(88 nodes) Negative regulation of transforming growth factor beta receptor signaling pathway network (Cebus capucinus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	ONECUT2	One cut domain family member. (504 aa)
	SPRY1	Sprouty RTK signaling antagonist 1. (319 aa)
	SAP30L	SAP30 like. (182 aa)
	HTRA4	HtrA serine peptidase 4. (448 aa)
	LINGO3	Leucine rich repeat and Ig domain containing 3. (592 aa)
	SAP30	Sin3A associated protein 30. (220 aa)
	LDLRAD4	Low density lipoprotein receptor class A domain containing 4. (306 aa)
	BMP2	Bone morphogenetic protein 2. (396 aa)
	DAND5	DAN domain BMP antagonist family member 5. (193 aa)
	EID2	EP300 interacting inhibitor of differentiation 2. (228 aa)
	LEMD3	LEM domain containing 3. (911 aa)
	SKOR2	SKI family transcriptional corepressor 2. (1012 aa)
	SAP130	SAP130_C domain-containing protein. (1083 aa)
	ARID4B	AT-rich interaction domain 4B. (1314 aa)
	MTMR4	Myotubularin related protein 4. (1193 aa)
	ADAMTSL2	ADAMTS like 2. (1058 aa)
	ENSCCAP00000009704	Glyco_transf_41 domain-containing protein. (100 aa)
	STUB1	STIP1 homology and U-box containing protein 1. (311 aa)
	SNX25	Sorting nexin 25. (840 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
	TGFB1I1	Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (461 aa)
	PPM1A	Protein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
	PRDM16	PR/SET domain 16. (1277 aa)
	VEPH1	Ventricular zone expressed PH domain containing 1. (833 aa)
	TET1	Tet methylcytosine dioxygenase 1. (1497 aa)
	GLG1	Golgi glycoprotein 1. (1224 aa)
	LOC108318243	Uncharacterized protein. (502 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (554 aa)
	SLC2A10	Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (539 aa)
	CHST11	Carbohydrate sulfotransferase. (352 aa)
	ASPN	Asporin. (374 aa)
	ENG	Endoglin. (655 aa)
	SMURF2	E3 ubiquitin-protein ligase. (735 aa)
	LOC108314072	SAP130_C domain-containing protein. (906 aa)
	FBN1	Fibrillin 1. (2872 aa)
	SMAD6	Mothers against decapentaplegic homolog. (489 aa)
	OGT	TPR_REGION domain-containing protein. (1046 aa)
	SIN3A	SIN3 transcription regulator family member A. (1273 aa)
	NRROS	Negative regulator of reactive oxygen species. (692 aa)
	WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (579 aa)
	PMEPA1	Prostate transmembrane protein, androgen induced 1. (287 aa)
	CD109	CD109 molecule. (1445 aa)
	PBLD	Phenazine biosynthesis like protein domain containing. (288 aa)
	ENSCCAP00000020235	WD_REPEATS_REGION domain-containing protein. (284 aa)
	SKI	SKI proto-oncogene. (729 aa)
	LTBP1	Latent transforming growth factor beta binding protein 1. (1719 aa)
	HTRA1	HtrA serine peptidase 1. (483 aa)
	DNM2	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
	XBP1	BZIP domain-containing protein. (375 aa)
	HSPA5	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
	TGFBR3	Transforming growth factor beta receptor 3. (851 aa)
	SIRT1	Sirtuin 1. (446 aa)
	ENSCCAP00000024245	Peptidyl-prolyl cis-trans isomerase. (141 aa)
	SKIL	SKI like proto-oncogene. (684 aa)
	SPINT3	Serine peptidase inhibitor, Kunitz type 3. (89 aa)
	SPRED3	Sprouty related EVH1 domain containing 3. (457 aa)
	FBN2	Fibrillin 2. (2912 aa)
	ZBTB7A	Zinc finger and BTB domain containing 7A. (584 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (444 aa)
	FAM89B	Family with sequence similarity 89 member B. (153 aa)
	ZNF451	Zinc finger protein 451. (1061 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (315 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
	ING1	Inhibitor of growth protein. (387 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (395 aa)
	CIDEA	Cell death inducing DFFA like effector a. (219 aa)
	SMAD7	Mothers against decapentaplegic homolog. (480 aa)
	BRMS1L	BRMS1 like transcriptional repressor. (323 aa)
	STRAP	Serine/threonine kinase receptor associated protein. (348 aa)
	ADAM17	ADAM metallopeptidase domain 17. (914 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (163 aa)
	IL17RD	Interleukin 17 receptor D. (739 aa)
	ENSCCAP00000035444	Uncharacterized protein. (296 aa)
	SPRED2	Sprouty related EVH1 domain containing 2. (432 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	ING2	Inhibitor of growth protein. (279 aa)
	BCL9L	BCL9 like. (1497 aa)
	NKX2-1	NK2 homeobox 1. (402 aa)
	HTRA3	HtrA serine peptidase 3. (453 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (562 aa)
	EMILIN1	Elastin microfibril interfacer 1. (1016 aa)
	RASL11B	RAS like family 11 member B. (248 aa)
	BRMS1	BRMS1 transcriptional repressor and anoikis regulator. (284 aa)
	SMURF1	E3 ubiquitin-protein ligase. (757 aa)

