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| | ENSCCAP00000000830 | DJ-1_PfpI domain-containing protein. (140 aa) |
| | SOX9 | SRY-box transcription factor 9. (509 aa) |
| | FABP1 | Fatty acid binding protein 1. (127 aa) |
| | LONP2 | Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. (852 aa) |
| | BMP2 | Bone morphogenetic protein 2. (396 aa) |
| | SREBF1 | Sterol regulatory element binding transcription factor 1. (1185 aa) |
| | LOC108304643 | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (310 aa) |
| | STAR | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa) |
| | ABCD1 | ATP binding cassette subfamily D member 1. (744 aa) |
| | ENSCCAP00000004561 | Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (154 aa) |
| | PDK3 | Protein-serine/threonine kinase. (415 aa) |
| | NR1H2 | Nuclear receptor subfamily 1 group H member 2. (459 aa) |
| | FMO1 | Flavin-containing monooxygenase. (470 aa) |
| | CYP7A1 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa) |
| | NR1H4 | Nuclear receptor subfamily 1 group H member 4. (486 aa) |
| | ADM | Adrenomedullin. (184 aa) |
| | ABCB11 | ATP binding cassette subfamily B member 11. (1321 aa) |
| | LOC108297694 | ANK_REP_REGION domain-containing protein. (307 aa) |
| | PLIN5 | Perilipin; Belongs to the perilipin family. (459 aa) |
| | REST | RE1 silencing transcription factor. (1100 aa) |
| | LOC108285741 | Uncharacterized protein. (491 aa) |
| | PARK7 | DJ-1_PfpI domain-containing protein. (189 aa) |
| | IRS2 | Insulin receptor substrate 2. (1361 aa) |
| | LOC108298171 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (520 aa) |
| | ENSCCAP00000009736 | DJ-1_PfpI domain-containing protein. (174 aa) |
| | ENSCCAP00000010332 | Uncharacterized protein. (139 aa) |
| | PANK2 | Pantothenate kinase 2. (550 aa) |
| | DKK3 | Dickkopf WNT signaling pathway inhibitor 3. (350 aa) |
| | AVPR1A | Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (418 aa) |
| | WNT4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | PDK1 | Protein-serine/threonine kinase. (447 aa) |
| | LOC108315475 | C2 domain-containing protein. (141 aa) |
| | AVP | Arginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa) |
| | BMP5 | Bone morphogenetic protein 5. (454 aa) |
| | BMP6 | Bone morphogenetic protein 6. (508 aa) |
| | ENSCCAP00000013029 | CCDC144C domain-containing protein. (1062 aa) |
| | CLCN2 | Chloride channel protein. (899 aa) |
| | LOC108310640 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (534 aa) |
| | APOC2 | Apolipoprotein C2. (93 aa) |
| | SLC45A3 | Solute carrier family 45 member 3. (553 aa) |
| | ENSCCAP00000013848 | DJ-1_PfpI domain-containing protein. (153 aa) |
| | PPARGC1A | PPARG coactivator 1 alpha. (812 aa) |
| | NR4A3 | Nuclear receptor subfamily 4 group A member 3. (723 aa) |
| | NR1H3 | Nuclear receptor subfamily 1 group H member 3. (447 aa) |
| | ABCD2 | ATP binding cassette subfamily D member 2. (740 aa) |
| | ACACB | Acetyl-CoA carboxylase beta. (2458 aa) |
| | CPT1A | Carnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa) |
| | COQ3 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (369 aa) |
| | MID1IP1 | MID1 interacting protein 1. (173 aa) |
| | DGAT2 | Diacylglycerol O-acyltransferase 2. (382 aa) |
| | PIBF1 | Progesterone immunomodulatory binding factor 1. (757 aa) |
| | CD74 | CD74 molecule. (308 aa) |
| | WDTC1 | WD and tetratricopeptide repeats 1. (693 aa) |
| | FGFR4 | Fibroblast growth factor receptor 4. (698 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1830 aa) |
| | NCOR2 | Nuclear receptor corepressor 2. (2513 aa) |
| | TRIB3 | Tribbles pseudokinase 3. (385 aa) |
| | ATP2B4 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1224 aa) |
| | ENSCCAP00000018890 | ANK_REP_REGION domain-containing protein. (530 aa) |
| | FGF19 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa) |
| | PPARG | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa) |
