(44 nodes) Homologous recombination network (Vavraia culicis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VCUG_02715	Uncharacterized protein. (92 aa)
	VCUG_00172	Uncharacterized protein. (92 aa)
	VCUG_00230	Recombination protein rad52. (261 aa)
	VCUG_00424	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (849 aa)
	VCUG_00409	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (612 aa)
	VCUG_00905	DNA polymerase. (1168 aa)
	VCUG_00978	Helicase ATP-binding domain-containing protein. (855 aa)
	VCUG_01179	Uncharacterized protein. (96 aa)
	VCUG_00973	Uncharacterized protein. (85 aa)
	VCUG_01109	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (343 aa)
	VCUG_01218	Uncharacterized protein. (92 aa)
	VCUG_01272	Uncharacterized protein. (71 aa)
	VCUG_01677	BRCA-2_OB1 domain-containing protein. (1116 aa)
	VCUG_01731	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (574 aa)
	VCUG_01863	Uncharacterized protein. (386 aa)
	VCUG_02479	Uncharacterized protein. (71 aa)
	VCUG_02665	Uncharacterized protein. (92 aa)
	VCUG_02459	Uncharacterized protein. (91 aa)
	VCUG_02724	Uncharacterized protein. (95 aa)
	VCUG_02698	Uncharacterized protein. (87 aa)
	VCUG_02458	Uncharacterized protein. (91 aa)
	VCUG_02657	Uncharacterized protein. (71 aa)
	VCUG_02307	Uncharacterized protein. (558 aa)
	VCUG_02720	Uncharacterized protein. (71 aa)
	VCUG_02735	Uncharacterized protein. (71 aa)
	VCUG_02687	Uncharacterized protein. (71 aa)
	VCUG_01589	AAA_15 domain-containing protein. (1215 aa)
	VCUG_02125	Uncharacterized protein. (71 aa)
	VCUG_02692	Uncharacterized protein. (71 aa)
	VCUG_02852	ATP-dependent DNA helicase; Belongs to the helicase family. (243 aa)
	VCUG_02847	ATP-dependent DNA helicase; Belongs to the helicase family. (322 aa)
	VCUG_02860	Uncharacterized protein. (145 aa)
	VCUG_02855	Uncharacterized protein. (103 aa)
	VCUG_02839	ATP-dependent DNA helicase; Belongs to the helicase family. (177 aa)
	VCUG_02856	ATP-dependent DNA helicase; Belongs to the helicase family. (356 aa)
	VCUG_02851	ATP-dependent DNA helicase; Belongs to the helicase family. (351 aa)
	VCUG_02306	Uncharacterized protein. (71 aa)
	VCUG_01740	Uncharacterized protein. (91 aa)
	VCUG_02011	Uncharacterized protein. (390 aa)
	VCUG_02378	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (955 aa)
	VCUG_02107	ATP-dependent DNA helicase; Belongs to the helicase family. (168 aa)
	VCUG_02128	OB domain-containing protein. (284 aa)
	VCUG_00047	ERCC4 domain-containing protein. (476 aa)
	VCUG_00756	Uncharacterized protein. (92 aa)

Your Current Organism:

Vavraia culicis

NCBI taxonomy Id: 948595
Other names: V. culicis subsp. floridensis, Vavraia culicis subsp. floridensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
VCUG_00047	VCUG_00230	L2GYU4	L2GX22	ERCC4 domain-containing protein.	Recombination protein rad52.	0.854
VCUG_00047	VCUG_00409	L2GYU4	L2GWW7	ERCC4 domain-containing protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.886
VCUG_00047	VCUG_00424	L2GYU4	L2GWY2	ERCC4 domain-containing protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.978
VCUG_00047	VCUG_00905	L2GYU4	L2GW41	ERCC4 domain-containing protein.	DNA polymerase.	0.657
VCUG_00047	VCUG_00978	L2GYU4	L2GW14	ERCC4 domain-containing protein.	Helicase ATP-binding domain-containing protein.	0.717
VCUG_00047	VCUG_01109	L2GYU4	L2GW04	ERCC4 domain-containing protein.	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.925
VCUG_00047	VCUG_01589	L2GYU4	L2GTC1	ERCC4 domain-containing protein.	AAA_15 domain-containing protein.	0.650
VCUG_00047	VCUG_01677	L2GYU4	L2GU58	ERCC4 domain-containing protein.	BRCA-2_OB1 domain-containing protein.	0.679
VCUG_00047	VCUG_01731	L2GYU4	L2GTT4	ERCC4 domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.739
VCUG_00047	VCUG_02011	L2GYU4	L2GSB5	ERCC4 domain-containing protein.	Uncharacterized protein.	0.695
VCUG_00047	VCUG_02128	L2GYU4	L2GRX5	ERCC4 domain-containing protein.	OB domain-containing protein.	0.684
VCUG_00047	VCUG_02307	L2GYU4	L2GRA9	ERCC4 domain-containing protein.	Uncharacterized protein.	0.808
VCUG_00047	VCUG_02378	L2GYU4	L2GS59	ERCC4 domain-containing protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.983
VCUG_00230	VCUG_00047	L2GX22	L2GYU4	Recombination protein rad52.	ERCC4 domain-containing protein.	0.854
VCUG_00230	VCUG_00409	L2GX22	L2GWW7	Recombination protein rad52.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.992
VCUG_00230	VCUG_00424	L2GX22	L2GWY2	Recombination protein rad52.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.787
VCUG_00230	VCUG_00905	L2GX22	L2GW41	Recombination protein rad52.	DNA polymerase.	0.720
VCUG_00230	VCUG_00978	L2GX22	L2GW14	Recombination protein rad52.	Helicase ATP-binding domain-containing protein.	0.643
VCUG_00230	VCUG_01109	L2GX22	L2GW04	Recombination protein rad52.	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.988
VCUG_00230	VCUG_01589	L2GX22	L2GTC1	Recombination protein rad52.	AAA_15 domain-containing protein.	0.890