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| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1830 aa) |
| | ENSCCAP00000000393 | Uncharacterized protein. (145 aa) |
| | HMCES | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (353 aa) |
| | UVRAG | UV radiation resistance associated. (699 aa) |
| | LIG3 | DNA ligase. (1014 aa) |
| | TENT4A | Terminal nucleotidyltransferase 4A. (793 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (532 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa) |
| | FSBP | Uncharacterized protein. (908 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (709 aa) |
| | ENSCCAP00000002773 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa) |
| | CDCA5 | Cell division cycle associated 5. (261 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (904 aa) |
| | NUCKS1 | Nuclear casein kinase and cyclin dependent kinase substrate 1. (243 aa) |
| | DTX3L | Deltex E3 ubiquitin ligase 3L. (740 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (899 aa) |
| | ANKLE1 | Ankyrin repeat and LEM domain containing 1. (665 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (409 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa) |
| | NHEJ1 | Non-homologous end joining factor 1. (299 aa) |
| | SWI5 | SWI5 homologous recombination repair protein. (172 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | MLH1 | MutL homolog 1. (757 aa) |
| | ESCO2 | Establishment of sister chromatid cohesion N-acetyltransferase 2. (600 aa) |
| | LOC108301415 | Uncharacterized protein. (111 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (552 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (334 aa) |
| | PPP5C | Serine/threonine-protein phosphatase. (499 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (644 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (509 aa) |
| | SIRT6 | Sirtuin 6. (382 aa) |
| | APLF | Aprataxin and PNKP like factor. (502 aa) |
| | MBTD1 | Mbt domain containing 1. (685 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (564 aa) |
| | LOC108284825 | Uncharacterized protein. (204 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (311 aa) |
| | SMARCAD1 | Uncharacterized protein. (1026 aa) |
| | SETMAR | SET domain and mariner transposase fusion gene. (684 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | ACTR5 | Actin related protein 5; Belongs to the actin family. (607 aa) |
| | ENSCCAP00000009590 | Rad21_Rec8 domain-containing protein. (546 aa) |
| | SPO11 | SPO11 initiator of meiotic double stranded breaks. (396 aa) |
| | RAD51B | RAD51 paralog B. (426 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1060 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (957 aa) |
| | TDP2 | Tyrosyl-DNA phosphodiesterase 2. (362 aa) |
| | BLM | BLM RecQ like helicase. (1401 aa) |
| | POLA1 | DNA polymerase. (1391 aa) |
| | FBH1 | F-box DNA helicase 1. (1080 aa) |
| | CHEK2 | Checkpoint kinase 2. (589 aa) |
| | LOC108293350 | Uncharacterized protein. (346 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (636 aa) |
| | REC8 | REC8 meiotic recombination protein. (548 aa) |
| | WRN | WRN RecQ like helicase. (1431 aa) |
| | RAD51AP2 | RAD51 associated protein 2. (1155 aa) |
| | RAD21L1 | RAD21 cohesin complex component like 1. (556 aa) |
| | LOC108317875 | RECA_2 domain-containing protein. (351 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1058 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1826 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | DCLRE1B | DNA cross-link repair 1B. (540 aa) |
| | EPC1 | Enhancer of polycomb homolog. (836 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1212 aa) |
| | ENSCCAP00000014053 | DNA_pol_B domain-containing protein. (262 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (572 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | RPA3 | Uncharacterized protein. (121 aa) |
| | MEIOB | Meiosis specific with OB-fold. (455 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1498 aa) |
| | INTS3 | Integrator complex subunit 3. (1065 aa) |
| | RPA2 | Replication protein A2. (339 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1971 aa) |
| | GGN | Gametogenetin. (641 aa) |
| | RAD54L | RAD54 like. (747 aa) |
| | PRPF19 | Pre-mRNA processing factor 19. (504 aa) |
| | ENSCCAP00000016251 | Uncharacterized protein. (107 aa) |
| | POLN | DNA polymerase nu. (879 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (484 aa) |
| | POLQ | DNA polymerase theta. (2324 aa) |
| | FANCM | FA complementation group M. (1992 aa) |
| | FANCB | FA complementation group B. (859 aa) |
| | NABP1 | Nucleic acid binding protein 1. (123 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (785 aa) |
| | SMC5 | SMC_N domain-containing protein. (1102 aa) |
| | SWSAP1 | SWIM-type zinc finger 7 associated protein 1. (248 aa) |
| | SMC6 | Structural maintenance of chromosomes 6. (1097 aa) |
| | MMS22L | MMS22 like, DNA repair protein. (1241 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (372 aa) |
| | ENSCCAP00000020696 | Uncharacterized protein. (296 aa) |
| | AP5Z1 | Adaptor related protein complex 5 subunit zeta 1. (807 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1016 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3000 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4130 aa) |
| | DCLRE1A | DRMBL domain-containing protein. (1040 aa) |
| | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (361 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (645 aa) |
| | ENSCCAP00000022407 | Uncharacterized protein. (67 aa) |
