STRINGSTRING
PTPN2 PTPN2 IL6 IL6 LOC108305632 LOC108305632 LEF1 LEF1 BCL3 BCL3 TESPA1 TESPA1 RORC RORC WNT4 WNT4 IKZF3 IKZF3 CCR6 CCR6 TOX TOX IRF4 IRF4 PKNOX1 PKNOX1 ENSCCAP00000010320 ENSCCAP00000010320 ENSCCAP00000009774 ENSCCAP00000009774 BCL11B BCL11B ATG5 ATG5 JMJD6 JMJD6 IL18R1 IL18R1 CLEC4G CLEC4G CTSL CTSL PIK3CD PIK3CD CD8A CD8A STAT6 STAT6 XRCC4 XRCC4 ZBTB7B ZBTB7B JAG2 JAG2 PREX1 PREX1 BCL2 BCL2 ENSCCAP00000005127 ENSCCAP00000005127 RAG1 RAG1 LOC108282470 LOC108282470 LIG4 LIG4 NHEJ1 NHEJ1 CRACR2A CRACR2A RHOH RHOH SYK SYK GPR18 GPR18 PGBD4 PGBD4 ARMC5 ARMC5 FZD8 FZD8 ATP7A ATP7A FADD FADD ITPKB ITPKB THEMIS THEMIS CD3D CD3D FOXP3 FOXP3 STK11 STK11 NCAPH2 NCAPH2 LOC108294221 LOC108294221 NRARP NRARP IL21 IL21 PPP3CB PPP3CB FZD5 FZD5 IL2RG IL2RG LOC108304333 LOC108304333 ZFP36L1 ZFP36L1 GATA3 GATA3 RAG2 RAG2 RUNX2 RUNX2 RC3H2 RC3H2 PIK3R3 PIK3R3 RIPK3 RIPK3 ABL1 ABL1 ENSCCAP00000013066 ENSCCAP00000013066 SP3 SP3 CCR7 CCR7 CARD11 CARD11 TMEM98 TMEM98 PAX1 PAX1 RC3H1 RC3H1 CTNNB1 CTNNB1 CHD7 CHD7 ENSCCAP00000016355 ENSCCAP00000016355 CD74 CD74 RELB RELB TBX21 TBX21 CCR9 CCR9 TCF7 TCF7 BCL6 BCL6 TRAF3IP2 TRAF3IP2 RORA RORA DLL4 DLL4 STAT3 STAT3 LFNG LFNG DNAJA3 DNAJA3 ZFP36L2 ZFP36L2 ENSCCAP00000019119 ENSCCAP00000019119 B2M B2M GIMAP1 GIMAP1 TSC1 TSC1 MTOR MTOR EOMES EOMES NKX2-3 NKX2-3 PRKDC PRKDC PATZ1 PATZ1 ZAP70 ZAP70 LEPR LEPR GPR89B GPR89B ENSCCAP00000023514 ENSCCAP00000023514 SLAMF6 SLAMF6 PTPRC PTPRC GLI3 GLI3 SOX13 SOX13 ZBTB1 ZBTB1 ANXA1 ANXA1 TCIRG1 TCIRG1 LCK LCK PTPN22 PTPN22 ADA ADA CLEC4D CLEC4D FUT7 FUT7 RIPK2 RIPK2 FOXN1 FOXN1 TGFB1 TGFB1 WNT1 WNT1 PLA2G2D PLA2G2D RPS6 RPS6 BRAF BRAF IL7R IL7R CD4 CD4 ENTPD7 ENTPD7 MR1 MR1 SOX4 SOX4 LEP LEP LOC108284022 LOC108284022 CD83 CD83 RSAD2 RSAD2 FOXP1 FOXP1 TP53 TP53 SEMA4A SEMA4A IL7 IL7 ERBB2 ERBB2 CDK6 CDK6 IL4R IL4R AIRE AIRE CLEC4E CLEC4E VAV1 VAV1 KIT KIT IL12B IL12B TNFSF8 TNFSF8 SHH SHH LMBR1L LMBR1L IL15 IL15 PRR7 PRR7 CD3E CD3E STAT5B STAT5B ADAM17 ADAM17 CD28 CD28 IL6R IL6R ATF2 ATF2 PTGER4 PTGER4 LOC108297993 LOC108297993 ZFPM1 ZFPM1 HLX HLX LY9 LY9 PIK3R2 PIK3R2 ITK ITK SASH3 SASH3 IRF1 IRF1 KDELR1 KDELR1 DOCK2 DOCK2 WNT10B WNT10B BATF BATF EGR1 EGR1 SRF SRF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPN2Tyrosine-protein phosphatase non-receptor type. (410 aa)
IL6Interleukin 6. (212 aa)
LOC108305632V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (174 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
BCL3BCL3 transcription coactivator. (454 aa)
TESPA1Thymocyte expressed, positive selection associated 1. (522 aa)
RORCRAR related orphan receptor C. (522 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
IKZF3IKAROS family zinc finger 3. (509 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (377 aa)
TOXThymocyte selection associated high mobility group box. (526 aa)
IRF4Interferon regulatory factor 4. (451 aa)
PKNOX1PBX/knotted 1 homeobox 1. (436 aa)
ENSCCAP00000010320Uncharacterized protein. (666 aa)
ENSCCAP00000009774Uncharacterized protein. (758 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (467 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (414 aa)
IL18R1Interleukin 18 receptor 1. (539 aa)
CLEC4GC-type lectin domain family 4 member G. (290 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1056 aa)
CD8ACD8a molecule. (235 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
XRCC4X-ray repair cross complementing 4. (334 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (573 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1274 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1651 aa)
BCL2BCL2 apoptosis regulator. (240 aa)
ENSCCAP00000005127A_deaminase domain-containing protein. (260 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
LOC10828247040S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
LIG4DNA ligase. (911 aa)
NHEJ1Non-homologous end joining factor 1. (299 aa)
CRACR2ACalcium release activated channel regulator 2A. (731 aa)
RHOHRas homolog family member H. (191 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
GPR18G protein-coupled receptor 18; Belongs to the G-protein coupled receptor 1 family. (331 aa)
PGBD4PiggyBac transposable element derived 4. (585 aa)
ARMC5Armadillo repeat containing 5. (1028 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (687 aa)
ATP7AATPase copper transporting alpha. (1476 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (946 aa)
THEMISThymocyte selection associated. (680 aa)
CD3DCD3d molecule. (171 aa)
FOXP3Forkhead box P3. (454 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
NCAPH2Non-SMC condensin II complex subunit H2. (570 aa)
LOC10829422140S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (216 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
PPP3CBSerine/threonine-protein phosphatase. (533 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
IL2RGFibronectin type-III domain-containing protein. (319 aa)
LOC10830433340S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
