STRINGSTRING
EPHA2 EPHA2 NFIB NFIB SOX9 SOX9 SOSTDC1 SOSTDC1 TWSG1 TWSG1 LOC108289748 LOC108289748 CEBPB CEBPB NOG NOG BCL2 BCL2 ARG1 ARG1 STAT6 STAT6 TBX3 TBX3 PTCH1 PTCH1 LAMA5 LAMA5 MMP2 MMP2 SRC SRC BMP7 BMP7 TGFBR2 TGFBR2 FEM1B FEM1B AR AR SEMA3C SEMA3C WNT4 WNT4 EDAR EDAR MED1 MED1 IL6 IL6 ENSCCAP00000012370 ENSCCAP00000012370 LRRC1 LRRC1 NRG3 NRG3 TGFB3 TGFB3 LAMA1 LAMA1 CSMD2 CSMD2 PML PML PLXNA1 PLXNA1 ID4 ID4 ESRP2 ESRP2 ELF3 ELF3 WNT5A WNT5A PLXND1 PLXND1 TP63 TP63 PGR PGR TGFB2 TGFB2 CUL3 CUL3 PAX6 PAX6 DDR1 DDR1 CSMD1 CSMD1 TNF TNF RARG RARG CSF1 CSF1 BSX BSX HOXA13 HOXA13 FGF8 FGF8 CYP7B1 CYP7B1 NKX2-3 NKX2-3 BTRC BTRC FGFR2 FGFR2 NKX3-1 NKX3-1 MSN MSN KDM5B KDM5B MST1 MST1 GLI3 GLI3 SERPINB5 SERPINB5 SFRP1 SFRP1 FGF10 FGF10 CRIP1 CRIP1 NTN1 NTN1 ESR1 ESR1 TGFB1 TGFB1 TGM2 TGM2 TGFA TGFA SELENOH SELENOH EDA EDA HOXD13 HOXD13 SCRIB SCRIB NFKB1 NFKB1 MKI67 MKI67 DAG1 DAG1 CSF1R CSF1R SHH SHH NOTCH1 NOTCH1 DUOX2 DUOX2 PROX1 PROX1 POLB POLB GDF7 GDF7 IGFBP5 IGFBP5 LRP5 LRP5 TBX2 TBX2 FGL1 FGL1 BMP4 BMP4 HOXB13 HOXB13 AREG AREG FOXA1 FOXA1 RPS6KA1 RPS6KA1 LOC108289749 LOC108289749 VDR VDR ENSCCAP00000039426 ENSCCAP00000039426 NRP1 NRP1 FGF7 FGF7 PLAG1 PLAG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EPHA2EPH receptor A2. (976 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
SOX9SRY-box transcription factor 9. (509 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
LOC108289748IRS-type PTB domain-containing protein. (526 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
BCL2BCL2 apoptosis regulator. (240 aa)
ARG1Arginase. (322 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
TBX3T-box transcription factor 3. (743 aa)
PTCH1Patched 1. (1452 aa)
LAMA5Laminin subunit alpha 5. (3636 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
SRCTyrosine-protein kinase. (542 aa)
BMP7Bone morphogenetic protein 7. (430 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
FEM1BFem-1 homolog B. (627 aa)
ARAndrogen receptor. (887 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
EDAREctodysplasin A receptor. (448 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa)
IL6Interleukin 6. (212 aa)
ENSCCAP00000012370ANK_REP_REGION domain-containing protein. (518 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
NRG3Neuregulin 3. (719 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LAMA1Laminin subunit alpha 1. (3080 aa)
CSMD2CUB and Sushi multiple domains 2. (3631 aa)
PMLPromyelocytic leukemia. (880 aa)
PLXNA1Plexin A1. (1904 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
ESRP2Epithelial splicing regulatory protein 2. (715 aa)
ELF3E74 like ETS transcription factor 3. (371 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PLXND1Plexin D1. (1924 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
PGRProgesterone receptor. (935 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
PAX6Paired box 6. (447 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (916 aa)
CSMD1CUB and Sushi multiple domains 1. (3564 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
RARGRetinoic acid receptor gamma. (456 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (551 aa)
BSXBrain specific homeobox. (232 aa)
HOXA13Homeobox A13. (385 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (505 aa)
NKX2-3NK2 homeobox 3. (363 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (600 aa)
FGFR2Fibroblast growth factor receptor. (782 aa)
NKX3-1NK3 homeobox 1. (223 aa)
MSNMoesin. (479 aa)
KDM5BLysine demethylase 5B. (1516 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
GLI3GLI family zinc finger 3. (1577 aa)
SERPINB5Serpin family B member 5; Belongs to the serpin family. (375 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
CRIP1LIM zinc-binding domain-containing protein. (77 aa)
NTN1Netrin 1. (604 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (314 aa)
TGM2Transglutaminase 2. (687 aa)
TGFATransforming growth factor alpha. (165 aa)
SELENOHSelenoprotein H. (121 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (389 aa)
HOXD13Homeobox D13. (345 aa)
SCRIBScribble planar cell polarity protein. (1655 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
MKI67Marker of proliferation Ki-67. (3258 aa)
DAG1Dystroglycan 1. (895 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (961 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (464 aa)
NOTCH1Notch receptor 1. (2550 aa)
DUOX2Dual oxidase 2. (1546 aa)
PROX1Prospero homeobox 1. (737 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
GDF7Growth differentiation factor 7. (455 aa)
IGFBP5Insulin like growth factor binding protein 5. (273 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1603 aa)
TBX2T-box transcription factor 2. (713 aa)
FGL1Fibrinogen like 1. (312 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
HOXB13Homeobox B13. (284 aa)
AREGAmphiregulin. (275 aa)
FOXA1Forkhead box A1. (470 aa)
RPS6KA1Ribosomal protein S6 kinase. (729 aa)
LOC108289749Fibroblast growth factor receptor substrate 2. (508 aa)
VDRVitamin D receptor. (427 aa)
ENSCCAP00000039426Uncharacterized protein. (462 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (927 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PLAG1PLAG1 zinc finger. (500 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.