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CYB5R3 CYB5R3 LOC108305585 LOC108305585 HMGCS1 HMGCS1 FDPS FDPS LOC108289171 LOC108289171 ENSCCAP00000015513 ENSCCAP00000015513 APOA1 APOA1 NSDHL NSDHL ENSCCAP00000011033 ENSCCAP00000011033 ENSCCAP00000010925 ENSCCAP00000010925 CYB5R2 CYB5R2 DHCR7 DHCR7 MVD MVD PMVK PMVK EBP EBP FDFT1 FDFT1 HMGCR HMGCR LSS LSS CYP51A1 CYP51A1 R3HDM4 R3HDM4 MVK MVK LBR LBR SREBF1 SREBF1 NPC1L1 NPC1L1 PLPP6 PLPP6 SC5D SC5D CFTR CFTR ARV1 ARV1 CYB5R1 CYB5R1 MSMO1 MSMO1 PRKAA2 PRKAA2 ENSCCAP00000033203 ENSCCAP00000033203 ENSCCAP00000033131 ENSCCAP00000033131 ACLY ACLY TM7SF2 TM7SF2 G6PD G6PD ERG28 ERG28 HMGCS2 HMGCS2 LOC108316220 LOC108316220 APOA5 APOA5 ENSCCAP00000024582 ENSCCAP00000024582 IDI1 IDI1 PRKAG2 PRKAG2 INSIG2 INSIG2 HSD17B7 HSD17B7 INSIG1 INSIG1 PRKAA1 PRKAA1 ENSCCAP00000021515 ENSCCAP00000021515 DHCR24 DHCR24 SQLE SQLE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CYB5R3NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (246 aa)
LOC108305585Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (386 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
FDPSUncharacterized protein. (236 aa)
LOC108289171Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (345 aa)
ENSCCAP00000015513Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (229 aa)
APOA1Apolipoprotein A1. (267 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (373 aa)
ENSCCAP00000011033Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (345 aa)
ENSCCAP00000010925Uncharacterized protein; Belongs to the cytochrome P450 family. (460 aa)
CYB5R2NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (276 aa)
DHCR77-dehydrocholesterol reductase. (475 aa)
MVDDiphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (400 aa)
PMVKPhosphomevalonate kinase. (192 aa)
EBPEXPERA domain-containing protein. (230 aa)
FDFT1Farnesyl-diphosphate farnesyltransferase 1. (468 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (821 aa)
LSSTerpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (737 aa)
CYP51A1Uncharacterized protein; Belongs to the cytochrome P450 family. (509 aa)
R3HDM4R3H domain containing 4. (275 aa)
MVKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (346 aa)
LBRLamin B receptor. (615 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1185 aa)
NPC1L1NPC1 like intracellular cholesterol transporter 1. (1330 aa)
PLPP6Phospholipid phosphatase 6. (296 aa)
SC5DSterol-C5-desaturase; Belongs to the sterol desaturase family. (299 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
ARV1ARV1 homolog, fatty acid homeostasis modulator. (271 aa)
CYB5R1NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (305 aa)
MSMO1Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. (293 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
ENSCCAP00000033203Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (390 aa)
ENSCCAP00000033131Uncharacterized protein. (221 aa)
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1112 aa)
TM7SF2Transmembrane 7 superfamily member 2. (418 aa)
G6PDUncharacterized protein. (560 aa)
ERG28Ergosterol biosynthesis 28 homolog. (140 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (466 aa)
LOC108316220Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (501 aa)
APOA5Apolipoprotein A5. (366 aa)
ENSCCAP00000024582FAD-binding PCMH-type domain-containing protein. (470 aa)
IDI1Isopentenyl-diphosphate delta isomerase 1. (227 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
HSD17B7Hydroxysteroid 17-beta dehydrogenase 7. (330 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (277 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
ENSCCAP00000021515Nudix hydrolase domain-containing protein. (176 aa)
DHCR24FAD-binding PCMH-type domain-containing protein. (516 aa)
SQLESqualene epoxidase. (581 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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