain-containing protein 11. (1154 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.