STRINGSTRING
ATIC ATIC LOC108293271 LOC108293271 LOC108306195 LOC108306195 ADSL ADSL ADSS2 ADSS2 ENSCCAP00000005127 ENSCCAP00000005127 DLG1 DLG1 NT5C1A NT5C1A AMPD1 AMPD1 ENSCCAP00000006951 ENSCCAP00000006951 IMPDH1 IMPDH1 NT5E NT5E GDA GDA IMPDH2 IMPDH2 PAICS PAICS XDH XDH GMPR2 GMPR2 GUK1 GUK1 LOC108310960 LOC108310960 LOC108308296 LOC108308296 CASK CASK HPRT1 HPRT1 APRT APRT MAGI3 MAGI3 GMPS GMPS NT5C NT5C AMPD3 AMPD3 ADA ADA AK2 AK2 LOC108292926 LOC108292926 AMPD2 AMPD2 PFAS PFAS PNP PNP AK9 AK9 AK4 AK4 NT5C2 NT5C2 ENSCCAP00000016083 ENSCCAP00000016083 DLG2 DLG2 CARD11 CARD11 NUDT2 NUDT2 NT5DC1 NT5DC1 GART GART AK3 AK3 LOC108308844 LOC108308844 LRGUK LRGUK ADK ADK PPAT PPAT ADSS1 ADSS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATICMGS domain-containing protein. (557 aa)
LOC108293271Protein kinase domain-containing protein. (158 aa)
LOC108306195MGS domain-containing protein. (593 aa)
ADSLAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (498 aa)
ADSS2Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
ENSCCAP00000005127A_deaminase domain-containing protein. (260 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
NT5C1A5'-nucleotidase, cytosolic IA. (371 aa)
AMPD1AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (775 aa)
ENSCCAP00000006951Uncharacterized protein; Belongs to the adenylate kinase family. (186 aa)
IMPDH1Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (626 aa)
NT5E5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa)
GDAGuanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (472 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
PAICSAIRC domain-containing protein. (453 aa)
XDHXanthine dehydrogenase. (1333 aa)
GMPR2GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (358 aa)
GUK1Guanylate kinase 1. (235 aa)
LOC108310960Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)
LOC108308296Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (232 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (510 aa)
HPRT1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
APRTAdenine phosphoribosyltransferase. (180 aa)
MAGI3Membrane associated guanylate kinase, WW and PDZ domain containing 3. (1483 aa)
GMPSUncharacterized protein. (693 aa)
NT5C5', 3'-nucleotidase, cytosolic. (201 aa)
AMPD3AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (777 aa)
ADAA_deaminase domain-containing protein. (363 aa)
AK2ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (201 aa)
LOC108292926MGS domain-containing protein. (536 aa)
AMPD2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (880 aa)
PFASPhosphoribosylformylglycinamidine synthase. (1276 aa)
PNPPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
AK9Adenylate kinase 9. (1905 aa)
AK4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa)
NT5C25'-nucleotidase, cytosolic II. (558 aa)
ENSCCAP00000016083GMP_synt_C domain-containing protein. (198 aa)
DLG2Discs large MAGUK scaffold protein 2. (961 aa)
CARD11Caspase recruitment domain family member 11. (1156 aa)
NUDT2Nudix hydrolase 2. (147 aa)
NT5DC15'-nucleotidase domain containing 1. (455 aa)
GARTTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (874 aa)
AK3GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (227 aa)
LOC108308844ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (231 aa)
LRGUKLeucine rich repeats and guanylate kinase domain containing. (826 aa)
ADKAdenosine kinase. (362 aa)
PPATAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (514 aa)
ADSS1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (457 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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