STRINGSTRING
FLT3LG FLT3LG PIK3R5 PIK3R5 TLNRD1 TLNRD1 FGF20 FGF20 FGF5 FGF5 EPHA2 EPHA2 GRAP2 GRAP2 FLT4 FLT4 LCP2 LCP2 CASS4 CASS4 LOC108289748 LOC108289748 TXK TXK PIK3R6 PIK3R6 VCL VCL PGF PGF PIP5K1C PIP5K1C TIE1 TIE1 NGF NGF PTPN12 PTPN12 VEGFB VEGFB NTRK1 NTRK1 PIK3R1 PIK3R1 PIK3CD PIK3CD EPHB3 EPHB3 SH2B2 SH2B2 EFNA4 EFNA4 SRC SRC ENSCCAP00000008780 ENSCCAP00000008780 FGF23 FGF23 IRS2 IRS2 NRG2 NRG2 EPHA7 EPHA7 ANGPT1 ANGPT1 SASH1 SASH1 FLT3 FLT3 ENSCCAP00000009774 ENSCCAP00000009774 VAV3 VAV3 IL34 IL34 SLA2 SLA2 VEGFC VEGFC FRS3 FRS3 INSR INSR TGFB1I1 TGFB1I1 FGF2 FGF2 PLCG1 PLCG1 NRG4 NRG4 ENSCCAP00000011758 ENSCCAP00000011758 EPHA3 EPHA3 EPHA3-2 EPHA3-2 FGF3 FGF3 PDGFRA PDGFRA SOS2 SOS2 EGFR EGFR PIK3R3 PIK3R3 ABL1 ABL1 FGF21 FGF21 NRG3 NRG3 CSK CSK EFNB1 EFNB1 EPHB1 EPHB1 SHC3 SHC3 AXL AXL ABL2 ABL2 BCR BCR GRAP GRAP ANGPT2 ANGPT2 EPGN EPGN TLN1 TLN1 FGF18 FGF18 SOS1 SOS1 PTK2 PTK2 PSTPIP2 PSTPIP2 EFNA1 EFNA1 FGFR1 FGFR1 FGFR4 FGFR4 FGF22 FGF22 RRAS RRAS FGR FGR EPHA5 EPHA5 MERTK MERTK KITLG KITLG PTK2B PTK2B ENSCCAP00000018427 ENSCCAP00000018427 SHC4 SHC4 PDGFA PDGFA NGEF NGEF EFNA5 EFNA5 KDR KDR FGF19 FGF19 EFNB3 EFNB3 SAMD5 SAMD5 MATK MATK ENSCCAP00000019950 ENSCCAP00000019950 EPHB4 EPHB4 GAB1 GAB1 CSF1 CSF1 MEGF10 MEGF10 PIK3CA PIK3CA SH2B3 SH2B3 FGF8 FGF8 VAV2 VAV2 PIK3CB PIK3CB FGFR2 FGFR2 EPHB6 EPHB6 INS INS FER FER KL KL RAPH1 RAPH1 PXN PXN LAT LAT FGFR3 FGFR3 KLB KLB FGF10 FGF10 PIR PIR CBL CBL IGF1R IGF1R APBB1IP APBB1IP PDGFB PDGFB LOC108293848 LOC108293848 EPHA10 EPHA10 GAS6 GAS6 SHC2 SHC2 MET MET SH2D3C SH2D3C PDGFRB PDGFRB FGF17 FGF17 SPRY2 SPRY2 CBLB CBLB GRB2 GRB2 EPHA6 EPHA6 CRK CRK PAG1 PAG1 BCAR1 BCAR1 TGFA TGFA VEGFA VEGFA FGFRL1 FGFRL1 ERBB2 ERBB2 FGF6 FGF6 TEK TEK VAV1 VAV1 PIK3CG PIK3CG KIT KIT TYRO3 TYRO3 PTPN2 PTPN2 PDGFD PDGFD NTRK2 NTRK2 CSF1R CSF1R SH3BP2 SH3BP2 IRS4 IRS4 RAPGEF1 RAPGEF1 EFS EFS FGF16 FGF16 PDGFC PDGFC ERBB3 ERBB3 TEC TEC FGF11 FGF11 SHC1 SHC1 ENSCCAP00000034027 ENSCCAP00000034027 SH2B1 SH2B1 HGF HGF NRG1 NRG1 CRKL CRKL INSRR INSRR FLT1 FLT1 EPHA1 EPHA1 NTRK3 NTRK3 TLN2 TLN2 EPHA8 EPHA8 PIK3R2 PIK3R2 LPXN LPXN IGF1 IGF1 ERBB4 ERBB4 GULP1 GULP1 ITK ITK EREG EREG EFNA3 EFNA3 VEGFD VEGFD ENSCCAP00000037893 ENSCCAP00000037893 EGF EGF AREG AREG YES1 YES1 BLNK BLNK LOC108289749 LOC108289749 NTF3 NTF3 ANGPT4 ANGPT4 EPHA4 EPHA4 FGF7 FGF7 FGF1 FGF1 EPHB2 EPHB2 BDNF BDNF EFNB2 EFNB2 RHOQ RHOQ BTC BTC SRMS SRMS LOC108304702 LOC108304702
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FLT3LGFms related tyrosine kinase 3 ligand. (235 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (878 aa)
TLNRD1Talin rod domain containing 1. (358 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
EPHA2EPH receptor A2. (976 aa)
GRAP2GRB2 related adaptor protein 2. (324 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
LCP2Lymphocyte cytosolic protein 2. (532 aa)
CASS4Cas scaffold protein family member 4. (784 aa)
LOC108289748IRS-type PTB domain-containing protein. (526 aa)
TXKTyrosine-protein kinase. (527 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
VCLVinculin. (1134 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (199 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (707 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (241 aa)
PTPN12Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (779 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1056 aa)
EPHB3EPH receptor B3. (1001 aa)
SH2B2SH2B adaptor protein 2. (678 aa)