| | CYREN | Cell cycle regulator of NHEJ. (158 aa) |
| | AP5S1 | Adaptor related protein complex 5 subunit sigma 1. (200 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (2752 aa) |
| | SFPQ | Splicing factor proline and glutamine rich. (707 aa) |
| | PNKP | Polynucleotide kinase 3'-phosphatase. (521 aa) |
| | CCDC155 | Coiled-coil domain containing 155. (560 aa) |
| | ATP23 | Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. (246 aa) |
| | LOC108311527 | Uncharacterized protein. (631 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa) |
| | DDX1 | DEAD-box helicase 1. (740 aa) |
| | PAXX | PAXX non-homologous end joining factor. (204 aa) |
| | NABP2 | Nucleic acid binding protein 2. (187 aa) |
| | SETX | Senataxin. (2678 aa) |
| | TDP1 | Tyrosyl-DNA phosphodiesterase 1. (606 aa) |
| | XRCC6 | SAP domain-containing protein. (534 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (610 aa) |
| | ZSWIM7 | Zinc finger SWIM-type containing 7. (140 aa) |
| | AUNIP | Aurora kinase A and ninein interacting protein. (368 aa) |
| | SMCHD1 | Structural maintenance of chromosomes flexible hinge domain containing 1. (1973 aa) |
| | INO80 | INO80 complex ATPase subunit. (1556 aa) |
| | VCP | Valosin containing protein; Belongs to the AAA ATPase family. (807 aa) |
| | SEM1 | SEM1 26S proteasome complex subunit. (114 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1179 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (719 aa) |
| | ZBTB7A | Zinc finger and BTB domain containing 7A. (584 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (280 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (907 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (543 aa) |
| | ENSCCAP00000027088 | DUF4502 domain-containing protein. (204 aa) |
| | IFFO1 | Intermediate filament family orphan 1; Belongs to the intermediate filament family. (572 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (990 aa) |
| | SFR1 | SWI5 dependent homologous recombination repair protein 1. (240 aa) |
| | HSF2BP | Heat shock transcription factor 2 binding protein. (331 aa) |
| | LOC108305397 | NOPS domain-containing protein. (579 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | SEM1-2 | Uncharacterized protein. (88 aa) |
| | KDM2A | Lysine demethylase 2A. (1161 aa) |
| | CDC45 | Cell division cycle 45. (594 aa) |
| | UBE2V2 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa) |
| | ENSCCAP00000028938 | Uncharacterized protein. (79 aa) |
| | SLFNL1 | Schlafen like 1. (396 aa) |
| | SPIDR | DUF4503 domain-containing protein. (397 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (395 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (350 aa) |
| | MFSD11 | Major facilitator superfamily domain containing 11. (449 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | RAD51C | RECA_2 domain-containing protein. (352 aa) |
| | RNF169 | Ring finger protein 169. (708 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa) |
| | ENSCCAP00000030953 | Uncharacterized protein. (583 aa) |
| | C19orf57 | Chromosome 19 open reading frame 57. (667 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | C14orf39 | Chromosome 14 open reading frame 39. (587 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (321 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3397 aa) |
| | IFFO2 | Intermediate filament family orphan 2; Belongs to the intermediate filament family. (518 aa) |
| | NSMCE2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (246 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | INIP | INTS3 and NABP interacting protein. (87 aa) |
| | LOC108312138 | Uncharacterized protein. (546 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | POLM | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (494 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | RAD21 | RAD21 cohesin complex component. (605 aa) |
| | TM4SF19 | Uncharacterized protein. (208 aa) |
| | LOC108303592 | SAP domain-containing protein. (507 aa) |
| | RECQL4 | RecQ like helicase 4. (1211 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (419 aa) |
| | CDC7 | Cell division cycle 7. (575 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1375 aa) |
| | TRIP13 | Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (413 aa) |
| | MEIOC | Meiosis specific with coiled-coil domain. (953 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (415 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1369 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (242 aa) |
| | FANCD2 | FA complementation group D2. (1442 aa) |
| | NIPBL | Nipped-B protein. (2814 aa) |
| | HELQ | Helicase, POLQ like. (1100 aa) |
| | PARP9 | Poly(ADP-ribose) polymerase family member 9. (817 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (329 aa) |
| | DNTT | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (509 aa) |
| | MARF1 | Meiosis regulator and mRNA stability factor 1. (1741 aa) |
| | ZFYVE26 | Zinc finger FYVE-type containing 26. (2542 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (709 aa) |
| | TNKS1BP1 | Tankyrase 1 binding protein 1. (1734 aa) |
| | LOC108314810 | SAP domain-containing protein. (545 aa) |
| | NSMCE4A | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (385 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1139 aa) |
| | LOC108300233 | Uncharacterized protein. (147 aa) |
| | MTA1 | Metastasis associated 1. (743 aa) |
| | ENSCCAP00000040243 | Ku domain-containing protein. (527 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (310 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (570 aa) |
