STRINGSTRING
VEGFD VEGFD MYDGF MYDGF RUNX2 RUNX2 MED1 MED1 PKHD1 PKHD1 ENSCCAP00000000807 ENSCCAP00000000807 ENSCCAP00000000866 ENSCCAP00000000866 SOX11 SOX11 SPINK1 SPINK1 WNT3A WNT3A B4GALT1 B4GALT1 BAD BAD SOX9 SOX9 BTK BTK NRARP NRARP FLT4 FLT4 JUND JUND SMO SMO APLNR APLNR LOC108311244 LOC108311244 REG3A REG3A THBS4 THBS4 LRG1 LRG1 BMP2 BMP2 ATP7A ATP7A DLX5 DLX5 ENSCCAP00000003550 ENSCCAP00000003550 FOXE3 FOXE3 JCAD JCAD HSF4 HSF4 ZNF580 ZNF580 PGF PGF NOG NOG LACRT LACRT ODAM ODAM ARG1 ARG1 VEGFB VEGFB LOC108292702 LOC108292702 CXCL12 CXCL12 CYBA CYBA PIK3CD PIK3CD FGF9 FGF9 SIRT6 SIRT6 RREB1 RREB1 ID1 ID1 IRS2 IRS2 CRNN CRNN GHRL GHRL CCR3 CCR3 CLDN1 CLDN1 EMC10 EMC10 DLX6 DLX6 HMOX1 HMOX1 AR AR ENSCCAP00000010305 ENSCCAP00000010305 VEGFC VEGFC CDH3 CDH3 AKT3 AKT3 AGGF1 AGGF1 REG3G REG3G CAV2 CAV2 FGF2 FGF2 PLCG1 PLCG1 PRKCA PRKCA SCN5A SCN5A EGFR EGFR ENSCCAP00000012370 ENSCCAP00000012370 GATA2 GATA2 ENSCCAP00000012659 ENSCCAP00000012659 BMP5 BMP5 BMP6 BMP6 PLXNB3 PLXNB3 STAT5A STAT5A NR4A3 NR4A3 GDF2 GDF2 BMPR2 BMPR2 HMGA2 HMGA2 REG1B REG1B SAAL1 SAAL1 TNFSF12 TNFSF12 EPGN EPGN IQGAP3 IQGAP3 CTNNB1 CTNNB1 SRSF6 SRSF6 ECM1 ECM1 APLN APLN FGFR1 FGFR1 ESRP2 ESRP2 NRP2 NRP2 WNT5A WNT5A TNFAIP3 TNFAIP3 CCL26 CCL26 IGF2 IGF2 ENSCCAP00000017839 ENSCCAP00000017839 F3 F3 STAT3 STAT3 TP63 TP63 CCL24 CCL24 KDR KDR APELA APELA NF1 NF1 HMX2 HMX2 TBX1 TBX1 TNF TNF HTR2B HTR2B GHSR GHSR CCND1 CCND1 CYP7B1 CYP7B1 HIF1A HIF1A HTRA1 HTRA1 FGFR2 FGFR2 XBP1 XBP1 SEMA5A SEMA5A OSR1 OSR1 ST8SIA1 ST8SIA1 ZNF703 ZNF703 ARNT ARNT ENSCCAP00000023536 ENSCCAP00000023536 SIRT1 SIRT1 KDM5B KDM5B MST1 MST1 LAMC1 LAMC1 PPP1R16B PPP1R16B MAP2K5 MAP2K5 NKX2-5 NKX2-5 SFRP1 SFRP1 ZNF304 ZNF304 MDK MDK STXBP4 STXBP4 AGAP2 AGAP2 FGF10 FGF10 EGR3 EGR3 RTN4 RTN4 NKX2-6 NKX2-6 EYA1 EYA1 TACR1 TACR1 PDGFB PDGFB NRAS NRAS TGFB1 TGFB1 WNT7A WNT7A PROK1 PROK1 TCF7L2 TCF7L2 HRAS HRAS ZBED9 ZBED9 LOC108293547 LOC108293547 ACVRL1 ACVRL1 WNT2 WNT2 PRKD2 PRKD2 TGFA TGFA VEGFA VEGFA NODAL NODAL ERBB2 ERBB2 MYC MYC PTPRN PTPRN ITGB3 ITGB3 TEK TEK TGFBR1 TGFBR1 ITGA4 ITGA4 VIP VIP MMP12 MMP12 SHH SHH PTN PTN LOC108312238 LOC108312238 TGM1 TGM1 NOTCH1 NOTCH1 BMPR1A BMPR1A GRN GRN MTA3 MTA3 NOD2 NOD2 OSR2 OSR2 VASH2 VASH2 YAP1 YAP1 C5AR1 C5AR1 PROX1 PROX1 AKT1 AKT1 IL10 IL10 PRKD1 PRKD1 ADAM17 ADAM17 PAX2 PAX2 HYAL1 HYAL1 BMP4 BMP4 HLX HLX PDX1 PDX1 ENSCCAP00000036868 ENSCCAP00000036868 RPTOR RPTOR IHH IHH IGF1 IGF1 NR4A1 NR4A1 LOC108282374 LOC108282374 EGF EGF AREG AREG JAML JAML PDPK1 PDPK1 AGTR1 AGTR1 IL18 IL18 NRP1 NRP1 FGF7 FGF7 FGF1 FGF1 HAS2 HAS2 SP1 SP1 HPN HPN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (356 aa)
MYDGFMyeloid derived growth factor. (190 aa)
RUNX2RUNX family transcription factor 2. (540 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4074 aa)
ENSCCAP00000000807Uncharacterized protein. (144 aa)
