(112 nodes) Negative regulation of developmental growth network (Cebus capucinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GNAS	GNAS complex locus. (1044 aa)
	GSK3A	Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
	MAP2	Microtubule-associated protein. (1830 aa)
	MAPK11	Mitogen-activated protein kinase. (368 aa)
	SEMA4F	Ssemaphorin 4F; Belongs to the semaphorin family. (770 aa)
	KIAA0319	KIAA0319. (1072 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (927 aa)
	BCL11A	BAF chromatin remodeling complex subunit BCL11A. (835 aa)
	ULK2	Unc-51 like autophagy activating kinase 2. (1022 aa)
	RNF6	Ring finger protein 6. (685 aa)
	SEMA4G	Semaphorin 4G; Belongs to the semaphorin family. (844 aa)
	MSTN	Myostatin. (375 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	CDKN1B	Cyclin dependent kinase inhibitor 1B. (205 aa)
	SEMA4C	Semaphorin 4C; Belongs to the semaphorin family. (874 aa)
	FGF13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	SPART	Spartin. (660 aa)
	LGMN	Uncharacterized protein. (433 aa)
	ENSCCAP00000032585	Uncharacterized protein. (144 aa)
	NKD1	NKD inhibitor of WNT signaling pathway 1. (470 aa)
	G6PD	Uncharacterized protein. (560 aa)
	SPP1	Secreted phosphoprotein 1. (314 aa)
	DIP2B	Disco interacting protein 2 homolog B. (1542 aa)
	BBS2	Bardet-Biedl syndrome 2. (614 aa)
	LOC108316220	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (501 aa)
	PTPRS	Protein tyrosine phosphatase receptor type S. (1948 aa)
	SEMA4A	Semaphorin 4A; Belongs to the semaphorin family. (661 aa)
	FOXP1	Forkhead box P1. (693 aa)
	SEMA3A	Semaphorin 3A; Belongs to the semaphorin family. (772 aa)
	VGLL4	Vestigial like family member 4. (296 aa)
	PI16	Peptidase inhibitor 16; Belongs to the CRISP family. (463 aa)
	IFRD1	Uncharacterized protein. (451 aa)
	TOMM70	Translocase of outer mitochondrial membrane 70. (608 aa)
	SEMA6B	Semaphorin 6B; Belongs to the semaphorin family. (891 aa)
	SEMA5B	Semaphorin 5B. (1179 aa)
	SEMA3D	Semaphorin 3D; Belongs to the semaphorin family. (723 aa)
	MAG	Myelin associated glycoprotein. (626 aa)
	NTN1	Netrin 1. (604 aa)
	RTN4	Reticulon. (1194 aa)
	LOC108285920	Uncharacterized protein. (248 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
	FGFR3	Fibroblast growth factor receptor. (808 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	PLXNA3	Plexin A3. (1871 aa)
	SEMA5A	Semaphorin 5A. (1074 aa)
	MT3	Metallothionein 3; Belongs to the metallothionein superfamily. Type 1 family. (113 aa)
	SEMA3E	Semaphorin 3E; Belongs to the semaphorin family. (774 aa)
	RGS2	Regulator of G protein signaling 2. (211 aa)
	SEMA3B	Semaphorin 3B; Belongs to the semaphorin family. (755 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (635 aa)
	ADRB2	Adrenoceptor beta 2. (447 aa)
	LOC108298696	Uncharacterized protein. (349 aa)
	FSTL4	Follistatin like 4. (842 aa)
	TNR	Tenascin R. (1358 aa)
	ENSCCAP00000018918	Uncharacterized protein. (406 aa)
	ENSCCAP00000018890	ANK_REP_REGION domain-containing protein. (530 aa)
	ENSCCAP00000018301	Uncharacterized protein. (279 aa)
	DUSP10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
	OSTN	Osteocrin. (133 aa)
	STK4	Serine/threonine kinase 4. (487 aa)
	RYK	Receptor like tyrosine kinase. (613 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	SOCS2	Suppressor of cytokine signaling 2. (199 aa)
	DSPP	Dentin sialophosphoprotein. (1029 aa)
	ULK1	Unc-51 like autophagy activating kinase 1. (964 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	STK3	Serine/threonine kinase 3. (523 aa)
	ARHGAP4	Rho GTPase activating protein 4. (966 aa)
	WWC2	WW and C2 domain containing 2. (1196 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (158 aa)
	GDF15	Growth differentiation factor 15. (308 aa)
	SLC6A4	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
	ENSCCAP00000013944	Uncharacterized protein. (340 aa)
	PLAC8	Placenta associated 8. (113 aa)
	SEMA7A	Semaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (661 aa)
	SEMA4B	Semaphorin 4B; Belongs to the semaphorin family. (835 aa)
	TLL2	Metalloendopeptidase. (1014 aa)
	ENSCCAP00000013029	CCDC144C domain-containing protein. (1062 aa)
	SLIT1	Slit guidance ligand 1. (1534 aa)
	SEMA6C	Semaphorin 6C; Belongs to the semaphorin family. (962 aa)
	RAI1	Retinoic acid induced 1. (1870 aa)
	SAV1	Salvador family WW domain containing protein 1. (384 aa)
	WWC1	WW and C2 domain containing 1. (1111 aa)
	KCNK2	Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
	CTDP1	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (964 aa)
	EPHA7	EPH receptor A7. (998 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
	PTCH1	Patched 1. (1452 aa)
	MYOZ1	Myozenin 1. (299 aa)
	LOC108297694	ANK_REP_REGION domain-containing protein. (307 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	IFRD2	Interferon related developmental regulator 2. (507 aa)
	SEMA6A	Semaphorin 6A; Belongs to the semaphorin family. (1047 aa)
	ENSCCAP00000006464	Uncharacterized protein. (60 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (322 aa)
	ENSCCAP00000005633	Uncharacterized protein. (371 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	SEMA3F	Semaphorin 3F; Belongs to the semaphorin family. (786 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (275 aa)
	RTN4R	Reticulon 4 receptor. (474 aa)
	DRAXIN	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (350 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (1240 aa)
	SPAG9	Sperm associated antigen 9. (1321 aa)
	TRIM46	Tripartite motif containing 46. (759 aa)
	DCC	DCC netrin 1 receptor. (1447 aa)
	WWC3	WWC family member 3. (1217 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (862 aa)
	LOC108298339	Uncharacterized protein. (164 aa)
	SEMA3G	Semaphorin 3G; Belongs to the semaphorin family. (782 aa)
	FXN	Uncharacterized protein. (213 aa)

