(91 nodes) Wnt signaling pathway, and Wnt signaling pathway network (Cebus capucinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	FRZB	Frizzled related protein. (325 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	GPC5	Glypican 5; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (571 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (329 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
	CTNNBIP1	Catenin beta interacting protein 1. (81 aa)
	TCF7L1	Transcription factor 7 like 1. (583 aa)
	PRICKLE2	Prickle planar cell polarity protein 2. (900 aa)
	FZD9	Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (592 aa)
	FZD8	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (687 aa)
	FZD4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (543 aa)
	BNIP2	CRAL-TRIO domain-containing protein. (428 aa)
	SPATA13	Uncharacterized protein. (1273 aa)
	AXIN1	Axin 1. (867 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
	ARHGEF4	Uncharacterized protein. (1801 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (547 aa)
	DAAM1	Dishevelled associated activator of morphogenesis 1. (869 aa)
	ENSCCAP00000006235	Uncharacterized protein. (678 aa)
	LOC108292702	CTNNB1_binding domain-containing protein. (169 aa)
	UNC5D	Unc-5 netrin receptor D. (958 aa)
	CER1	Cerberus 1, DAN family BMP antagonist. (267 aa)
	PRICKLE3	Prickle planar cell polarity protein 3. (617 aa)
	GAS7	Growth arrest specific 7. (476 aa)
	AXIN2	Axin 2. (842 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	LEF1	Lymphoid enhancer binding factor 1. (399 aa)
	KREMEN2	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (462 aa)
	SOST	Sclerostin. (213 aa)
	OGFRL1	Opioid growth factor receptor like 1. (450 aa)
	ENSCCAP00000013269	CRAL-TRIO domain-containing protein. (295 aa)
	NLK	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
	NOTUM	Notum, palmitoleoyl-protein carboxylesterase. (503 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (434 aa)
	WNT5B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
	TCF7	Transcription factor 7. (482 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	RYK	Receptor like tyrosine kinase. (613 aa)
	WNT8B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	SFRP2	Secreted frizzled related protein 2. (296 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (943 aa)
	GSKIP	GSK3B interacting protein. (139 aa)
	WIF1	WNT inhibitory factor 1. (379 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	SFRP1	Secreted frizzled related protein 1. (314 aa)
	AMER1	APC membrane recruitment protein 1. (804 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	ATCAY	ATCAY kinesin light chain interacting caytaxin. (379 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
	WNT9A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	WLS	Wnt ligand secretion mediator. (543 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	TCF7L2	Transcription factor 7 like 2. (430 aa)
	PRICKLE1	Prickle planar cell polarity protein 1. (829 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	VANGL1	Vang-like protein. (524 aa)
	APC	APC regulator of WNT signaling pathway. (2860 aa)
	DVL2	Dishevelled segment polarity protein 2. (736 aa)
	APC2	APC regulator of WNT signaling pathway 2. (2172 aa)
	SFRP4	Secreted frizzled related protein 4. (368 aa)
	ANKRD6	Ankyrin repeat domain 6. (717 aa)
	MATN3	Matrilin 3. (487 aa)
	WNT10A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
	NKD1	NKD inhibitor of WNT signaling pathway 1. (470 aa)
	SFRP5	Secreted frizzled related protein 5. (315 aa)
	DKK2	Dickkopf WNT signaling pathway inhibitor 2. (259 aa)
	VANGL2	Vang-like protein. (542 aa)
	PORCN	Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (461 aa)
	DVL3	Uncharacterized protein. (716 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	PRICKLE4	Uncharacterized protein. (386 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1603 aa)
	ROR1	Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
	WNT7B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	CSNK1A1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (365 aa)
	HECW1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1605 aa)
	DKK4	Dickkopf WNT signaling pathway inhibitor 4. (224 aa)
	WNT8A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (317 aa)
	ENSCCAP00000038181	Protein kinase domain-containing protein. (293 aa)
	DAAM2	Dishevelled associated activator of morphogenesis 2. (1077 aa)
	DVL1	Dishevelled segment polarity protein 1. (695 aa)
	KREMEN1	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (471 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	FZD6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
	DKK1	Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
	GSK3A	Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)

Your Current Organism:

Cebus capucinus

NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMER1	APC	ENSCCAP00000024819	ENSCCAP00000028645	APC membrane recruitment protein 1.	APC regulator of WNT signaling pathway.	0.969
AMER1	APC2	ENSCCAP00000024819	ENSCCAP00000029780	APC membrane recruitment protein 1.	APC regulator of WNT signaling pathway 2.	0.930
AMER1	ATCAY	ENSCCAP00000024819	ENSCCAP00000025691	APC membrane recruitment protein 1.	ATCAY kinesin light chain interacting caytaxin.	0.534
AMER1	AXIN1	ENSCCAP00000024819	ENSCCAP00000004082	APC membrane recruitment protein 1.	Axin 1.	0.948
AMER1	AXIN2	ENSCCAP00000024819	ENSCCAP00000010720	APC membrane recruitment protein 1.	Axin 2.	0.849
AMER1	BNIP2	ENSCCAP00000024819	ENSCCAP00000003836	APC membrane recruitment protein 1.	CRAL-TRIO domain-containing protein.	0.534
AMER1	CSNK1A1	ENSCCAP00000024819	ENSCCAP00000037323	APC membrane recruitment protein 1.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.681
AMER1	DVL1	ENSCCAP00000024819	ENSCCAP00000039312	APC membrane recruitment protein 1.	Dishevelled segment polarity protein 1.	0.511
AMER1	ENSCCAP00000013269	ENSCCAP00000024819	ENSCCAP00000013269	APC membrane recruitment protein 1.	CRAL-TRIO domain-containing protein.	0.534
AMER1	ENSCCAP00000038181	ENSCCAP00000024819	ENSCCAP00000038181	APC membrane recruitment protein 1.	Protein kinase domain-containing protein.	0.681
AMER1	GSK3A	ENSCCAP00000024819	ENSCCAP00000040661	APC membrane recruitment protein 1.	Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily.	0.732
AMER1	GSK3B	ENSCCAP00000024819	ENSCCAP00000014550	APC membrane recruitment protein 1.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.827
AMER1	LRP5	ENSCCAP00000024819	ENSCCAP00000035859	APC membrane recruitment protein 1.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.457
AMER1	LRP6	ENSCCAP00000024819	ENSCCAP00000020750	APC membrane recruitment protein 1.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.619
AMER1	OGFRL1	ENSCCAP00000024819	ENSCCAP00000013021	APC membrane recruitment protein 1.	Opioid growth factor receptor like 1.	0.692
AMER1	WNT1	ENSCCAP00000024819	ENSCCAP00000026516	APC membrane recruitment protein 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.504
AMER1	WNT3	ENSCCAP00000024819	ENSCCAP00000023587	APC membrane recruitment protein 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.518
AMER1	WNT3A	ENSCCAP00000024819	ENSCCAP00000001449	APC membrane recruitment protein 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.572
ANKRD6	AXIN1	ENSCCAP00000029895	ENSCCAP00000004082	Ankyrin repeat domain 6.	Axin 1.	0.634
ANKRD6	AXIN2	ENSCCAP00000029895	ENSCCAP00000010720	Ankyrin repeat domain 6.	Axin 2.	0.424