Your Current Organism:

Cebus capucinus

NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTSL2	FBN1	ENSCCAP00000008209	ENSCCAP00000017454	ADAMTS like 2.	Fibrillin 1.	0.593
ADAMTSL2	FBN2	ENSCCAP00000008209	ENSCCAP00000025946	ADAMTS like 2.	Fibrillin 2.	0.520
ADAMTSL2	LTBP1	ENSCCAP00000008209	ENSCCAP00000020990	ADAMTS like 2.	Latent transforming growth factor beta binding protein 1.	0.584
ARID4B	BRMS1	ENSCCAP00000007681	ENSCCAP00000040179	AT-rich interaction domain 4B.	BRMS1 transcriptional repressor and anoikis regulator.	0.977
ARID4B	BRMS1L	ENSCCAP00000007681	ENSCCAP00000033287	AT-rich interaction domain 4B.	BRMS1 like transcriptional repressor.	0.974
ARID4B	ENSCCAP00000035444	ENSCCAP00000007681	ENSCCAP00000035444	AT-rich interaction domain 4B.	Uncharacterized protein.	0.974
ARID4B	HDAC2	ENSCCAP00000007681	ENSCCAP00000035632	AT-rich interaction domain 4B.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.963
ARID4B	ING1	ENSCCAP00000007681	ENSCCAP00000028180	AT-rich interaction domain 4B.	Inhibitor of growth protein.	0.835
ARID4B	ING2	ENSCCAP00000007681	ENSCCAP00000035770	AT-rich interaction domain 4B.	Inhibitor of growth protein.	0.784
ARID4B	LOC108314072	ENSCCAP00000007681	ENSCCAP00000017338	AT-rich interaction domain 4B.	SAP130_C domain-containing protein.	0.783
ARID4B	SAP130	ENSCCAP00000007681	ENSCCAP00000007206	AT-rich interaction domain 4B.	SAP130_C domain-containing protein.	0.783
ARID4B	SAP30	ENSCCAP00000007681	ENSCCAP00000002400	AT-rich interaction domain 4B.	Sin3A associated protein 30.	0.984
ARID4B	SAP30L	ENSCCAP00000007681	ENSCCAP00000000976	AT-rich interaction domain 4B.	SAP30 like.	0.973
ARID4B	SIN3A	ENSCCAP00000007681	ENSCCAP00000018432	AT-rich interaction domain 4B.	SIN3 transcription regulator family member A.	0.948
ARID4B	TET1	ENSCCAP00000007681	ENSCCAP00000012639	AT-rich interaction domain 4B.	Tet methylcytosine dioxygenase 1.	0.485
BAMBI	SMAD6	ENSCCAP00000023084	ENSCCAP00000018165	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.744
BAMBI	SMAD7	ENSCCAP00000023084	ENSCCAP00000030935	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.837
BMP2	DAND5	ENSCCAP00000003018	ENSCCAP00000003608	Bone morphogenetic protein 2.	DAN domain BMP antagonist family member 5.	0.411
BMP2	EMILIN1	ENSCCAP00000003018	ENSCCAP00000039030	Bone morphogenetic protein 2.	Elastin microfibril interfacer 1.	0.413
BMP2	ENG	ENSCCAP00000003018	ENSCCAP00000016206	Bone morphogenetic protein 2.	Endoglin.	0.467