Your Current Organism:

Cebus capucinus

NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRB2	CAV3	ENSCCAP00000020263	ENSCCAP00000024638	Adrenoceptor beta 2.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.475
ADRB2	ENSCCAP00000013944	ENSCCAP00000020263	ENSCCAP00000013944	Adrenoceptor beta 2.	Uncharacterized protein.	0.942
ADRB2	ENSCCAP00000018301	ENSCCAP00000020263	ENSCCAP00000018301	Adrenoceptor beta 2.	Uncharacterized protein.	0.942
ADRB2	GNAS	ENSCCAP00000020263	ENSCCAP00000006125	Adrenoceptor beta 2.	GNAS complex locus.	0.942
ADRB2	LOC108285920	ENSCCAP00000020263	ENSCCAP00000025065	Adrenoceptor beta 2.	Uncharacterized protein.	0.882
ADRB2	LOC108298339	ENSCCAP00000020263	ENSCCAP00000000879	Adrenoceptor beta 2.	Uncharacterized protein.	0.942
ADRB2	LOC108298696	ENSCCAP00000020263	ENSCCAP00000019965	Adrenoceptor beta 2.	Uncharacterized protein.	0.942
BMP4	DCC	ENSCCAP00000036602	ENSCCAP00000002014	Bone morphogenetic protein 4.	DCC netrin 1 receptor.	0.519
BMP4	FSTL4	ENSCCAP00000036602	ENSCCAP00000019390	Bone morphogenetic protein 4.	Follistatin like 4.	0.750
BMP4	GDF15	ENSCCAP00000036602	ENSCCAP00000014297	Bone morphogenetic protein 4.	Growth differentiation factor 15.	0.473
BMP4	NOG	ENSCCAP00000036602	ENSCCAP00000005156	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.997
BMP4	PTCH1	ENSCCAP00000036602	ENSCCAP00000007815	Bone morphogenetic protein 4.	Patched 1.	0.418
BMP4	TBX5	ENSCCAP00000036602	ENSCCAP00000015385	Bone morphogenetic protein 4.	T-box transcription factor 5.	0.514
BMP4	TGFBR2	ENSCCAP00000036602	ENSCCAP00000009387	Bone morphogenetic protein 4.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.478
BMP4	WNT3	ENSCCAP00000036602	ENSCCAP00000023587	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.679
BMP4	WNT3A	ENSCCAP00000036602	ENSCCAP00000001449	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.659
CAV3	ADRB2	ENSCCAP00000024638	ENSCCAP00000020263	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Adrenoceptor beta 2.	0.475
CDK5	CDKN1A	ENSCCAP00000006190	ENSCCAP00000014399	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1A.	0.622
CDK5	CDKN1B	ENSCCAP00000006190	ENSCCAP00000036474	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1B.	0.812
CDK5	GSK3A	ENSCCAP00000006190	ENSCCAP00000040661	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily.	0.485