Your Input: | |
| | NSMCE1 | NSE1 homolog, SMC5-SMC6 complex component. (266 aa) |
| | ENSCCAP00000002721 | Uncharacterized protein. (196 aa) |
| | FOXP3 | Forkhead box P3. (454 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (709 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa) |
| | FSBP | Uncharacterized protein. (908 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa) |
| | EXOSC3 | Exosome component 3. (310 aa) |
| | LIG3 | DNA ligase. (1014 aa) |
| | KLHDC3 | Kelch domain containing 3. (382 aa) |
| | RAG2 | Recombination activating 2. (527 aa) |
| | ENSCCAP00000000680 | Uncharacterized protein. (253 aa) |
| | ENSCCAP00000000393 | Uncharacterized protein. (145 aa) |
| | ENSCCAP00000000364 | Uncharacterized protein. (223 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (785 aa) |
| | SMC5 | SMC_N domain-containing protein. (1102 aa) |
| | SWSAP1 | SWIM-type zinc finger 7 associated protein 1. (248 aa) |
| | SMC6 | Structural maintenance of chromosomes 6. (1097 aa) |
| | UBR2 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa) |
| | INO80C | YL1_C domain-containing protein. (228 aa) |
| | ENSCCAP00000019892 | Uncharacterized protein. (193 aa) |
| | MMS22L | MMS22 like, DNA repair protein. (1241 aa) |
| | CNTD1 | Cyclin N-terminal domain containing 1. (330 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (372 aa) |
| | HMGB1 | Uncharacterized protein. (187 aa) |
| | RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (649 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1345 aa) |
| | SWAP70 | PH domain-containing protein. (577 aa) |
| | AP5Z1 | Adaptor related protein complex 5 subunit zeta 1. (807 aa) |
| | INO80D | INO80 complex subunit D. (1027 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1016 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3000 aa) |
| | MLH3 | MutL homolog 3. (1456 aa) |
| | TFPT | TCF3 fusion partner. (244 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4130 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (645 aa) |
| | ENSCCAP00000022407 | Uncharacterized protein. (67 aa) |
| | CYREN | Cell cycle regulator of NHEJ. (158 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (581 aa) |
| | HDGFL2 | HDGF like 2. (671 aa) |
| | AP5S1 | Adaptor related protein complex 5 subunit sigma 1. (200 aa) |
| | ENSCCAP00000022918 | Uncharacterized protein. (222 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (2752 aa) |
| | SFPQ | Splicing factor proline and glutamine rich. (707 aa) |
| | ACTL6A | Actin like 6A; Belongs to the actin family. (429 aa) |
| | UNG | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (313 aa) |
| | CCDC155 | Coiled-coil domain containing 155. (560 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (239 aa) |
| | TOP2B | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1619 aa) |
| | ENSCCAP00000024430 | Uncharacterized protein. (265 aa) |
| | LOC108311527 | Uncharacterized protein. (631 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa) |
| | ENSCCAP00000024677 | RING-type domain-containing protein. (259 aa) |
| | CCDC36 | Coiled-coil domain containing 36. (600 aa) |
| | NABP2 | Nucleic acid binding protein 2. (187 aa) |
| | AICDA | Activation induced cytidine deaminase. (183 aa) |
| | SETX | Senataxin. (2678 aa) |
| | XRCC6 | SAP domain-containing protein. (534 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | RPAIN | RPA interacting protein. (230 aa) |
| | ZSWIM7 | Zinc finger SWIM-type containing 7. (140 aa) |
| | ENSCCAP00000025732 | Uncharacterized protein. (201 aa) |
| | AUNIP | Aurora kinase A and ninein interacting protein. (368 aa) |
| | INO80 | INO80 complex ATPase subunit. (1556 aa) |
| | SEM1 | SEM1 26S proteasome complex subunit. (114 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1179 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (280 aa) |
| | LOC108306685 | Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (188 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (907 aa) |
| | ENSCCAP00000026887 | Uncharacterized protein. (295 aa) |
| | HMGB3 | Uncharacterized protein. (202 aa) |
| | ENSCCAP00000027008 | PH domain-containing protein. (494 aa) |
| | ENSCCAP00000027088 | DUF4502 domain-containing protein. (204 aa) |
| | ENSCCAP00000027099 | Uncharacterized protein. (296 aa) |
| | ENSCCAP00000027377 | YL1_C domain-containing protein. (212 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (990 aa) |
| | SFR1 | SWI5 dependent homologous recombination repair protein 1. (240 aa) |
| | HROB | Chromosome 17 open reading frame 53. (636 aa) |
| | HSF2BP | Heat shock transcription factor 2 binding protein. (331 aa) |
| | LOC108305397 | NOPS domain-containing protein. (579 aa) |
| | ENSCCAP00000028012 | Uncharacterized protein. (307 aa) |
