(30 nodes) Activation of protein kinase B activity network (Cebus capucinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCDC88A	Coiled-coil domain containing 88A. (1871 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	OSBPL8	PH domain-containing protein. (846 aa)
	ENSCCAP00000019230	Oxysterol-binding protein; Belongs to the OSBP family. (853 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (605 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	MTOR	Serine/threonine-protein kinase mTOR. (2508 aa)
	MT3	Metallothionein 3; Belongs to the metallothionein superfamily. Type 1 family. (113 aa)
	DYNAP	Dynactin associated protein. (206 aa)
	PINK1	PTEN induced kinase 1. (581 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
	ENSCCAP00000000830	DJ-1_PfpI domain-containing protein. (140 aa)
	GAS6	Growth arrest specific 6. (676 aa)
	ADRA2C	Adrenoceptor alpha 2C. (457 aa)
	NRG1	Neuregulin 1. (713 aa)
	NTRK3	Tyrosine-protein kinase receptor. (864 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	IGF1	Insulin like growth factor 1. (199 aa)
	ENSCCAP00000038186	DJ-1_PfpI domain-containing protein. (132 aa)
	LOC108305208	DJ-1_PfpI domain-containing protein. (149 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (562 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (272 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	PARK7	DJ-1_PfpI domain-containing protein. (189 aa)
	ENSCCAP00000009736	DJ-1_PfpI domain-containing protein. (174 aa)
	INSR	Tyrosine-protein kinase receptor. (1352 aa)
	ENSCCAP00000013848	DJ-1_PfpI domain-containing protein. (153 aa)
	SLC1A1	Amino acid transporter. (524 aa)
	ADRA2A	Adrenoceptor alpha 2A. (466 aa)

Your Current Organism:

Cebus capucinus

NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCCAP00000000830	PINK1	ENSCCAP00000000830	ENSCCAP00000023571	DJ-1_PfpI domain-containing protein.	PTEN induced kinase 1.	0.424
ENSCCAP00000009736	PINK1	ENSCCAP00000009736	ENSCCAP00000023571	DJ-1_PfpI domain-containing protein.	PTEN induced kinase 1.	0.424
ENSCCAP00000013848	PINK1	ENSCCAP00000013848	ENSCCAP00000023571	DJ-1_PfpI domain-containing protein.	PTEN induced kinase 1.	0.424
ENSCCAP00000038186	PINK1	ENSCCAP00000038186	ENSCCAP00000023571	DJ-1_PfpI domain-containing protein.	PTEN induced kinase 1.	0.424
FGF1	IGF1	ENSCCAP00000039927	ENSCCAP00000037209	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Insulin like growth factor 1.	0.535
FGF1	INSR	ENSCCAP00000039927	ENSCCAP00000011036	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Tyrosine-protein kinase receptor.	0.766
FGF1	NTRK3	ENSCCAP00000039927	ENSCCAP00000036151	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Tyrosine-protein kinase receptor.	0.623
IGF1	FGF1	ENSCCAP00000037209	ENSCCAP00000039927	Insulin like growth factor 1.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.535
IGF1	IL18	ENSCCAP00000037209	ENSCCAP00000039638	Insulin like growth factor 1.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.437
IGF1	INSR	ENSCCAP00000037209	ENSCCAP00000011036	Insulin like growth factor 1.	Tyrosine-protein kinase receptor.	0.996
IGF1	MTOR	ENSCCAP00000037209	ENSCCAP00000020925	Insulin like growth factor 1.	Serine/threonine-protein kinase mTOR.	0.402
IGF1	NTRK3	ENSCCAP00000037209	ENSCCAP00000036151	Insulin like growth factor 1.	Tyrosine-protein kinase receptor.	0.734
IGF1	PDGFB	ENSCCAP00000037209	ENSCCAP00000025819	Insulin like growth factor 1.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.966
IGF1	SRC	ENSCCAP00000037209	ENSCCAP00000008680	Insulin like growth factor 1.	Tyrosine-protein kinase.	0.557
IL18	IGF1	ENSCCAP00000039638	ENSCCAP00000037209	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Insulin like growth factor 1.	0.437
INSR	FGF1	ENSCCAP00000011036	ENSCCAP00000039927	Tyrosine-protein kinase receptor.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.766
INSR	IGF1	ENSCCAP00000011036	ENSCCAP00000037209	Tyrosine-protein kinase receptor.	Insulin like growth factor 1.	0.996
INSR	MTOR	ENSCCAP00000011036	ENSCCAP00000020925	Tyrosine-protein kinase receptor.	Serine/threonine-protein kinase mTOR.	0.443
INSR	NTF3	ENSCCAP00000011036	ENSCCAP00000038662	Tyrosine-protein kinase receptor.	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.563
INSR	PDGFB	ENSCCAP00000011036	ENSCCAP00000025819	Tyrosine-protein kinase receptor.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.934