(49 nodes) Somatic stem cell population maintenance network (Cebus capucinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MED28	Uncharacterized protein. (178 aa)
	ENSCCAP00000000953	Uncharacterized protein. (966 aa)
	SOX9	SRY-box transcription factor 9. (509 aa)
	ENSCCAP00000002812	Uncharacterized protein. (154 aa)
	ZHX2	Zinc fingers and homeoboxes 2. (837 aa)
	LIG4	DNA ligase. (911 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	SIX2	SIX homeobox 2. (291 aa)
	REST	RE1 silencing transcription factor. (1100 aa)
	ENSCCAP00000008780	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	GATA2	GATA binding protein 2. (480 aa)
	BCL9	BCL9 transcription coactivator. (1426 aa)
	RIF1	Replication timing regulatory factor 1. (2437 aa)
	HMGA2	Uncharacterized protein. (118 aa)
	CDX2	Caudal type homeobox 2. (311 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	ENSCCAP00000018591	Uncharacterized protein. (164 aa)
	ZFP36L2	ZFP36 ring finger protein like 2. (493 aa)
	LOC108297016	Mediator complex subunit 27. (160 aa)
	SKI	SKI proto-oncogene. (729 aa)
	MED14	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1418 aa)
	SALL4	Uncharacterized protein. (1012 aa)
	SFRP1	Secreted frizzled related protein 1. (314 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (766 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	LIF	LIF interleukin 6 family cytokine. (202 aa)
	SOX4	Transcription factor SOX. (470 aa)
	LDB2	LIM domain binding 2. (373 aa)
	LDB1	LIM domain binding 1. (411 aa)
	MED7	Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (233 aa)
	MED21	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (158 aa)
	NODAL	Nodal growth differentiation factor. (347 aa)
	CUL4A	Cullin 4A; Belongs to the cullin family. (696 aa)
	MED30	Mediator complex subunit 30. (178 aa)
	KLF10	Kruppel like factor 10. (480 aa)
	SMC1A	Structural maintenance of chromosomes protein. (1233 aa)
	MED12	Mediator complex subunit 12. (2200 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (421 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (432 aa)
	KLF4	Kruppel like factor 4. (477 aa)
	YAP1	Uncharacterized protein. (506 aa)
	VPS72	Vacuolar protein sorting 72 homolog. (340 aa)
	BCL9L	BCL9 like. (1497 aa)
	LOC108282374	Uncharacterized protein. (330 aa)
	NIPBL	Nipped-B protein. (2814 aa)
	MED27	Uncharacterized protein. (173 aa)
	MED15	Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (783 aa)

Your Current Organism:

Cebus capucinus

NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL9	BCL9L	ENSCCAP00000013291	ENSCCAP00000036553	BCL9 transcription coactivator.	BCL9 like.	0.428
BCL9L	BCL9	ENSCCAP00000036553	ENSCCAP00000013291	BCL9 like.	BCL9 transcription coactivator.	0.428
BMPR1A	NODAL	ENSCCAP00000033496	ENSCCAP00000029231	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Nodal growth differentiation factor.	0.467
BMPR1A	NOG	ENSCCAP00000033496	ENSCCAP00000005156	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.508
BRAF	STAT3	ENSCCAP00000026774	ENSCCAP00000017914	B-Raf proto-oncogene, serine/threonine kinase.	Signal transducer and activator of transcription.	0.523
BRAF	ZHX2	ENSCCAP00000026774	ENSCCAP00000004001	B-Raf proto-oncogene, serine/threonine kinase.	Zinc fingers and homeoboxes 2.	0.471
CDX2	ENSCCAP00000008780	ENSCCAP00000016013	ENSCCAP00000008780	Caudal type homeobox 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.447
CDX2	FGF4	ENSCCAP00000016013	ENSCCAP00000011610	Caudal type homeobox 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.447
CUL4A	LIG4	ENSCCAP00000030121	ENSCCAP00000004757	Cullin 4A; Belongs to the cullin family.	DNA ligase.	0.512
ENSCCAP00000002812	LOC108297016	ENSCCAP00000002812	ENSCCAP00000020556	Uncharacterized protein.	Mediator complex subunit 27.	0.872
ENSCCAP00000002812	MED12	ENSCCAP00000002812	ENSCCAP00000031541	Uncharacterized protein.	Mediator complex subunit 12.	0.896
ENSCCAP00000002812	MED14	ENSCCAP00000002812	ENSCCAP00000021512	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.903
ENSCCAP00000002812	MED15	ENSCCAP00000002812	ENSCCAP00000038156	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.899
ENSCCAP00000002812	MED21	ENSCCAP00000002812	ENSCCAP00000029024	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.905
ENSCCAP00000002812	MED27	ENSCCAP00000002812	ENSCCAP00000037859	Uncharacterized protein.	Uncharacterized protein.	0.872
ENSCCAP00000002812	MED30	ENSCCAP00000002812	ENSCCAP00000030612	Uncharacterized protein.	Mediator complex subunit 30.	0.912
ENSCCAP00000002812	MED7	ENSCCAP00000002812	ENSCCAP00000028941	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery.	0.903
ENSCCAP00000008780	CDX2	ENSCCAP00000008780	ENSCCAP00000016013	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Caudal type homeobox 2.	0.447
ENSCCAP00000008780	FGF10	ENSCCAP00000008780	ENSCCAP00000025026	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.445
ENSCCAP00000018591	LOC108297016	ENSCCAP00000018591	ENSCCAP00000020556	Uncharacterized protein.	Mediator complex subunit 27.	0.872