(48 nodes) Positive regulation of receptor-mediated endocytosis network (Cebus capucinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SCYL2	SCY1 like pseudokinase 2. (933 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	BICD1	BICD cargo adaptor 1. (975 aa)
	PICK1	Protein interacting with PRKCA 1. (415 aa)
	SYK	Spleen associated tyrosine kinase. (636 aa)
	CLU	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (448 aa)
	RAB21	RAB21, member RAS oncogene family. (216 aa)
	ARRB2	Arrestin beta 2. (409 aa)
	MAGI2	Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1450 aa)
	SYNJ1	Synaptojanin 1. (1529 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	AHI1	Abelson helper integration site 1. (1176 aa)
	ARRB1	Arrestin beta 1. (412 aa)
	FMR1	Fragile X mental retardation 1. (632 aa)
	ANGPT1	Angiopoietin 1. (498 aa)
	ANXA2	Annexin. (357 aa)
	INSR	Tyrosine-protein kinase receptor. (1352 aa)
	HIP1	Huntingtin interacting protein 1. (1003 aa)
	ENSCCAP00000013558	Uncharacterized protein. (296 aa)
	SGIP1	SH3 domain GRB2 like endophilin interacting protein 1. (855 aa)
	APLN	Apelin. (77 aa)
	ATAD1	ATPase family AAA domain containing 1; Belongs to the AAA ATPase family. (362 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1. (308 aa)
	APELA	Apelin receptor early endogenous ligand. (54 aa)
	DAB2	DAB adaptor protein 2. (767 aa)
	WASL	WASP like actin nucleation promoting factor. (507 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (402 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
	ENSCCAP00000021074	Uncharacterized protein. (313 aa)
	DNM2	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
	CLUL1	Clusterin; Belongs to the clusterin family. (469 aa)
	C3	Complement C3. (1664 aa)
	CBL	Cbl proto-oncogene. (909 aa)
	DGKD	Diacylglycerol kinase. (1224 aa)
	CCL19	C-C motif chemokine. (98 aa)
	LOC108284754	Annexin. (339 aa)
	SELE	Selectin E. (610 aa)
	SFRP4	Secreted frizzled related protein 4. (368 aa)
	APOA5	Apolipoprotein A5. (366 aa)
	HFE	Homeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
	TF	Transferrin; Belongs to the transferrin family. (700 aa)
	TBC1D5	TBC1 domain family member 5. (839 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9. (690 aa)
	DTNBP1	Dystrobrevin binding protein 1. (351 aa)
	PPT1	Palmitoyl-protein thioesterase 1. (306 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
	CD63	Tetraspanin. (238 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (272 aa)

Your Current Organism:

Cebus capucinus

NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANGPT1	INSR	ENSCCAP00000009606	ENSCCAP00000011036	Angiopoietin 1.	Tyrosine-protein kinase receptor.	0.762
ANXA2	CD63	ENSCCAP00000010058	ENSCCAP00000037944	Annexin.	Tetraspanin.	0.414
APELA	APLN	ENSCCAP00000019252	ENSCCAP00000016707	Apelin receptor early endogenous ligand.	Apelin.	0.591
APLN	APELA	ENSCCAP00000016707	ENSCCAP00000019252	Apelin.	Apelin receptor early endogenous ligand.	0.591
APOA5	CLU	ENSCCAP00000029981	ENSCCAP00000004409	Apolipoprotein A5.	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	0.470
ARRB1	ARRB2	ENSCCAP00000009465	ENSCCAP00000005576	Arrestin beta 1.	Arrestin beta 2.	0.981
ARRB1	DAB2	ENSCCAP00000009465	ENSCCAP00000019298	Arrestin beta 1.	DAB adaptor protein 2.	0.491
ARRB1	DNM2	ENSCCAP00000009465	ENSCCAP00000022060	Arrestin beta 1.	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.570
ARRB1	SGIP1	ENSCCAP00000009465	ENSCCAP00000014096	Arrestin beta 1.	SH3 domain GRB2 like endophilin interacting protein 1.	0.423
ARRB2	ARRB1	ENSCCAP00000005576	ENSCCAP00000009465	Arrestin beta 2.	Arrestin beta 1.	0.981
ARRB2	DAB2	ENSCCAP00000005576	ENSCCAP00000019298	Arrestin beta 2.	DAB adaptor protein 2.	0.431
ARRB2	DNM2	ENSCCAP00000005576	ENSCCAP00000022060	Arrestin beta 2.	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.667
ARRB2	SGIP1	ENSCCAP00000005576	ENSCCAP00000014096	Arrestin beta 2.	SH3 domain GRB2 like endophilin interacting protein 1.	0.423
B2M	HFE	ENSCCAP00000020514	ENSCCAP00000033262	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Homeostatic iron regulator; Belongs to the MHC class I family.	0.956
C3	CLU	ENSCCAP00000023755	ENSCCAP00000004409	Complement C3.	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	0.596
C3	CLUL1	ENSCCAP00000023755	ENSCCAP00000023579	Complement C3.	Clusterin; Belongs to the clusterin family.	0.584
CBL	DAB2	ENSCCAP00000025290	ENSCCAP00000019298	Cbl proto-oncogene.	DAB adaptor protein 2.	0.545
CBL	EGF	ENSCCAP00000025290	ENSCCAP00000037928	Cbl proto-oncogene.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.667
CBL	INSR	ENSCCAP00000025290	ENSCCAP00000011036	Cbl proto-oncogene.	Tyrosine-protein kinase receptor.	0.904
CBL	LDLRAP1	ENSCCAP00000025290	ENSCCAP00000017886	Cbl proto-oncogene.	Low density lipoprotein receptor adaptor protein 1.	0.492