(42 nodes) Negative regulation of epithelial cell differentiation network (Cebus capucinus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	FRZB	Frizzled related protein. (325 aa)
	FOXJ2	Forkhead box J2. (569 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	SOX9	SRY-box transcription factor 9. (509 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
	S1PR3	Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (378 aa)
	REG3A	Regenerating family member 3 alpha. (175 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
	ENSCCAP00000003550	Uncharacterized protein. (291 aa)
	FOXE3	Forkhead box E3. (319 aa)
	SIX2	SIX homeobox 2. (291 aa)
	TBX3	T-box transcription factor 3. (743 aa)
	ID1	Inhibitor of DNA binding 1, HLH protein. (151 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	GRHL2	Grainyhead like transcription factor 2. (625 aa)
	REG3G	Regenerating family member 3 gamma. (175 aa)
	GDF3	Growth differentiation factor 3. (364 aa)
	NOTCH4	Notch receptor 4. (1993 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	SRSF6	Serine and arginine rich splicing factor 6. (344 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	HES5	Hes family bHLH transcription factor 5. (162 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	ENSCCAP00000021971	Homeobox domain-containing protein. (263 aa)
	OVOL2	Ovo like zinc finger 2. (275 aa)
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	SPRED3	Sprouty related EVH1 domain containing 3. (457 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1124 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (444 aa)
	ACVRL1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
	STAT1	Signal transducer and activator of transcription. (768 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (315 aa)
	NODAL	Nodal growth differentiation factor. (347 aa)
	FST	Follistatin. (344 aa)
	NOTCH1	Notch receptor 1. (2550 aa)
	YAP1	Uncharacterized protein. (506 aa)
	SPRED2	Sprouty related EVH1 domain containing 2. (432 aa)
	LOC108282374	Uncharacterized protein. (330 aa)
	XDH	Xanthine dehydrogenase. (1333 aa)
	MMP9	Matrix metallopeptidase 9. (703 aa)
	SPRY1	Sprouty RTK signaling antagonist 1. (319 aa)

Your Current Organism:

Cebus capucinus

NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVRL1	NODAL	ENSCCAP00000027833	ENSCCAP00000029231	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Nodal growth differentiation factor.	0.467
CCND1	CTNNB1	ENSCCAP00000020912	ENSCCAP00000015925	Cyclin D1; Belongs to the cyclin family.	Catenin beta 1.	0.617
CCND1	JAG1	ENSCCAP00000020912	ENSCCAP00000001030	Cyclin D1; Belongs to the cyclin family.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.407
CCND1	MMP9	ENSCCAP00000020912	ENSCCAP00000038846	Cyclin D1; Belongs to the cyclin family.	Matrix metallopeptidase 9.	0.526
CCND1	NOTCH1	ENSCCAP00000020912	ENSCCAP00000033380	Cyclin D1; Belongs to the cyclin family.	Notch receptor 1.	0.525
CCND1	STAT1	ENSCCAP00000020912	ENSCCAP00000027855	Cyclin D1; Belongs to the cyclin family.	Signal transducer and activator of transcription.	0.439
CTNNB1	CCND1	ENSCCAP00000015925	ENSCCAP00000020912	Catenin beta 1.	Cyclin D1; Belongs to the cyclin family.	0.617
CTNNB1	DLL1	ENSCCAP00000015925	ENSCCAP00000008829	Catenin beta 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.407
CTNNB1	EZH2	ENSCCAP00000015925	ENSCCAP00000003110	Catenin beta 1.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.686
CTNNB1	FRZB	ENSCCAP00000015925	ENSCCAP00000000604	Catenin beta 1.	Frizzled related protein.	0.501
CTNNB1	JAG1	ENSCCAP00000015925	ENSCCAP00000001030	Catenin beta 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.412
CTNNB1	LOC108282374	ENSCCAP00000015925	ENSCCAP00000037676	Catenin beta 1.	Uncharacterized protein.	0.807
CTNNB1	MMP9	ENSCCAP00000015925	ENSCCAP00000038846	Catenin beta 1.	Matrix metallopeptidase 9.	0.475
CTNNB1	NOTCH1	ENSCCAP00000015925	ENSCCAP00000033380	Catenin beta 1.	Notch receptor 1.	0.638
CTNNB1	SMO	ENSCCAP00000015925	ENSCCAP00000002443	Catenin beta 1.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.442
CTNNB1	SOX9	ENSCCAP00000015925	ENSCCAP00000001761	Catenin beta 1.	SRY-box transcription factor 9.	0.770
CTNNB1	YAP1	ENSCCAP00000015925	ENSCCAP00000034056	Catenin beta 1.	Uncharacterized protein.	0.807
CTNNB1	ZEB1	ENSCCAP00000015925	ENSCCAP00000026156	Catenin beta 1.	Zinc finger E-box binding homeobox 1.	0.537
DLL1	CTNNB1	ENSCCAP00000008829	ENSCCAP00000015925	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Catenin beta 1.	0.407
DLL1	HES5	ENSCCAP00000008829	ENSCCAP00000018309	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 5.	0.527