(45 nodes) Positive regulation of Notch signaling pathway network (Cebus capucinus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NEPRO	Nucleolus and neural progenitor protein. (507 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	IL6ST	Interleukin 6 signal transducer. (919 aa)
	ROBO1	Roundabout guidance receptor 1. (1651 aa)
	ENHO	Energy homeostasis associated. (76 aa)
	GATA5	GATA binding protein 5. (397 aa)
	CNTN6	Contactin 6. (1029 aa)
	ENSCCAP00000003834	Ig-like domain-containing protein. (132 aa)
	TSPAN14	Tetraspanin. (270 aa)
	LOC108297870	Uncharacterized protein. (250 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (233 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1274 aa)
	PDCD10	Programmed cell death 10. (212 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	TSPAN5	Tetraspanin. (268 aa)
	MFNG	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (292 aa)
	GSX2	GS homeobox 2. (305 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (257 aa)
	POGLUT1	Protein O-glucosyltransferase 1. (391 aa)
	AAK1	AP2 associated kinase 1. (964 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	LFNG	Beta-1,3-N-acetylglucosaminyltransferase. (381 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	HES5	Hes family bHLH transcription factor 5. (162 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	ZMIZ1	Zinc finger MIZ-type containing 1. (1072 aa)
	TM2D2	TM2 domain containing 2. (214 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	RFNG	Beta-1,3-N-acetylglucosaminyltransferase. (335 aa)
	CCN3	Cellular communication network factor 3. (357 aa)
	FKBP14	Peptidylprolyl isomerase. (211 aa)
	EPN2	Epsin 2. (641 aa)
	SLC35C2	Solute carrier family 35 member C2. (393 aa)
	TM2D3	TM2 domain containing 3. (247 aa)
	NOTCH1	Notch receptor 1. (2550 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1040 aa)
	YAP1	Uncharacterized protein. (506 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
	BMP2K	BMP2 inducible kinase. (1136 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	LOC108282374	Uncharacterized protein. (330 aa)
	ROBO2	Roundabout guidance receptor 2. (1395 aa)

Your Current Organism:

Cebus capucinus

NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL1	GSX2	ENSCCAP00000005763	ENSCCAP00000012292	Achaete-scute family bHLH transcription factor 1.	GS homeobox 2.	0.649
CCN3	NOTCH1	ENSCCAP00000028297	ENSCCAP00000033380	Cellular communication network factor 3.	Notch receptor 1.	0.418
DLL1	DLL4	ENSCCAP00000008829	ENSCCAP00000017781	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.893
DLL1	HES5	ENSCCAP00000008829	ENSCCAP00000018309	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 5.	0.527
DLL1	JAG1	ENSCCAP00000008829	ENSCCAP00000001030	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.564
DLL1	JAG2	ENSCCAP00000008829	ENSCCAP00000005964	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.418
DLL1	LFNG	ENSCCAP00000008829	ENSCCAP00000017949	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Beta-1,3-N-acetylglucosaminyltransferase.	0.601
DLL1	LOC108297870	ENSCCAP00000008829	ENSCCAP00000005044	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.536
DLL1	MFNG	ENSCCAP00000008829	ENSCCAP00000011146	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase.	0.422
DLL1	NOTCH1	ENSCCAP00000008829	ENSCCAP00000033380	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.985
DLL4	DLL1	ENSCCAP00000017781	ENSCCAP00000008829	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.893
DLL4	JAG1	ENSCCAP00000017781	ENSCCAP00000001030	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.465
DLL4	JAG2	ENSCCAP00000017781	ENSCCAP00000005964	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.568
DLL4	LOC108297870	ENSCCAP00000017781	ENSCCAP00000005044	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.536
DLL4	NOTCH1	ENSCCAP00000017781	ENSCCAP00000033380	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.983
EPN2	TP63	ENSCCAP00000030768	ENSCCAP00000018140	Epsin 2.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.511
FKBP14	POGLUT1	ENSCCAP00000030069	ENSCCAP00000016166	Peptidylprolyl isomerase.	Protein O-glucosyltransferase 1.	0.659
GSX2	ASCL1	ENSCCAP00000012292	ENSCCAP00000005763	GS homeobox 2.	Achaete-scute family bHLH transcription factor 1.	0.649
HES5	DLL1	ENSCCAP00000018309	ENSCCAP00000008829	Hes family bHLH transcription factor 5.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.527
HES5	JAG1	ENSCCAP00000018309	ENSCCAP00000001030	Hes family bHLH transcription factor 5.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.490