45 items (Cebus capucinus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108281866	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (124 aa)
	NPC1L1	NPC1 like intracellular cholesterol transporter 1. (1330 aa)
	MYLK	Uncharacterized protein. (1859 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (832 aa)
	SLC11A2	Solute carrier family 11 member 2. (537 aa)
	OCLN	Occludin. (464 aa)
	ACE2	Angiotensin-converting enzyme. (801 aa)
	SLC23A1	Solute carrier family 23 member 1. (598 aa)
	HAMP	Hepcidin antimicrobial peptide. (84 aa)
	CYBRD1	Cytochrome b reductase 1. (285 aa)
	TJP1	Tight junction protein 1; Belongs to the MAGUK family. (1765 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
	MAP3K9	Mitogen-activated protein kinase kinase kinase 9. (1105 aa)
	FCGBP	Uncharacterized protein. (1093 aa)
	IL10	Interleukin 10. (178 aa)
	ENSCCAP00000034192	Uncharacterized protein. (68 aa)
	ENSCCAP00000032767	Uncharacterized protein. (680 aa)
	IL13	Interleukin 13. (146 aa)
	LOC108297658	Uncharacterized protein. (425 aa)
	NOX1	NADPH oxidase 1. (564 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (395 aa)
	ENSCCAP00000025788	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (131 aa)
	ANPEP	Alanyl aminopeptidase, membrane. (1014 aa)
	CHEK1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
	RHBDL1	Rhomboid-related protein 1; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family. (412 aa)
	CCNB1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (368 aa)
	CDK1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
	ENSCCAP00000021402	VWFD domain-containing protein. (281 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
	LOC108289705	Protein kinase domain-containing protein. (221 aa)
	TRAPPC11	Trafficking protein particle complex 11. (1133 aa)
	SIAH1	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	LOC108303723	Protein kinase domain-containing protein. (251 aa)
	MAP3K10	Mitogen-activated protein kinase kinase kinase. (952 aa)
	IL6	Interleukin 6. (212 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (152 aa)
	CDC25C	Cell division cycle 25C. (459 aa)
	TFF3	Trefoil factor 3. (94 aa)
	LOC108304329	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (428 aa)
	CLDN2	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (231 aa)
	NFIB	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
	ENSCCAP00000001480	Uncharacterized protein. (68 aa)
	CDC40	Cell division cycle 40. (579 aa)

Your Current Organism:

Cebus capucinus

NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE2	ANPEP	ENSCCAP00000008763	ENSCCAP00000025035	Angiotensin-converting enzyme.	Alanyl aminopeptidase, membrane.	0.792
ACE2	IL10	ENSCCAP00000008763	ENSCCAP00000034893	Angiotensin-converting enzyme.	Interleukin 10.	0.576
ACE2	IL6	ENSCCAP00000008763	ENSCCAP00000011907	Angiotensin-converting enzyme.	Interleukin 6.	0.665
ACE2	TNF	ENSCCAP00000008763	ENSCCAP00000020119	Angiotensin-converting enzyme.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.580
ANPEP	ACE2	ENSCCAP00000025035	ENSCCAP00000008763	Alanyl aminopeptidase, membrane.	Angiotensin-converting enzyme.	0.792
CCNB1	CDC25C	ENSCCAP00000022209	ENSCCAP00000011252	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cell division cycle 25C.	0.669
CCNB1	CDK1	ENSCCAP00000022209	ENSCCAP00000021823	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.996
CCNB1	CHEK1	ENSCCAP00000022209	ENSCCAP00000024527	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.441
CCNB1	LOC108289705	ENSCCAP00000022209	ENSCCAP00000019241	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Protein kinase domain-containing protein.	0.967
CCNB1	LOC108297658	ENSCCAP00000022209	ENSCCAP00000029921	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Uncharacterized protein.	0.669
CCNB1	LOC108303723	ENSCCAP00000022209	ENSCCAP00000014045	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Protein kinase domain-containing protein.	0.967
CCNB1	TP53	ENSCCAP00000022209	ENSCCAP00000029525	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.456
CDC25C	CCNB1	ENSCCAP00000011252	ENSCCAP00000022209	Cell division cycle 25C.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.669
CDC25C	CDK1	ENSCCAP00000011252	ENSCCAP00000021823	Cell division cycle 25C.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.894
CDC25C	CHEK1	ENSCCAP00000011252	ENSCCAP00000024527	Cell division cycle 25C.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.947
CDC25C	LOC108289705	ENSCCAP00000011252	ENSCCAP00000019241	Cell division cycle 25C.	Protein kinase domain-containing protein.	0.787
CDC25C	LOC108303723	ENSCCAP00000011252	ENSCCAP00000014045	Cell division cycle 25C.	Protein kinase domain-containing protein.	0.787
CDC25C	LOC108304329	ENSCCAP00000011252	ENSCCAP00000000445	Cell division cycle 25C.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.669
CDK1	CCNB1	ENSCCAP00000021823	ENSCCAP00000022209	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.996
CDK1	CDC25C	ENSCCAP00000021823	ENSCCAP00000011252	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cell division cycle 25C.	0.894