STRINGSTRING
ROR1 ROR1 SRMS SRMS RELN RELN CLK2 CLK2 EIF2AK2 EIF2AK2 EPHB2 EPHB2 EPHA4 EPHA4 NRP1 NRP1 HPX HPX YES1 YES1 DYRK2 DYRK2 EGF EGF BMX BMX DYRK3 DYRK3 ITK ITK MAPK3 MAPK3 ERBB4 ERBB4 IL5 IL5 EPHA8 EPHA8 CHKA CHKA FES FES NTRK3 NTRK3 EPHA1 EPHA1 FLT1 FLT1 INSRR INSRR MAP3K9 MAP3K9 PTK6 PTK6 DDR2 DDR2 CD3E CD3E ENSCCAP00000034027 ENSCCAP00000034027 HIPK2 HIPK2 NOD2 NOD2 IL15 IL15 CRIM1 CRIM1 TEC TEC TTN TTN ERBB3 ERBB3 ROS1 ROS1 CSF1R CSF1R NTRK2 NTRK2 ALK ALK TYRO3 TYRO3 KIT KIT WEE2 WEE2 TEK TEK TESK1 TESK1 PKDCC PKDCC ERBB2 ERBB2 FGFRL1 FGFRL1 HIPK3 HIPK3 JAK3 JAK3 LEP LEP MAP2K4 MAP2K4 EPHA6 EPHA6 LIF LIF PDGFRB PDGFRB CD4 CD4 TNK2 TNK2 MET MET BRAF BRAF EPHA10 EPHA10 RIPK2 RIPK2 TTK TTK LRRK1 LRRK1 PDGFB PDGFB IGF1R IGF1R ENSCCAP00000025361 ENSCCAP00000025361 LCK LCK TTBK1 TTBK1 MAP2K5 MAP2K5 DYRK4 DYRK4 FGFR3 FGFR3 PTPRC PTPRC DSTYK DSTYK PRLR PRLR LTK LTK WEE1 WEE1 FER FER MST1R MST1R EPHB6 EPHB6 FGFR2 FGFR2 ZAP70 ZAP70 BAZ1B BAZ1B FYN FYN ROR2 ROR2 RPS6KA5 RPS6KA5 BAZ1A BAZ1A EPHB4 EPHB4 ABI2 ABI2 MATK MATK TNK1 TNK1 CLK4 CLK4 DDR1 DDR1 EFNB3 EFNB3 ABI1 ABI1 MAP3K11 MAP3K11 MAP2K6 MAP2K6 KDR KDR PTK2B PTK2B EFEMP1 EFEMP1 KITLG KITLG MERTK MERTK EPHA5 EPHA5 FGR FGR SCYL1 SCYL1 RYK RYK MAP2K3 MAP2K3 PBK PBK MELK MELK LYN LYN NRP2 NRP2 MAP2K7 MAP2K7 FGFR4 FGFR4 FGFR1 FGFR1 BLK BLK PTK2 PTK2 PIBF1 PIBF1 IL2 IL2 PDGFRL PDGFRL PEAK1 PEAK1 AATK AATK BCR BCR ABL2 ABL2 AXL AXL FRK FRK EPHB1 EPHB1 CNTF CNTF CSK CSK HIPK1 HIPK1 ABL1 ABL1 LOC108282680 LOC108282680 DYRK1A DYRK1A MAP3K10 MAP3K10 STK16 STK16 EGFR EGFR PDGFRA PDGFRA EPHA3-2 EPHA3-2 EPHA3 EPHA3 TYK2 TYK2 IL4 IL4 INSR INSR PTPN4 PTPN4 JAK2 JAK2 FLT3 FLT3 ENSCCAP00000009738 ENSCCAP00000009738 EPHA7 EPHA7 DYRK1B DYRK1B STYK1 STYK1 SRC SRC EFNA4 EFNA4 JAK1 JAK1 EPHB3 EPHB3 CLK1 CLK1 MUSK MUSK CLK3 CLK3 NTRK1 NTRK1 HTR2A HTR2A CAMKK2 CAMKK2 TIE1 TIE1 SYK SYK RSRC2 RSRC2 IL12RB2 IL12RB2 ENSCCAP00000003376 ENSCCAP00000003376 TXK TXK FLT4 FLT4 IL21 IL21 BTK BTK IGF2R IGF2R PRKCD PRKCD EPHA2 EPHA2 SPINK1 SPINK1 RET RET PTPN6 PTPN6
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
SRMSTyrosine-protein kinase. (486 aa)
RELNReelin. (3278 aa)
CLK2CDC like kinase 2. (539 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (527 aa)
EPHB2EPH receptor B2. (1103 aa)
EPHA4EPH receptor A4. (949 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (927 aa)
HPXHemopexin. (414 aa)
YES1Tyrosine-protein kinase. (441 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
BMXTyrosine-protein kinase. (675 aa)
DYRK3Dual specificity tyrosine phosphorylation regulated kinase 3. (588 aa)
ITKTyrosine-protein kinase. (620 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
EPHA8EPH receptor A8. (1006 aa)
CHKACholine kinase alpha. (453 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (821 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
EPHA1EPH receptor A1. (976 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
MAP3K9Mitogen-activated protein kinase kinase kinase 9. (1105 aa)
PTK6Tyrosine-protein kinase. (451 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
CD3ECD3e molecule. (198 aa)
ENSCCAP00000034027Tyrosine-protein kinase. (360 aa)
HIPK2Homeodomain interacting protein kinase 2. (1189 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
CRIM1Cysteine rich transmembrane BMP regulator 1. (1037 aa)
TECTyrosine-protein kinase. (631 aa)
TTNUncharacterized protein. (27115 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1352 aa)
ROS1Tyrosine-protein kinase receptor. (2347 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (961 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
ALKTyrosine-protein kinase receptor. (1621 aa)
TYRO3TYRO3 protein tyrosine kinase. (890 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
WEE2Wee1-like protein kinase. (564 aa)
TEKTEK receptor tyrosine kinase. (1069 aa)
TESK1Testis associated actin remodelling kinase 1. (626 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (493 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
FGFRL1Fibroblast growth factor receptor like 1. (504 aa)
HIPK3Homeodomain interacting protein kinase 3. (1216 aa)
JAK3Tyrosine-protein kinase. (1115 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
MAP2K4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (410 aa)
EPHA6EPH receptor A6. (1130 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1108 aa)
CD4CD4 molecule. (457 aa)
TNK2Tyrosine kinase non receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1085 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1404 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (766 aa)
EPHA10EPH receptor A10. (1014 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
TTKTTK protein kinase. (856 aa)
LRRK1Leucine rich repeat kinase 1. (2014 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
IGF1RTyrosine-protein kinase receptor. (1285 aa)
ENSCCAP00000025361Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (463 aa)