EFNA4Ephrin A4; Belongs to the ephrin family. (201 aa)
SRCTyrosine-protein kinase. (542 aa)
ENSCCAP00000008780Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
IRS2Insulin receptor substrate 2. (1361 aa)
NRG2Neuregulin 2. (846 aa)
EPHA7EPH receptor A7. (998 aa)
ANGPT1Angiopoietin 1. (498 aa)
SASH1SAM and SH3 domain containing 1. (1250 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (962 aa)
ENSCCAP00000009774Uncharacterized protein. (758 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
IL34Interleukin 34. (242 aa)
SLA2Src like adaptor 2. (261 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
FRS3Fibroblast growth factor receptor substrate 3. (492 aa)
INSRTyrosine-protein kinase receptor. (1352 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (461 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1302 aa)
NRG4Neuregulin 4. (115 aa)
ENSCCAP00000011758PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (191 aa)
EPHA3Uncharacterized protein. (794 aa)
EPHA3-2Eph LBD domain-containing protein. (286 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
PIK3R3Uncharacterized protein. (577 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
NRG3Neuregulin 3. (719 aa)
CSKTyrosine-protein kinase. (449 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (346 aa)
EPHB1EPH receptor B1. (984 aa)
SHC3SHC adaptor protein 3. (598 aa)
AXLAXL receptor tyrosine kinase. (896 aa)
ABL2Tyrosine-protein kinase. (1182 aa)
BCRBCR activator of RhoGEF and GTPase. (1223 aa)
GRAPGRB2 related adaptor protein. (217 aa)
ANGPT2Angiopoietin 2. (455 aa)
EPGNEpithelial mitogen. (154 aa)
TLN1Talin 1. (2559 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1329 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
PSTPIP2Proline-serine-threonine phosphatase interacting protein 2. (334 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
FGFR1Fibroblast growth factor receptor. (827 aa)
FGFR4Fibroblast growth factor receptor 4. (698 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
RRASRAS related. (218 aa)
FGRTyrosine-protein kinase. (529 aa)
EPHA5EPH receptor A5. (1038 aa)
MERTKReceptor protein-tyrosine kinase. (940 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (268 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (990 aa)
ENSCCAP00000018427SH2 domain-containing protein. (239 aa)
SHC4SHC adaptor protein 4. (628 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (211 aa)
NGEFNeuronal guanine nucleotide exchange factor. (617 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (340 aa)
SAMD5Sterile alpha motif domain containing 5. (175 aa)
MATKTyrosine-protein kinase. (507 aa)
ENSCCAP00000019950Uncharacterized protein. (79 aa)
EPHB4EPH receptor B4. (987 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (551 aa)
MEGF10Multiple EGF like domains 10. (1139 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SH2B3SH2B adaptor protein 3. (576 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
FGFR2Fibroblast growth factor receptor. (782 aa)
EPHB6EPH receptor B6. (1021 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
KLKlotho. (1015 aa)
RAPH1Ras association (RalGDS/AF-6) and pleckstrin homology domains 1. (1306 aa)
PXNPaxillin. (1085 aa)
LATLinker for activation of T cells. (250 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
KLBKlotho beta. (1045 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
PIRPirin; Belongs to the pirin family. (283 aa)
