STRINGSTRING
PPARA PPARA ADIPOR2 ADIPOR2 NDUFV1 NDUFV1 COX6A2 COX6A2 LOC100388954 LOC100388954 LOC100395443 LOC100395443 MAP3K11 MAP3K11 ATF4 ATF4 NDUFA9 NDUFA9 UQCRC1 UQCRC1 BCL2L11 BCL2L11 NDUFB3 NDUFB3 NDUFB7 NDUFB7 CYP2E1 CYP2E1 MLX MLX NDUFS2 NDUFS2 NDUFA13 NDUFA13 CASP3 CASP3 ADIPOR1 ADIPOR1 PRKAA1 PRKAA1 IKBKB IKBKB SDHB SDHB MAP3K5 MAP3K5 NDUFB4 NDUFB4 LOC100389097 LOC100389097 FASLG FASLG LOC100390127 LOC100390127 MAPK9 MAPK9 NDUFA7 NDUFA7 SDHD SDHD COX7C COX7C NDUFB5 NDUFB5 UQCRQ UQCRQ PIK3CA PIK3CA NDUFB2 NDUFB2 H9KX01_CALJA H9KX01_CALJA MAPK8 MAPK8 PIK3R2 PIK3R2 AKT2 AKT2 EIF2S1 EIF2S1 NFKB1 NFKB1 NDUFS8 NDUFS8 NDUFV3 NDUFV3 PRKAA2 PRKAA2 PIK3R1 PIK3R1 IL1B IL1B IL1A IL1A LEPR LEPR AKT3 AKT3 BID BID NDUFB8 NDUFB8 LEP LEP ITCH ITCH INS INS NDUFA3 NDUFA3 COX7B2 COX7B2 XBP1 XBP1 TGFB1 TGFB1 NDUFS3 NDUFS3 MLXIP MLXIP PRKAG2 PRKAG2 NDUFAB1 NDUFAB1 PRKAG1 PRKAG1 PIK3R3 PIK3R3 LOC100406481 LOC100406481 CYC1 CYC1 SOCS3 SOCS3 LOC100407930 LOC100407930 LOC100895863 LOC100895863 NDUFB9 NDUFB9 COX7A1 COX7A1 SREBF1 SREBF1 DDIT3 DDIT3 UQCRB UQCRB GSK3A GSK3A IL6 IL6 PKLR PKLR PRKAB1 PRKAB1 EIF2AK3 EIF2AK3 GSK3B GSK3B PIK3CB PIK3CB TNF TNF RXRA RXRA IL6R IL6R INSR INSR LOC108591148 LOC108591148 COX8A COX8A LOC100413276 LOC100413276 NDUFC1 NDUFC1 NDUFB1 NDUFB1 COX4I1 COX4I1 ENSCJAP00000056951 ENSCJAP00000056951 COX5A COX5A NDUFA10 NDUFA10 NDUFV2 NDUFV2 NDUFS7 NDUFS7 NDUFA2 NDUFA2 NDUFB10 NDUFB10 NDUFA5 NDUFA5 LOC100406761 LOC100406761 LOC103793463 LOC103793463 ENSCJAP00000059748 ENSCJAP00000059748 NDUFA1 NDUFA1 LOC108593294 LOC108593294 COX4I2 COX4I2 LOC100401718 LOC100401718 NDUFS5 NDUFS5 BAX BAX NDUFA4 NDUFA4 NDUFA6 NDUFA6 CDC42 CDC42 LOC108593648 LOC108593648 JUN JUN MAPK10 MAPK10 SDHA SDHA LOC100407794 LOC100407794 COX8C COX8C NDUFA4L2 NDUFA4L2 LOC108587827 LOC108587827 NDUFS1 NDUFS1 NDUFS6 NDUFS6 NDUFA8 NDUFA8 CASP7 CASP7 NDUFS4 NDUFS4 NDUFA12 NDUFA12 AKT1 AKT1 IRS1 IRS1 ENSCJAP00000072771 ENSCJAP00000072771 LOC100401813 LOC100401813 PRKAG3 PRKAG3 FOS FOS COX7B COX7B TNFRSF1A TNFRSF1A COX6B2 COX6B2 CXCL8 CXCL8 ENSCJAP00000074289 ENSCJAP00000074289 RELA RELA ADIPOQ ADIPOQ TRAF2 TRAF2 ENSCJAP00000075971 ENSCJAP00000075971 FAS FAS NDUFC2 NDUFC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPARAPeroxisome proliferator-activated receptor alpha. (468 aa)
ADIPOR2Adiponectin receptor protein 2. (386 aa)
NDUFV1NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (464 aa)
COX6A2Cytochrome c oxidase subunit 6A, mitochondrial. (136 aa)
LOC100388954Cytochrome c oxidase subunit 6A, mitochondrial. (108 aa)
LOC100395443Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (274 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (847 aa)
ATF4Activating transcription factor 4. (351 aa)
NDUFA9NADH:ubiquinone oxidoreductase subunit A9. (377 aa)
UQCRC1Ubiquinol-cytochrome c reductase core protein 1. (491 aa)
BCL2L11BCL2 like 11. (249 aa)
NDUFB3NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3. (98 aa)
NDUFB7NADH:ubiquinone oxidoreductase subunit B7. (138 aa)
CYP2E1Uncharacterized protein; Belongs to the cytochrome P450 family. (528 aa)
MLXMAX dimerization protein MLX. (298 aa)
NDUFS2NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform 1; Belongs to the complex I 49 kDa subunit family. (463 aa)
NDUFA13Uncharacterized protein. (151 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (284 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (280 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1481 aa)
NDUFB4NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 isoform 1. (128 aa)
LOC100389097Cytochrome b-c1 complex subunit 2, mitochondrial. (453 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
LOC100390127Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (86 aa)
MAPK9Mitogen-activated protein kinase. (441 aa)
NDUFA7NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7. (113 aa)
SDHDSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
COX7CCytochrome c oxidase subunit 7C. (63 aa)
NDUFB5Uncharacterized protein. (189 aa)
UQCRQUbiquinol-cytochrome c reductase complex III subunit VII. (82 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NDUFB2NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial. (105 aa)
H9KX01_CALJAUncharacterized protein. (114 aa)
MAPK8Mitogen-activated protein kinase. (450 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
NFKB1Nuclear factor kappa B subunit 1. (998 aa)
NDUFS8Uncharacterized protein. (210 aa)
NDUFV3NADH:ubiquinone oxidoreductase subunit V3. (472 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1. (724 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (272 aa)
LEPRLeptin receptor. (1165 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (192 aa)
NDUFB8NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (186 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
ITCHE3 ubiquitin-protein ligase. (864 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
NDUFA3Uncharacterized protein. (84 aa)
COX7B2Cytochrome c oxidase subunit 7B2. (81 aa)
