(39 nodes) Response to fluid shear stress network (Cebus capucinus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAPK7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (816 aa)
	HAS2	Hyaluronan synthase 2. (552 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4246 aa)
	ABCA1	ATP binding cassette subfamily A member 1. (2258 aa)
	ENSCCAP00000038024	Uncharacterized protein. (368 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (489 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
	KLF4	Kruppel like factor 4. (477 aa)
	CSF2	Colony stimulating factor 2. (144 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (606 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (984 aa)
	SMAD7	Mothers against decapentaplegic homolog. (480 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1108 aa)
	PLEC	Plectin. (4683 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (314 aa)
	ENSCCAP00000025678	Uncharacterized protein. (389 aa)
	MAP2K5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (604 aa)
	XBP1	BZIP domain-containing protein. (375 aa)
	ENSCCAP00000021762	Uncharacterized protein. (251 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (990 aa)
	SMAD6	Mothers against decapentaplegic homolog. (489 aa)
	KLF2	Kruppel like factor 2. (354 aa)
	TFPI2	Tissue factor pathway inhibitor. (232 aa)
	SREBF2	Sterol regulatory element binding transcription factor 2. (1145 aa)
	MTSS1	MTSS I-BAR domain containing 1. (759 aa)
	ENSCCAP00000013909	Uncharacterized protein. (97 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (275 aa)
	ASS1	Uncharacterized protein. (412 aa)
	LOC108298753	Uncharacterized protein. (242 aa)
	MMP2	Matrix metallopeptidase 2. (660 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	ENSCCAP00000011303	Uncharacterized protein. (104 aa)
	ENSCCAP00000011857	Uncharacterized protein. (151 aa)

Your Current Organism:

Cebus capucinus

NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	SREBF2	ENSCCAP00000040411	ENSCCAP00000015615	ATP binding cassette subfamily A member 1.	Sterol regulatory element binding transcription factor 2.	0.640
AKT1	KLF4	ENSCCAP00000034600	ENSCCAP00000033780	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Kruppel like factor 4.	0.422
AKT1	MMP2	ENSCCAP00000034600	ENSCCAP00000007902	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Matrix metallopeptidase 2.	0.486
AKT1	NFE2L2	ENSCCAP00000034600	ENSCCAP00000031939	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nuclear factor, erythroid 2 like 2.	0.728
AKT1	NOS3	ENSCCAP00000034600	ENSCCAP00000034057	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nitric oxide synthase; Produces nitric oxide (NO).	0.989
AKT1	PDGFRB	ENSCCAP00000034600	ENSCCAP00000027460	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.426
AKT1	SMAD7	ENSCCAP00000034600	ENSCCAP00000030935	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.444
AKT1	SRC	ENSCCAP00000034600	ENSCCAP00000008680	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.799
AKT1	TGFB1	ENSCCAP00000034600	ENSCCAP00000026494	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.541
AKT1	XBP1	ENSCCAP00000034600	ENSCCAP00000022213	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BZIP domain-containing protein.	0.401
ASS1	NOS3	ENSCCAP00000004614	ENSCCAP00000034057	Uncharacterized protein.	Nitric oxide synthase; Produces nitric oxide (NO).	0.781
CSF2	PDGFRB	ENSCCAP00000032934	ENSCCAP00000027460	Colony stimulating factor 2.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.788
ENSCCAP00000011303	ENSCCAP00000021762	ENSCCAP00000011303	ENSCCAP00000021762	Uncharacterized protein.	Uncharacterized protein.	0.673
ENSCCAP00000011303	NOS3	ENSCCAP00000011303	ENSCCAP00000034057	Uncharacterized protein.	Nitric oxide synthase; Produces nitric oxide (NO).	0.781
ENSCCAP00000011857	P2RX4	ENSCCAP00000011857	ENSCCAP00000001836	Uncharacterized protein.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.466
ENSCCAP00000013909	ENSCCAP00000021762	ENSCCAP00000013909	ENSCCAP00000021762	Uncharacterized protein.	Uncharacterized protein.	0.632
ENSCCAP00000013909	NOS3	ENSCCAP00000013909	ENSCCAP00000034057	Uncharacterized protein.	Nitric oxide synthase; Produces nitric oxide (NO).	0.781
ENSCCAP00000021762	ENSCCAP00000011303	ENSCCAP00000021762	ENSCCAP00000011303	Uncharacterized protein.	Uncharacterized protein.	0.673
ENSCCAP00000021762	ENSCCAP00000013909	ENSCCAP00000021762	ENSCCAP00000013909	Uncharacterized protein.	Uncharacterized protein.	0.632
ENSCCAP00000021762	NOS3	ENSCCAP00000021762	ENSCCAP00000034057	Uncharacterized protein.	Nitric oxide synthase; Produces nitric oxide (NO).	0.781