node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATAD5 | EXO1 | ENSCCAP00000011049 | ENSCCAP00000008127 | ATPase family AAA domain containing 5. | Exonuclease 1. | 0.944 |
ATAD5 | FEN1 | ENSCCAP00000011049 | ENSCCAP00000012560 | ATPase family AAA domain containing 5. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.957 |
ATAD5 | RAD51 | ENSCCAP00000011049 | ENSCCAP00000009344 | ATPase family AAA domain containing 5. | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.910 |
ATAD5 | RAD52 | ENSCCAP00000011049 | ENSCCAP00000035913 | ATPase family AAA domain containing 5. | RAD52 homolog, DNA repair protein. | 0.911 |
ATAD5 | RECQL4 | ENSCCAP00000011049 | ENSCCAP00000035648 | ATPase family AAA domain containing 5. | RecQ like helicase 4. | 0.927 |
ATAD5 | WRN | ENSCCAP00000011049 | ENSCCAP00000012032 | ATPase family AAA domain containing 5. | WRN RecQ like helicase. | 0.978 |
EXO1 | ATAD5 | ENSCCAP00000008127 | ENSCCAP00000011049 | Exonuclease 1. | ATPase family AAA domain containing 5. | 0.944 |
EXO1 | FEN1 | ENSCCAP00000008127 | ENSCCAP00000012560 | Exonuclease 1. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.943 |
EXO1 | RAD51 | ENSCCAP00000008127 | ENSCCAP00000009344 | Exonuclease 1. | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.991 |
EXO1 | RAD52 | ENSCCAP00000008127 | ENSCCAP00000035913 | Exonuclease 1. | RAD52 homolog, DNA repair protein. | 0.881 |
EXO1 | RECQL4 | ENSCCAP00000008127 | ENSCCAP00000035648 | Exonuclease 1. | RecQ like helicase 4. | 0.990 |
EXO1 | WRN | ENSCCAP00000008127 | ENSCCAP00000012032 | Exonuclease 1. | WRN RecQ like helicase. | 0.997 |
FEN1 | ATAD5 | ENSCCAP00000012560 | ENSCCAP00000011049 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | ATPase family AAA domain containing 5. | 0.957 |
FEN1 | EXO1 | ENSCCAP00000012560 | ENSCCAP00000008127 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Exonuclease 1. | 0.943 |
FEN1 | RAD51 | ENSCCAP00000012560 | ENSCCAP00000009344 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.943 |
FEN1 | RAD52 | ENSCCAP00000012560 | ENSCCAP00000035913 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | RAD52 homolog, DNA repair protein. | 0.955 |
FEN1 | RECQL4 | ENSCCAP00000012560 | ENSCCAP00000035648 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | RecQ like helicase 4. | 0.950 |
FEN1 | WRN | ENSCCAP00000012560 | ENSCCAP00000012032 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | WRN RecQ like helicase. | 0.999 |
RAD51 | ATAD5 | ENSCCAP00000009344 | ENSCCAP00000011049 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | ATPase family AAA domain containing 5. | 0.910 |
RAD51 | EXO1 | ENSCCAP00000009344 | ENSCCAP00000008127 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | Exonuclease 1. | 0.991 |