GATA3GATA binding protein 3. (444 aa)
RAG2Recombination activating 2. (527 aa)
RUNX2RUNX family transcription factor 2. (540 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
PIK3R3Uncharacterized protein. (577 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (513 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
ENSCCAP00000013066Uncharacterized protein. (96 aa)
SP3Uncharacterized protein. (780 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
CARD11Caspase recruitment domain family member 11. (1156 aa)
TMEM98Transmembrane protein 98. (226 aa)
PAX1Paired box 1. (513 aa)
RC3H1Ring finger and CCCH-type domains 1. (1120 aa)
CTNNB1Catenin beta 1. (781 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2996 aa)
ENSCCAP00000016355Uncharacterized protein. (128 aa)
CD74CD74 molecule. (308 aa)
RELBRELB proto-oncogene, NF-kB subunit. (478 aa)
TBX21T-box transcription factor 21. (535 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
TCF7Transcription factor 7. (482 aa)
BCL6BCL6 transcription repressor. (706 aa)
TRAF3IP2TRAF3 interacting protein 2. (558 aa)
RORARAR related orphan receptor A. (489 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
LFNGBeta-1,3-N-acetylglucosaminyltransferase. (381 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
ZFP36L2ZFP36 ring finger protein like 2. (493 aa)
ENSCCAP00000019119Uncharacterized protein. (129 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
GIMAP1AIG1-type G domain-containing protein. (306 aa)
TSC1TSC complex subunit 1. (1149 aa)
MTORSerine/threonine-protein kinase mTOR. (2508 aa)
EOMESEomesodermin. (705 aa)
NKX2-3NK2 homeobox 3. (363 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4130 aa)
PATZ1POZ/BTB and AT hook containing zinc finger 1. (687 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
LEPRLeptin receptor. (1165 aa)
GPR89BUncharacterized protein. (455 aa)
ENSCCAP00000023514Uncharacterized protein. (89 aa)
SLAMF6SLAM family member 6. (352 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1299 aa)
GLI3GLI family zinc finger 3. (1577 aa)
SOX13SRY-box transcription factor 13. (615 aa)
ZBTB1Zinc finger and BTB domain containing 1. (661 aa)
ANXA1Annexin. (346 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (829 aa)
LCKTyrosine-protein kinase. (515 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (770 aa)
ADAA_deaminase domain-containing protein. (363 aa)
CLEC4DC-type lectin domain family 4 member D. (215 aa)
FUT7Fucosyltransferase 7. (342 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
FOXN1Forkhead box N1. (645 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (314 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
PLA2G2DPhospholipase A(2). (146 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (766 aa)
IL7RInterleukin 7 receptor. (459 aa)
CD4CD4 molecule. (457 aa)
ENTPD7Ectonucleoside triphosphate diphosphohydrolase 7; Belongs to the GDA1/CD39 NTPase family. (605 aa)
MR1Major histocompatibility complex, class I-related; Belongs to the MHC class I family. (340 aa)
SOX4Transcription factor SOX. (470 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
LOC108284022Uncharacterized protein. (199 aa)
CD83CD83 molecule. (201 aa)
RSAD2Radical S-adenosyl methionine domain containing 2. (361 aa)
FOXP1Forkhead box P1. (693 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (395 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (661 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (177 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
IL4RInterleukin 4 receptor. (850 aa)
AIREAutoimmune regulator. (505 aa)
CLEC4EC-type lectin domain family 4 member E. (212 aa)
VAV1Uncharacterized protein. (899 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
TNFSF8TNF superfamily member 8; Belongs to the tumor necrosis factor family. (234 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (464 aa)
LMBR1LLimb development membrane protein 1 like; Belongs to the LIMR family. (548 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
PRR7Proline rich 7, synaptic. (274 aa)
CD3ECD3e molecule. (198 aa)
STAT5BSignal transducer and activator of transcription. (788 aa)
ADAM17ADAM metallopeptidase domain 17. (914 aa)
CD28CD28 molecule. (220 aa)
IL6RInterleukin 6 receptor. (468 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (490 aa)
LOC108297993AIG1-type G domain-containing protein. (303 aa)
ZFPM1Zinc finger protein, FOG family member 1. (1001 aa)
HLXH2.0 like homeobox. (492 aa)
LY9Lymphocyte antigen 9. (657 aa)
PIK3R2Uncharacterized protein. (727 aa)
ITKTyrosine-protein kinase. (620 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
IRF1Interferon regulatory factor. (325 aa)
KDELR1ER lumen protein-retaining receptor. (212 aa)
DOCK2Dedicator of cytokinesis 2; Belongs to the DOCK family. (1830 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
SRFSerum response factor. (509 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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