STRINGSTRING
LOC108288088 LOC108288088 PINX1 PINX1 TERT TERT INO80 INO80 RUVBL1 RUVBL1 XRCC6 XRCC6 LOC108311527 LOC108311527 SHLD1 SHLD1 ZNF827 ZNF827 ACTL6A ACTL6A GAR1 GAR1 FBXO4 FBXO4 ENSCCAP00000022407 ENSCCAP00000022407 DCLRE1A DCLRE1A PRKDC PRKDC TFPT TFPT ATM ATM INO80D INO80D RTEL1 RTEL1 LOC108299747 LOC108299747 SMC6 SMC6 DKC1 DKC1 SMC5 SMC5 XRCC3 XRCC3 ENSCCAP00000040243 ENSCCAP00000040243 LOC108314810 LOC108314810 ATR ATR RAD50 RAD50 ENSCCAP00000039059 ENSCCAP00000039059 PCNA PCNA LOC108284825 LOC108284825 EXO1 EXO1 XRCC4 XRCC4 LOC108301415 LOC108301415 STN1 STN1 CCNE2 CCNE2 CCNE1 CCNE1 INO80E INO80E RFC1 RFC1 LTO1 LTO1 ERCC1 ERCC1 ENSCCAP00000003630 ENSCCAP00000003630 ENSCCAP00000003626 ENSCCAP00000003626 CTC1 CTC1 SLX1A SLX1A RPA1 RPA1 PARP3 PARP3 LOC108299301 LOC108299301 RAD51 RAD51 NFRKB NFRKB DNA2 DNA2 TERF1 TERF1 SMARCAL1 SMARCAL1 BLM BLM ACD ACD TELO2 TELO2 UCHL5 UCHL5 ACTR8 ACTR8 WRN WRN ZBTB48 ZBTB48 LOC108317875 LOC108317875 SLX4 SLX4 DCLRE1B DCLRE1B TERF2IP TERF2IP RIF1 RIF1 LOC108299438 LOC108299438 RPA3 RPA3 RUVBL2 RUVBL2 ENSCCAP00000015138 ENSCCAP00000015138 ENSCCAP00000016251 ENSCCAP00000016251 XRCC5 XRCC5 ZNF365 ZNF365 ENSCCAP00000031489 ENSCCAP00000031489 BRCA2 BRCA2 NSMCE2 NSMCE2 HUS1 HUS1 LOC108312138 LOC108312138 ENSCCAP00000033299 ENSCCAP00000033299 NHP2 NHP2 ENSCCAP00000034455 ENSCCAP00000034455 NOP10 NOP10 TINF2 TINF2 TEP1 TEP1 POT1 POT1 ZSCAN4 ZSCAN4 MCRS1 MCRS1 LOC108303592 LOC108303592 RECQL4 RECQL4 ENSCCAP00000036866 ENSCCAP00000036866 ENSCCAP00000037361 ENSCCAP00000037361 MAD2L2 MAD2L2 TERF2 TERF2 NBN NBN ENSCCAP00000030953 ENSCCAP00000030953 PARP1 PARP1 WRAP53 WRAP53 PIF1 PIF1 RAD51C RAD51C ERCC4 ERCC4 APEX1 APEX1 UPF1 UPF1 ENSCCAP00000028238 ENSCCAP00000028238
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108288088DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (305 aa)
PINX1G-patch domain-containing protein. (327 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1121 aa)
INO80INO80 complex ATPase subunit. (1556 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
XRCC6SAP domain-containing protein. (534 aa)
LOC108311527Uncharacterized protein. (631 aa)
SHLD1Shieldin complex subunit 1. (205 aa)
ZNF827Zinc finger protein 827. (1084 aa)
ACTL6AActin like 6A; Belongs to the actin family. (429 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (218 aa)
FBXO4F-box protein 4. (387 aa)
ENSCCAP00000022407Uncharacterized protein. (67 aa)
DCLRE1ADRMBL domain-containing protein. (1040 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4130 aa)
TFPTTCF3 fusion partner. (244 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3000 aa)
INO80DINO80 complex subunit D. (1027 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1345 aa)
LOC108299747Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (147 aa)
SMC6Structural maintenance of chromosomes 6. (1097 aa)
DKC1Dyskerin pseudouridine synthase 1. (470 aa)
SMC5SMC_N domain-containing protein. (1102 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa)
ENSCCAP00000040243Ku domain-containing protein. (527 aa)
LOC108314810SAP domain-containing protein. (545 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
RAD50Zinc-hook domain-containing protein. (1312 aa)
ENSCCAP00000039059HSR domain-containing protein. (436 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
LOC108284825Uncharacterized protein. (204 aa)
EXO1Exonuclease 1. (847 aa)
XRCC4X-ray repair cross complementing 4. (334 aa)