XBP1BZIP domain-containing protein. (371 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
NDUFS3NADH:ubiquinone oxidoreductase core subunit S3; Belongs to the complex I 30 kDa subunit family. (262 aa)
MLXIPMLX-interacting protein. (919 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa)
NDUFAB1Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (156 aa)
PRKAG1Uncharacterized protein. (340 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
LOC100406481Cytochrome b-c1 complex subunit 6; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. Belongs to the UQCRH/QCR6 family. (91 aa)
CYC1Cytochrome c1, heme protein, mitochondrial. (325 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
LOC100407930Uncharacterized protein. (116 aa)
LOC100895863Cytochrome b-c1 complex subunit 10. (56 aa)
NDUFB9NADH:ubiquinone oxidoreductase subunit B9; Belongs to the complex I LYR family. (185 aa)
COX7A1Uncharacterized protein. (80 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1178 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
UQCRBUbiquinol-cytochrome c reductase binding protein. (161 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
IL6Interleukin 6. (212 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3. (1117 aa)
GSK3BGlycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform 1; Belongs to the PI3/PI4-kinase family. (1070 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (232 aa)
RXRARetinoid X receptor alpha. (492 aa)
IL6RUncharacterized protein. (468 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
LOC108591148Uncharacterized protein. (82 aa)
COX8ACytochrome c oxidase subunit 8A. (69 aa)
LOC100413276Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
NDUFC1NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial. (76 aa)
NDUFB1Uncharacterized protein. (59 aa)
COX4I1Cytochrome c oxidase subunit 4I1. (169 aa)
ENSCJAP00000056951Uncharacterized protein. (82 aa)
COX5AUncharacterized protein. (150 aa)
NDUFA10NADH:ubiquinone oxidoreductase subunit A10. (272 aa)
NDUFV2NADH:ubiquinone oxidoreductase core subunit V2. (249 aa)
NDUFS7Oxidored_q6 domain-containing protein; Belongs to the complex I 20 kDa subunit family. (142 aa)
NDUFA2NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (99 aa)
NDUFB10NADH:ubiquinone oxidoreductase subunit B10. (178 aa)
NDUFA5NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5. (116 aa)
LOC100406761Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC103793463Uncharacterized protein. (151 aa)
ENSCJAP00000059748DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (195 aa)
NDUFA1NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1. (70 aa)
LOC108593294Uncharacterized protein. (70 aa)
COX4I2Cytochrome c oxidase subunit 4 isoform 2, mitochondrial. (171 aa)
LOC100401718Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
NDUFS5NADH dehydrogenase [ubiquinone] iron-sulfur protein 5. (106 aa)
BAXBCL2 associated X, apoptosis regulator. (193 aa)
NDUFA4NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4. (82 aa)
NDUFA6NADH:ubiquinone oxidoreductase subunit A6; Belongs to the complex I LYR family. (154 aa)
CDC42Cell division control protein 42 homolog isoform 1. (191 aa)
LOC108593648Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
MAPK10Mitogen-activated protein kinase. (552 aa)
SDHASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (664 aa)
LOC100407794Uncharacterized protein. (63 aa)
COX8CCytochrome c oxidase subunit 8C. (72 aa)
NDUFA4L2NDUFA4 mitochondrial complex associated like 2. (87 aa)
LOC108587827Uncharacterized protein. (63 aa)
NDUFS1NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family. (741 aa)
NDUFS6zf-CHCC domain-containing protein. (252 aa)
NDUFA8NADH:ubiquinone oxidoreductase subunit A8. (244 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (303 aa)
NDUFS4NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial. (175 aa)
NDUFA12NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (145 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (459 aa)
IRS1Insulin receptor substrate 1. (1254 aa)
ENSCJAP00000072771Uncharacterized protein. (207 aa)
LOC100401813Uncharacterized protein. (204 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (571 aa)
FOSProto-oncogene c-Fos. (380 aa)
COX7BCytochrome c oxidase subunit 7B. (84 aa)
TNFRSF1ATNF receptor superfamily member 1A. (508 aa)
COX6B2Uncharacterized protein. (94 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
ENSCJAP00000074289Uncharacterized protein. (128 aa)
RELARELA proto-oncogene, NF-kB subunit. (571 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (299 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
ENSCJAP00000075971Uncharacterized protein. (120 aa)
FASFas cell surface death receptor. (454 aa)
NDUFC2NADH dehydrogenase [ubiquinone] 1 subunit C2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (126 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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