(39 nodes) RNA polymerase core enzyme binding network (Cebus capucinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FBF1	Fas binding factor 1. (1147 aa)
	RPRD1A	Regulation of nuclear pre-mRNA domain containing 1A. (312 aa)
	GTF2B	General transcription factor IIB. (316 aa)
	SCAF8	SR-related CTD associated factor 8. (1336 aa)
	RPAP2	RNA polymerase II associated protein 2. (612 aa)
	RPRD1B	Regulation of nuclear pre-mRNA domain containing 1B. (326 aa)
	ENSCCAP00000010913	SPRY domain-containing protein. (494 aa)
	DHX9	DExH-box helicase 9. (1136 aa)
	PCF11	PCF11 cleavage and polyadenylation factor subunit. (1686 aa)
	SMYD3	SET and MYND domain containing 3. (428 aa)
	URI1	URI1 prefoldin like chaperone. (556 aa)
	NCOA3	Nuclear receptor coactivator. (1417 aa)
	LEO1	LEO1 homolog, Paf1/RNA polymerase II complex component. (666 aa)
	PCIF1	PDX1 C-terminal inhibiting factor 1. (704 aa)
	CCAR2	Cell cycle and apoptosis regulator 2. (923 aa)
	MAF1	Repressor of RNA polymerase III transcription MAF1; Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family. (258 aa)
	BRD4	Bromodomain containing 4. (1367 aa)
	WDR43	WD repeat domain 43. (678 aa)
	ZNF326	Zinc finger protein 326; Belongs to the AKAP95 family. (579 aa)
	SMYD2	SET and MYND domain containing 2. (433 aa)
	CDC73	Cell division cycle 73. (531 aa)
	ENSCCAP00000027146	Uncharacterized protein. (482 aa)
	RECQL5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (990 aa)
	PAF1	PAF1 homolog, Paf1/RNA polymerase II complex component. (529 aa)
	RTRAF	RNA transcription, translation and transport factor. (244 aa)
	RPRD2	Regulation of nuclear pre-mRNA domain containing 2. (1460 aa)
	WAC	WW domain containing adaptor with coiled-coil. (663 aa)
	UVSSA	UV stimulated scaffold protein A. (711 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1255 aa)
	ELOF1	Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. (120 aa)
	IWS1	Interacts with SUPT6H, CTD assembly factor 1. (819 aa)
	SCAF4	SR-related CTD associated factor 4. (1145 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (876 aa)
	ENSCCAP00000037060	Uncharacterized protein. (352 aa)
	SPTY2D1	Uncharacterized protein. (663 aa)
	SCAF1	SR-related CTD associated factor 1. (1312 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (825 aa)
	CTR9	CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
	AGO1	Argonaute RISC component 1; Belongs to the argonaute family. (857 aa)

Your Current Organism:

Cebus capucinus

NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO1	AGO2	ENSCCAP00000001918	ENSCCAP00000034652	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.977
AGO1	DHX9	ENSCCAP00000001918	ENSCCAP00000009746	Argonaute RISC component 1; Belongs to the argonaute family.	DExH-box helicase 9.	0.630
AGO2	AGO1	ENSCCAP00000034652	ENSCCAP00000001918	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Argonaute RISC component 1; Belongs to the argonaute family.	0.977
AGO2	CTR9	ENSCCAP00000034652	ENSCCAP00000040474	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	CTR9 homolog, Paf1/RNA polymerase II complex component.	0.543
AGO2	DHX9	ENSCCAP00000034652	ENSCCAP00000009746	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	DExH-box helicase 9.	0.886
BRD4	SMYD2	ENSCCAP00000020659	ENSCCAP00000023535	Bromodomain containing 4.	SET and MYND domain containing 2.	0.528
CCAR2	ZNF326	ENSCCAP00000016609	ENSCCAP00000023369	Cell cycle and apoptosis regulator 2.	Zinc finger protein 326; Belongs to the AKAP95 family.	0.628
CDC73	CTR9	ENSCCAP00000023788	ENSCCAP00000040474	Cell division cycle 73.	CTR9 homolog, Paf1/RNA polymerase II complex component.	0.998
CDC73	ELOF1	ENSCCAP00000023788	ENSCCAP00000031273	Cell division cycle 73.	Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family.	0.859
CDC73	IWS1	ENSCCAP00000023788	ENSCCAP00000031466	Cell division cycle 73.	Interacts with SUPT6H, CTD assembly factor 1.	0.796
CDC73	LEO1	ENSCCAP00000023788	ENSCCAP00000016263	Cell division cycle 73.	LEO1 homolog, Paf1/RNA polymerase II complex component.	0.999
CDC73	PAF1	ENSCCAP00000023788	ENSCCAP00000027766	Cell division cycle 73.	PAF1 homolog, Paf1/RNA polymerase II complex component.	0.998
CDC73	PCF11	ENSCCAP00000023788	ENSCCAP00000007871	Cell division cycle 73.	PCF11 cleavage and polyadenylation factor subunit.	0.401
CDC73	RPAP2	ENSCCAP00000023788	ENSCCAP00000014100	Cell division cycle 73.	RNA polymerase II associated protein 2.	0.445
CDC73	UVSSA	ENSCCAP00000023788	ENSCCAP00000029001	Cell division cycle 73.	UV stimulated scaffold protein A.	0.689
CDC73	WAC	ENSCCAP00000023788	ENSCCAP00000028964	Cell division cycle 73.	WW domain containing adaptor with coiled-coil.	0.653
CTR9	AGO2	ENSCCAP00000040474	ENSCCAP00000034652	CTR9 homolog, Paf1/RNA polymerase II complex component.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.543
CTR9	CDC73	ENSCCAP00000040474	ENSCCAP00000023788	CTR9 homolog, Paf1/RNA polymerase II complex component.	Cell division cycle 73.	0.998
CTR9	DHX9	ENSCCAP00000040474	ENSCCAP00000009746	CTR9 homolog, Paf1/RNA polymerase II complex component.	DExH-box helicase 9.	0.414
CTR9	ELOF1	ENSCCAP00000040474	ENSCCAP00000031273	CTR9 homolog, Paf1/RNA polymerase II complex component.	Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family.	0.802