(47 nodes) Negative regulation of TOR signaling network (Cebus capucinus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	PRKAA2	Non-specific serine/threonine protein kinase. (552 aa)
	GSK3A	Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
	TSC2	TSC complex subunit 2. (1777 aa)
	WDR24	WD repeat domain 24. (913 aa)
	NPRL3	NPR3 like, GATOR1 complex subunit. (582 aa)
	CASTOR2	Uncharacterized protein. (329 aa)
	TMEM127	Transmembrane protein 127. (238 aa)
	UBR1	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1070 aa)
	FLCN	Folliculin. (616 aa)
	ENSCCAP00000030087	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (376 aa)
	SESN2	Sestrin 2. (480 aa)
	CRYBA1	Crystallin beta A1; Belongs to the beta/gamma-crystallin family. (231 aa)
	C12orf66	Chromosome 12 open reading frame 66. (468 aa)
	LOC108293547	Uncharacterized protein. (773 aa)
	ENSCCAP00000027253	Uncharacterized protein. (75 aa)
	SESN3	Sestrin 3. (522 aa)
	CASTOR1	Uncharacterized protein. (329 aa)
	MINAR1	Membrane integral NOTCH2 associated receptor 1. (916 aa)
	DDIT4	DNA damage inducible transcript 4. (232 aa)
	SIRT1	Sirtuin 1. (446 aa)
	SZT2	SZT2 subunit of KICSTOR complex. (3388 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (574 aa)
	HIF1A	Uncharacterized protein. (848 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3000 aa)
	ARNTL	Uncharacterized protein. (629 aa)
	TSC1	TSC complex subunit 1. (1149 aa)
	RNF167	Ring finger protein 167. (352 aa)
	KPTN	Kaptin, actin binding protein. (427 aa)
	WDR59	WD repeat domain 59. (974 aa)
	UBR2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa)
	LOC108317003	Uncharacterized protein. (406 aa)
	ITFG2	Integrin alpha FG-GAP repeat containing 2. (444 aa)
	SEC13	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (368 aa)
	EPM2A	EPM2A glucan phosphatase, laforin. (331 aa)
	TBC1D7	TBC1 domain family member 7. (293 aa)
	SESN1	Sestrin 1. (543 aa)
	MAPKAPK5	MAPK activated protein kinase 5. (473 aa)
	ENSCCAP00000011133	Uncharacterized protein. (517 aa)
	BMT2	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
	DEPTOR	DEP domain containing MTOR interacting protein. (409 aa)
	SH3BP4	SH3 domain binding protein 4. (963 aa)
	AKT1S1	AKT1 substrate 1. (276 aa)
	RNF152	Ring finger protein 152. (203 aa)
	NPRL2	NPR2 like, GATOR1 complex subunit. (383 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
	FNIP1	Folliculin interacting protein 1. (1134 aa)
	TNFAIP8L1	TNF alpha induced protein 8 like 1. (186 aa)

Your Current Organism:

Cebus capucinus

NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1S1	DEPTOR	ENSCCAP00000004175	ENSCCAP00000007921	AKT1 substrate 1.	DEP domain containing MTOR interacting protein.	0.946
AKT1S1	PRKAA1	ENSCCAP00000004175	ENSCCAP00000021862	AKT1 substrate 1.	Non-specific serine/threonine protein kinase.	0.917
AKT1S1	PRKAA2	ENSCCAP00000004175	ENSCCAP00000034805	AKT1 substrate 1.	Non-specific serine/threonine protein kinase.	0.917
AKT1S1	SESN2	ENSCCAP00000004175	ENSCCAP00000029319	AKT1 substrate 1.	Sestrin 2.	0.400
AKT1S1	SESN3	ENSCCAP00000004175	ENSCCAP00000026425	AKT1 substrate 1.	Sestrin 3.	0.400
AKT1S1	TSC1	ENSCCAP00000004175	ENSCCAP00000020798	AKT1 substrate 1.	TSC complex subunit 1.	0.525
AKT1S1	TSC2	ENSCCAP00000004175	ENSCCAP00000038471	AKT1 substrate 1.	TSC complex subunit 2.	0.567
ARNTL	HIF1A	ENSCCAP00000021051	ENSCCAP00000021709	Uncharacterized protein.	Uncharacterized protein.	0.602
ARNTL	LOC108293547	ENSCCAP00000021051	ENSCCAP00000027509	Uncharacterized protein.	Uncharacterized protein.	0.602
ARNTL	SIRT1	ENSCCAP00000021051	ENSCCAP00000023626	Uncharacterized protein.	Sirtuin 1.	0.676
ATM	PRKAA1	ENSCCAP00000021607	ENSCCAP00000021862	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Non-specific serine/threonine protein kinase.	0.558
ATM	SIRT1	ENSCCAP00000021607	ENSCCAP00000023626	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Sirtuin 1.	0.560
ATM	STK11	ENSCCAP00000021607	ENSCCAP00000002521	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine kinase 11; Belongs to the protein kinase superfamily.	0.571
ATM	TSC2	ENSCCAP00000021607	ENSCCAP00000038471	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	TSC complex subunit 2.	0.402
BMT2	C12orf66	ENSCCAP00000009285	ENSCCAP00000028369	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Chromosome 12 open reading frame 66.	0.942
BMT2	CASTOR2	ENSCCAP00000009285	ENSCCAP00000033586	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Uncharacterized protein.	0.457
BMT2	ENSCCAP00000027253	ENSCCAP00000009285	ENSCCAP00000027253	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Uncharacterized protein.	0.653
BMT2	ITFG2	ENSCCAP00000009285	ENSCCAP00000018331	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Integrin alpha FG-GAP repeat containing 2.	0.918
BMT2	KPTN	ENSCCAP00000009285	ENSCCAP00000019821	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Kaptin, actin binding protein.	0.842
BMT2	NPRL2	ENSCCAP00000009285	ENSCCAP00000002645	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	NPR2 like, GATOR1 complex subunit.	0.859