CBLCbl proto-oncogene. (909 aa)
IGF1RTyrosine-protein kinase receptor. (1285 aa)
APBB1IPAmyloid beta precursor protein binding family B member 1 interacting protein. (666 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
LOC108293848Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (854 aa)
EPHA10EPH receptor A10. (1014 aa)
GAS6Growth arrest specific 6. (676 aa)
SHC2Uncharacterized protein. (536 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1404 aa)
SH2D3CSH2 domain containing 3C. (860 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1108 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
CBLBCbl proto-oncogene B. (981 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
EPHA6EPH receptor A6. (1130 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (432 aa)
BCAR1SH3 domain-containing protein. (557 aa)
TGFATransforming growth factor alpha. (165 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (456 aa)
FGFRL1Fibroblast growth factor receptor like 1. (504 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TEKTEK receptor tyrosine kinase. (1069 aa)
VAV1Uncharacterized protein. (899 aa)
PIK3CGUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1102 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
TYRO3TYRO3 protein tyrosine kinase. (890 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (410 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (961 aa)
SH3BP2SH3 domain binding protein 2. (621 aa)
IRS4Insulin receptor substrate 4. (1253 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1103 aa)
EFSEmbryonal Fyn-associated substrate. (562 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1352 aa)
TECTyrosine-protein kinase. (631 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
SHC1SHC adaptor protein 1. (577 aa)
ENSCCAP00000034027Tyrosine-protein kinase. (360 aa)
SH2B1SH2B adaptor protein 1. (756 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
NRG1Neuregulin 1. (713 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
EPHA1EPH receptor A1. (976 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
TLN2Talin 2. (2542 aa)
EPHA8EPH receptor A8. (1006 aa)
PIK3R2Uncharacterized protein. (727 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (390 aa)
IGF1Insulin like growth factor 1. (199 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
GULP1GULP PTB domain containing engulfment adaptor 1. (304 aa)
ITKTyrosine-protein kinase. (620 aa)
EREGEpiregulin. (169 aa)
EFNA3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (238 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (356 aa)
ENSCCAP00000037893Uncharacterized protein. (181 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
AREGAmphiregulin. (275 aa)
YES1Tyrosine-protein kinase. (441 aa)
BLNKB cell linker. (456 aa)
LOC108289749Fibroblast growth factor receptor substrate 2. (508 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (272 aa)
ANGPT4Angiopoietin 4. (503 aa)
EPHA4EPH receptor A4. (949 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
EPHB2EPH receptor B2. (1103 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (329 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (332 aa)
RHOQRas homolog family member Q. (205 aa)
BTCBetacellulin. (178 aa)
SRMSTyrosine-protein kinase. (486 aa)
LOC108304702SH3 domain-containing protein. (816 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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