LCKTyrosine-protein kinase. (515 aa)
TTBK1Tau tubulin kinase 1. (1322 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
DYRK4Dual specificity tyrosine phosphorylation regulated kinase 4; Belongs to the protein kinase superfamily. (480 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1299 aa)
DSTYKDual serine/threonine and tyrosine protein kinase. (929 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (622 aa)
LTKTyrosine-protein kinase receptor. (863 aa)
WEE1Wee1-like protein kinase. (553 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
MST1RMacrophage stimulating 1 receptor. (1400 aa)
EPHB6EPH receptor B6. (1021 aa)
FGFR2Fibroblast growth factor receptor. (782 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
BAZ1BBromodomain adjacent to zinc finger domain 1B. (1372 aa)
FYNTyrosine-protein kinase. (537 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (943 aa)
RPS6KA5Ribosomal protein S6 kinase. (800 aa)
BAZ1ABromodomain adjacent to zinc finger domain 1A. (1363 aa)
EPHB4EPH receptor B4. (987 aa)
ABI2Abl interactor 2. (507 aa)
MATKTyrosine-protein kinase. (507 aa)
TNK1Tyrosine kinase non receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (666 aa)
CLK4CDC like kinase 4; Belongs to the protein kinase superfamily. (481 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (916 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (340 aa)
ABI1Abl interactor 1. (508 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (847 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (990 aa)
EFEMP1EGF containing fibulin extracellular matrix protein 1. (493 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (268 aa)
MERTKReceptor protein-tyrosine kinase. (940 aa)
EPHA5EPH receptor A5. (1038 aa)
FGRTyrosine-protein kinase. (529 aa)
SCYL1SCY1 like pseudokinase 1. (910 aa)
RYKReceptor like tyrosine kinase. (613 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (392 aa)
PBKPDZ binding kinase. (323 aa)
MELKNon-specific serine/threonine protein kinase. (648 aa)
LYNTyrosine-protein kinase. (491 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (925 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
FGFR4Fibroblast growth factor receptor 4. (698 aa)
FGFR1Fibroblast growth factor receptor. (827 aa)
BLKTyrosine-protein kinase. (500 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (757 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
PDGFRLPlatelet derived growth factor receptor like. (375 aa)
PEAK1Pseudopodium enriched atypical kinase 1. (1747 aa)
AATKApoptosis associated tyrosine kinase. (1358 aa)
BCRBCR activator of RhoGEF and GTPase. (1223 aa)
ABL2Tyrosine-protein kinase. (1182 aa)
AXLAXL receptor tyrosine kinase. (896 aa)
FRKTyrosine-protein kinase. (505 aa)
EPHB1EPH receptor B1. (984 aa)
CNTFCiliary neurotrophic factor. (200 aa)
CSKTyrosine-protein kinase. (449 aa)
HIPK1Homeodomain interacting protein kinase 1. (1210 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
LOC108282680Protein kinase domain-containing protein. (245 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (763 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (952 aa)
STK16Serine/threonine kinase 16. (305 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
EPHA3-2Eph LBD domain-containing protein. (286 aa)
EPHA3Uncharacterized protein. (794 aa)
TYK2Tyrosine-protein kinase. (1158 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (152 aa)
INSRTyrosine-protein kinase receptor. (1352 aa)
PTPN4Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (926 aa)
JAK2Tyrosine-protein kinase. (1136 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (962 aa)
ENSCCAP00000009738Uncharacterized protein. (81 aa)
EPHA7EPH receptor A7. (998 aa)
DYRK1BDual specificity tyrosine phosphorylation regulated kinase 1B. (629 aa)
STYK1Serine/threonine/tyrosine kinase 1. (426 aa)
SRCTyrosine-protein kinase. (542 aa)
EFNA4Ephrin A4; Belongs to the ephrin family. (201 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
EPHB3EPH receptor B3. (1001 aa)
CLK1CDC like kinase 1. (517 aa)
MUSKMuscle associated receptor tyrosine kinase. (871 aa)
CLK3CDC like kinase 3. (638 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (588 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
RSRC2Arginine and serine rich coiled-coil 2. (435 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (860 aa)
ENSCCAP00000003376Protein kinase domain-containing protein. (184 aa)
TXKTyrosine-protein kinase. (527 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
BTKTyrosine-protein kinase. (598 aa)
IGF2RInsulin like growth factor 2 receptor. (2492 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
EPHA2EPH receptor A2. (976 aa)
SPINK1Serine peptidase inhibitor, Kazal type 1. (79 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1113 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (608 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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