| | LOC108288088 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (305 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | SEM1-2 | Uncharacterized protein. (88 aa) |
| | CDC45 | Cell division cycle 45. (594 aa) |
| | ENSCCAP00000028938 | Uncharacterized protein. (79 aa) |
| | DEF6 | DEF6 guanine nucleotide exchange factor. (694 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1289 aa) |
| | SPIDR | DUF4503 domain-containing protein. (397 aa) |
| | PAXIP1 | PAX interacting protein 1. (1064 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | KIN | Kin17 DNA and RNA binding protein. (360 aa) |
| | ENSCCAP00000029615 | Mnd1 domain-containing protein. (155 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (350 aa) |
| | C1orf146 | Chromosome 1 open reading frame 146. (180 aa) |
| | APEX1 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa) |
| | ENSCCAP00000030160 | Uncharacterized protein. (185 aa) |
| | SHOC1 | Shortage in chiasmata 1. (1444 aa) |
| | HFM1 | Helicase for meiosis 1. (1433 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1526 aa) |
| | RAD51C | RECA_2 domain-containing protein. (352 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (708 aa) |
| | ENSCCAP00000030953 | Uncharacterized protein. (583 aa) |
| | PAGR1 | PAXIP1 associated glutamate rich protein 1. (254 aa) |
| | C19orf57 | Chromosome 19 open reading frame 57. (667 aa) |
| | MND1 | Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (207 aa) |
| | ENSCCAP00000031131 | Uncharacterized protein. (267 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | TEX11 | Uncharacterized protein. (494 aa) |
| | C14orf39 | Chromosome 14 open reading frame 39. (587 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3397 aa) |
| | NSMCE2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (246 aa) |
| | SUPV3L1 | Suv3 like RNA helicase. (766 aa) |
| | MSH5 | DNA_MISMATCH_REPAIR_2 domain-containing protein. (833 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | INIP | INTS3 and NABP interacting protein. (87 aa) |
| | SYCP1 | Synaptonemal complex protein 1. (976 aa) |
| | INO80B | PAPA-1 domain-containing protein. (372 aa) |
| | TCF3 | Transcription factor 3. (695 aa) |
| | ENSCCAP00000033006 | UDG domain-containing protein. (282 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | MSH4 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (870 aa) |
| | POLM | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (494 aa) |
| | PSMC3IP | PSMC3 interacting protein. (217 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (692 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | RAD21 | RAD21 cohesin complex component. (605 aa) |
| | TM4SF19 | Uncharacterized protein. (208 aa) |
| | SYCE3 | Synaptonemal complex central element protein 3. (88 aa) |
| | ENSCCAP00000034559 | Mnd1 domain-containing protein. (127 aa) |
| | TEP1 | Telomerase associated protein 1. (2623 aa) |
| | MCRS1 | Microspherule protein 1. (475 aa) |
| | LOC108303592 | SAP domain-containing protein. (507 aa) |
| | RECQL4 | RecQ like helicase 4. (1211 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (419 aa) |
| | CDC7 | Cell division cycle 7. (575 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1375 aa) |
| | ENSCCAP00000036866 | Uncharacterized protein; Belongs to the CGI121/TPRKB family. (88 aa) |
| | TRIP13 | Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (413 aa) |
| | ENSCCAP00000037361 | Uncharacterized protein; Belongs to the CGI121/TPRKB family. (153 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (904 aa) |
| | KIAA1841 | KIAA1841. (718 aa) |
| | FANCD2 | FA complementation group D2. (1442 aa) |
| | NIPBL | Nipped-B protein. (2814 aa) |
| | HELQ | Helicase, POLQ like. (1100 aa) |
| | LOC108306798 | Uncharacterized protein. (188 aa) |
| | CENPS | Centromere protein S. (138 aa) |
| | CORT | Cortistatin. (105 aa) |
| | ZFYVE26 | Zinc finger FYVE-type containing 26. (2542 aa) |
| | REC114 | REC114 meiotic recombination protein. (265 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (709 aa) |
| | DCAF1 | DDB1 and CUL4 associated factor 1. (1482 aa) |
| | LOC108314810 | SAP domain-containing protein. (545 aa) |
| | RNF212 | Ring finger protein 212. (253 aa) |
| | NSMCE4A | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (385 aa) |
| | BATF | Basic leucine zipper ATF-like transcription factor. (125 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1139 aa) |
| | LOC108300233 | Uncharacterized protein. (147 aa) |
| | ENSCCAP00000040243 | Ku domain-containing protein. (527 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (310 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa) |
| | NABP1 | Nucleic acid binding protein 1. (123 aa) |
| | POGZ | Pogo transposable element derived with ZNF domain. (1410 aa) |