LOC108301415Uncharacterized protein. (111 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
INO80EINO80 complex subunit E. (244 aa)
RFC1Replication factor C subunit 1. (1122 aa)
LTO1LTO1 maturation factor of ABCE1. (210 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa)
ENSCCAP00000003630Uncharacterized protein. (64 aa)
ENSCCAP00000003626Uncharacterized protein. (64 aa)
CTC1CST telomere replication complex component 1. (1162 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa)
PARP3Poly [ADP-ribose] polymerase. (532 aa)
LOC108299301Uncharacterized protein. (64 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
NFRKBNuclear factor related to kappaB binding protein. (1299 aa)
DNA2DNA replication helicase/nuclease 2. (1060 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (376 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (957 aa)
BLMBLM RecQ like helicase. (1401 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (509 aa)
TELO2Telomere maintenance 2. (837 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (396 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
WRNWRN RecQ like helicase. (1431 aa)
ZBTB48Zinc finger and BTB domain containing 48. (687 aa)
LOC108317875RECA_2 domain-containing protein. (351 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1826 aa)
DCLRE1BDNA cross-link repair 1B. (540 aa)
TERF2IPTERF2 interacting protein. (399 aa)
RIF1Replication timing regulatory factor 1. (2437 aa)
LOC108299438G-patch domain-containing protein. (331 aa)
RPA3Uncharacterized protein. (121 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (468 aa)
ENSCCAP00000015138TRF domain-containing protein. (250 aa)
ENSCCAP00000016251Uncharacterized protein. (107 aa)
XRCC5X-ray repair cross complementing 5. (785 aa)
ZNF365Zinc finger protein 365. (407 aa)
ENSCCAP00000031489HTH myb-type domain-containing protein. (287 aa)
BRCA2BRCA2 DNA repair associated. (3397 aa)
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (246 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
LOC108312138Uncharacterized protein. (546 aa)
ENSCCAP00000033299Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (142 aa)
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
ENSCCAP00000034455G-patch domain-containing protein. (291 aa)
NOP10NOP10 ribonucleoprotein. (64 aa)
TINF2TERF1 interacting nuclear factor 2. (447 aa)
TEP1Telomerase associated protein 1. (2623 aa)
POT1Protection of telomeres 1. (666 aa)
ZSCAN4Zinc finger and SCAN domain containing 4. (433 aa)
MCRS1Microspherule protein 1. (475 aa)
LOC108303592SAP domain-containing protein. (507 aa)
RECQL4RecQ like helicase 4. (1211 aa)
ENSCCAP00000036866Uncharacterized protein; Belongs to the CGI121/TPRKB family. (88 aa)
ENSCCAP00000037361Uncharacterized protein; Belongs to the CGI121/TPRKB family. (153 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (242 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (527 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa)
ENSCCAP00000030953Uncharacterized protein. (583 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
WRAP53WD repeat containing antisense to TP53. (549 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (708 aa)
RAD51CRECA_2 domain-containing protein. (352 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
UPF1UPF1 RNA helicase and ATPase. (1151 aa)
ENSCCAP00000028238Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (422 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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