STRINGSTRING
MED1 MED1 IGF2R IGF2R GFER GFER EZH2 EZH2 LOC108294705 LOC108294705 CEBPB CEBPB PGF PGF NNMT NNMT CXCL12 CXCL12 ADM ADM PTCH1 PTCH1 AURKA AURKA CLDN1 CLDN1 TGFBR2 TGFBR2 FLT3 FLT3 LCP1 LCP1 IL6 IL6 SLC7A5 SLC7A5 NR4A3 NR4A3 REG1B REG1B AXL AXL PFKFB1 PFKFB1 CPT1A CPT1A ANGPT2 ANGPT2 GLI1 GLI1 CSNK2A2 CSNK2A2 CCND1 CCND1 SRSF5 SRSF5 TGFBR3 TGFBR3 LPIN1 LPIN1 CPB2 CPB2 LOC108308794 LOC108308794 NR0B2 NR0B2 GAS6 GAS6 TGFB1 TGFB1 WNT1 WNT1 ANXA3 ANXA3 GATA1 GATA1 PTPN3 PTPN3 MKI67 MKI67 BAAT BAAT NOTCH1 NOTCH1 CCNA2 CCNA2 HGF HGF TYMS TYMS UPF2 UPF2 IHH IHH FPGS FPGS BAK1 BAK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa)
IGF2RInsulin like growth factor 2 receptor. (2492 aa)
GFERSulfhydryl oxidase. (201 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
LOC108294705Thymidylat_synt domain-containing protein. (302 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (199 aa)
NNMTNicotinamide N-methyltransferase. (264 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
ADMAdrenomedullin. (184 aa)
PTCH1Patched 1. (1452 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (401 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (962 aa)
LCP1Lymphocyte cytosolic protein 1. (627 aa)
IL6Interleukin 6. (212 aa)
SLC7A5Solute carrier family 7 member 5. (509 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (723 aa)
REG1BRegenerating family member 1 beta. (166 aa)
AXLAXL receptor tyrosine kinase. (896 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (378 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
ANGPT2Angiopoietin 2. (455 aa)
GLI1GLI family zinc finger 1. (1106 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
SRSF5Serine and arginine rich splicing factor 5. (272 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
LPIN1Lipin 1. (974 aa)
CPB2Carboxypeptidase B2. (391 aa)
LOC108308794Uncharacterized protein. (786 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (257 aa)
GAS6Growth arrest specific 6. (676 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (314 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
ANXA3Annexin. (304 aa)
GATA1GATA binding protein 1. (413 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (913 aa)
MKI67Marker of proliferation Ki-67. (3258 aa)
BAATBile acid-CoA:amino acid N-acyltransferase. (418 aa)
NOTCH1Notch receptor 1. (2550 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
TYMSThymidylat_synt domain-containing protein. (313 aa)
UPF2UPF2 regulator of nonsense mediated mRNA decay. (1234 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
FPGSFolylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (568 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.