| | DAB2 | DAB adaptor protein 2. (767 aa) |
| | H6PD | Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (802 aa) |
| | LOC108298172 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (556 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | GHSR | Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa) |
| | MALRD1 | MAM and LDL receptor class A domain containing 1. (2161 aa) |
| | TYSND1 | Serine protease; Belongs to the peptidase S1B family. (566 aa) |
| | INSIG1 | Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (277 aa) |
| | PTGS2 | Prostaglandin-endoperoxide synthase 2. (604 aa) |
| | ENSCCAP00000022660 | Uncharacterized protein. (404 aa) |
| | STARD4 | StAR related lipid transfer domain containing 4. (206 aa) |
| | PPARA | Peroxisome proliferator activated receptor alpha. (468 aa) |
| | IL1B | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa) |
| | SIRT1 | Sirtuin 1. (446 aa) |
| | SLC22A13 | Solute carrier family 22 member 13. (551 aa) |
| | FMO4 | Dimethylaniline monooxygenase [N-oxide-forming]. (557 aa) |
| | PRKAG2 | Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa) |
| | PRKCE | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa) |
| | MFSD2A | Major facilitator superfamily domain containing 2A. (543 aa) |
| | PDK4 | Protein-serine/threonine kinase. (411 aa) |
| | SIRT4 | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa) |
| | EIF6 | Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (253 aa) |
| | DGKQ | Diacylglycerol kinase. (938 aa) |
| | ATCAY | ATCAY kinesin light chain interacting caytaxin. (379 aa) |
| | PPTC7 | Protein phosphatase; Belongs to the PP2C family. (306 aa) |
| | ADIPOQ | Adiponectin, C1Q and collagen domain containing. (244 aa) |
| | SLC7A7 | Solute carrier family 7 member 7. (510 aa) |
| | ENSCCAP00000027455 | Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (91 aa) |
| | FH | Fumarate hydratase. (510 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1. (615 aa) |
| | ACMSD | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (336 aa) |
| | GIP | Gastric inhibitory polypeptide. (153 aa) |
| | PDK2 | Protein-serine/threonine kinase. (407 aa) |
| | ETFBKMT | Electron transfer flavoprotein subunit beta lysine methyltransferase. (262 aa) |
| | APOA5 | Apolipoprotein A5. (366 aa) |
| | FMO2 | Dimethylaniline monooxygenase [N-oxide-forming]. (535 aa) |
| | MLXIPL | MLX interacting protein like. (852 aa) |
| | SLC7A11 | Solute carrier family 7 member 11. (501 aa) |
| | NCOR1 | SANT domain-containing protein. (2281 aa) |
| | LPGAT1 | Lysophosphatidylglycerol acyltransferase 1. (370 aa) |
| | MTLN | Mitoregulin. (123 aa) |
| | FABP5 | FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa) |
| | PPARD | Peroxisome proliferator activated receptor delta. (441 aa) |
| | ERLIN2 | ER lipid raft associated 2. (339 aa) |
| | PRMT3 | Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (531 aa) |
| | LOC108293549 | Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (234 aa) |
| | PROX1 | Prospero homeobox 1. (737 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (489 aa) |
| | CES4A | Carboxylesterase 4A. (479 aa) |
| | ERFE | Erythroferrone. (334 aa) |
| | RDH10 | Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa) |
| | PLA2G3 | Phospholipase A2 group III. (509 aa) |
| | CLN3 | Battenin. (491 aa) |
| | ERLIN1 | ER lipid raft associated 1. (345 aa) |
| | BCKDK | Protein-serine/threonine kinase. (412 aa) |
| | ENSCCAP00000038186 | DJ-1_PfpI domain-containing protein. (132 aa) |
| | LOC108305208 | DJ-1_PfpI domain-containing protein. (149 aa) |
| | MLYCD | Malonyl-CoA decarboxylase. (493 aa) |
| | SIRT5 | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (309 aa) |
| | SCAP | SREBF chaperone. (1267 aa) |
| | FABP3 | FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa) |
| | EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa) |
| | APPL2 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (664 aa) |