| | ENSCCAP00000017906 | Uncharacterized protein. (188 aa) |
| | FANCB | FA complementation group B. (859 aa) |
| | FANCM | FA complementation group M. (1992 aa) |
| | MEI4 | Meiotic double-stranded break formation protein 4. (384 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1830 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (484 aa) |
| | BCL6 | BCL6 transcription repressor. (706 aa) |
| | TCF7 | Transcription factor 7. (482 aa) |
| | ENSCCAP00000016694 | RRM domain-containing protein. (143 aa) |
| | POLN | DNA polymerase nu. (879 aa) |
| | TOP2A | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa) |
| | ENSCCAP00000016251 | Uncharacterized protein. (107 aa) |
| | RAD54L | RAD54 like. (747 aa) |
| | ANKRD31 | Ankyrin repeat domain 31. (1929 aa) |
| | LOC108291481 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (465 aa) |
| | RPA2 | Replication protein A2. (339 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (468 aa) |
| | INTS3 | Integrator complex subunit 3. (1065 aa) |
| | MEIOB | Meiosis specific with OB-fold. (455 aa) |
| | RPA3 | Uncharacterized protein. (121 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | ENSCCAP00000014053 | DNA_pol_B domain-containing protein. (262 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1212 aa) |
| | EPC1 | Enhancer of polycomb homolog. (836 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1826 aa) |
| | CCNB1IP1 | RING-type domain-containing protein. (277 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1058 aa) |
| | LOC108317875 | RECA_2 domain-containing protein. (351 aa) |
| | RAD21L1 | RAD21 cohesin complex component like 1. (556 aa) |
| | RAD51AP2 | RAD51 associated protein 2. (1155 aa) |
| | WRN | WRN RecQ like helicase. (1431 aa) |
| | ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa) |
| | REC8 | REC8 meiotic recombination protein. (548 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (636 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (399 aa) |
| | FBH1 | F-box DNA helicase 1. (1080 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1686 aa) |
| | RNF212B | Ring finger protein 212B. (275 aa) |
| | CCR6 | C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (377 aa) |
| | BLM | BLM RecQ like helicase. (1401 aa) |
| | MSH3 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1124 aa) |
| | ENSCCAP00000010022 | Uncharacterized protein. (262 aa) |
| | CENPX | Uncharacterized protein. (81 aa) |
| | NFRKB | Nuclear factor related to kappaB binding protein. (1299 aa) |
| | RAD51B | RAD51 paralog B. (426 aa) |
| | SPO11 | SPO11 initiator of meiotic double stranded breaks. (396 aa) |
| | ENSCCAP00000009590 | Rad21_Rec8 domain-containing protein. (546 aa) |
| | ACTR5 | Actin related protein 5; Belongs to the actin family. (607 aa) |
| | BCL11B | BAF chromatin remodeling complex subunit BCL11B. (467 aa) |
| | ENSCCAP00000009412 | Uncharacterized protein. (206 aa) |
| | LIG1 | DNA ligase. (919 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | CD40LG | CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (311 aa) |
| | LOC108284825 | Uncharacterized protein. (204 aa) |
| | ENSCCAP00000008521 | Uncharacterized protein. (210 aa) |
| | LOC108297589 | Uncharacterized protein. (430 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (564 aa) |
| | MBTD1 | Mbt domain containing 1. (685 aa) |
| | EXO1 | Exonuclease 1. (847 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (509 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (644 aa) |
| | STAT6 | Signal transducer and activator of transcription. (847 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (334 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (778 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (552 aa) |
| | C11orf80 | Chromosome 11 open reading frame 80. (578 aa) |
| | LOC108301415 | Uncharacterized protein. (111 aa) |
| | ENSCCAP00000005750 | Uncharacterized protein. (214 aa) |
| | PGBD5 | PiggyBac transposable element derived 5. (524 aa) |
| | ENSCCAP00000005487 | Uncharacterized protein. (196 aa) |
| | RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa) |
| | LOC108290290 | HMG box domain-containing protein. (132 aa) |
| | MLH1 | MutL homolog 1. (757 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | INO80E | INO80 complex subunit E. (244 aa) |
| | SWI5 | SWI5 homologous recombination repair protein. (172 aa) |
| | NHEJ1 | Non-homologous end joining factor 1. (299 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa) |
| | ANKLE1 | Ankyrin repeat and LEM domain containing 1. (665 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (899 aa) |
| | ENSCCAP00000003988 | Uncharacterized protein. (234 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | NUCKS1 | Nuclear casein kinase and cyclin dependent kinase substrate 1. (243 aa) |
