(28 nodes) Developmental induction network (Cebus capucinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HIPK2	Homeodomain interacting protein kinase 2. (1189 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	LOC108295436	Uncharacterized protein. (281 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	SOX9	SRY-box transcription factor 9. (509 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
	GDNF	Glial cell derived neurotrophic factor. (228 aa)
	BMP2	Bone morphogenetic protein 2. (396 aa)
	LOC108289748	IRS-type PTB domain-containing protein. (526 aa)
	HOXC11	Homeobox C11. (304 aa)
	SPRY1	Sprouty RTK signaling antagonist 1. (319 aa)
	SALL1	Spalt like transcription factor 1. (1309 aa)
	SIX1	SIX homeobox 1. (284 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	SOX8	SRY-box transcription factor 8. (446 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	NKX2-1	NK2 homeobox 1. (402 aa)
	ENSCCAP00000036055	Uncharacterized protein. (232 aa)
	LOC108289749	Fibroblast growth factor receptor substrate 2. (508 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	LOC108290448	Uncharacterized protein. (286 aa)
	HIPK1	Homeodomain interacting protein kinase 1. (1210 aa)
	HOXA11	Homeobox A11. (313 aa)

Your Current Organism:

Cebus capucinus

NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	BMP4	ENSCCAP00000003018	ENSCCAP00000036602	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.960
BMP2	FGF8	ENSCCAP00000003018	ENSCCAP00000021126	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.449
BMP2	SOX9	ENSCCAP00000003018	ENSCCAP00000001761	Bone morphogenetic protein 2.	SRY-box transcription factor 9.	0.403
BMP4	BMP2	ENSCCAP00000036602	ENSCCAP00000003018	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.960
BMP4	FGF1	ENSCCAP00000036602	ENSCCAP00000039927	Bone morphogenetic protein 4.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.418
BMP4	FGF10	ENSCCAP00000036602	ENSCCAP00000025026	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.520
BMP4	FGF8	ENSCCAP00000036602	ENSCCAP00000021126	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.491
BMP4	WNT2	ENSCCAP00000036602	ENSCCAP00000028165	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.416
BMP4	WNT3	ENSCCAP00000036602	ENSCCAP00000023587	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.679
CTNNB1	FGF8	ENSCCAP00000015925	ENSCCAP00000021126	Catenin beta 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.437
CTNNB1	FZD5	ENSCCAP00000015925	ENSCCAP00000001779	Catenin beta 1.	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	0.497
CTNNB1	SOX8	ENSCCAP00000015925	ENSCCAP00000013002	Catenin beta 1.	SRY-box transcription factor 8.	0.608
CTNNB1	SOX9	ENSCCAP00000015925	ENSCCAP00000001761	Catenin beta 1.	SRY-box transcription factor 9.	0.770
CTNNB1	WNT1	ENSCCAP00000015925	ENSCCAP00000026516	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.795
CTNNB1	WNT2	ENSCCAP00000015925	ENSCCAP00000028165	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.644
CTNNB1	WNT2B	ENSCCAP00000015925	ENSCCAP00000025707	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.568
CTNNB1	WNT3	ENSCCAP00000015925	ENSCCAP00000023587	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.627
CTNNB1	WNT4	ENSCCAP00000015925	ENSCCAP00000010926	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.638
FGF1	BMP4	ENSCCAP00000039927	ENSCCAP00000036602	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Bone morphogenetic protein 4.	0.418
FGF1	FGF10	ENSCCAP00000039927	ENSCCAP00000025026	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.555