ENSCCAP00000000866Uncharacterized protein. (141 aa)
SOX11Transcription factor SOX. (450 aa)
SPINK1Serine peptidase inhibitor, Kazal type 1. (79 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (400 aa)
BADBCL2 associated agonist of cell death. (167 aa)
SOX9SRY-box transcription factor 9. (509 aa)
BTKTyrosine-protein kinase. (598 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (350 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
LOC108311244Nucleoside diphosphate kinase. (146 aa)
REG3ARegenerating family member 3 alpha. (175 aa)
THBS4Thrombospondin 4. (961 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (348 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
ATP7AATPase copper transporting alpha. (1476 aa)
DLX5Distal-less homeobox 5. (289 aa)
ENSCCAP00000003550Uncharacterized protein. (291 aa)
FOXE3Forkhead box E3. (319 aa)
JCADJunctional cadherin 5 associated. (1350 aa)
HSF4Heat shock transcription factor 4. (492 aa)
ZNF580Zinc finger protein 580. (172 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (199 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
LACRTLacritin. (137 aa)
ODAMOdontogenic, ameloblast associated. (279 aa)
ARG1Arginase. (322 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
LOC108292702CTNNB1_binding domain-containing protein. (169 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (193 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1056 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SIRT6Sirtuin 6. (382 aa)
RREB1Ras responsive element binding protein 1. (1744 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (151 aa)
IRS2Insulin receptor substrate 2. (1361 aa)
CRNNCornulin. (431 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
EMC10ER membrane protein complex subunit 10. (260 aa)
DLX6Distal-less homeobox 6. (291 aa)
HMOX1Heme oxygenase 1. (297 aa)
ARAndrogen receptor. (887 aa)
ENSCCAP00000010305Uncharacterized protein. (181 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (829 aa)
AKT3AKT serine/threonine kinase 3. (472 aa)
AGGF1Uncharacterized protein. (722 aa)
REG3GRegenerating family member 3 gamma. (175 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1302 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ENSCCAP00000012370ANK_REP_REGION domain-containing protein. (518 aa)
GATA2GATA binding protein 2. (480 aa)
ENSCCAP00000012659RESP18 domain-containing protein. (91 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
BMP6Bone morphogenetic protein 6. (508 aa)
PLXNB3Plexin B3. (1952 aa)
STAT5ASignal transducer and activator of transcription. (796 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (723 aa)
GDF2Growth differentiation factor 2. (429 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (961 aa)
HMGA2Uncharacterized protein. (118 aa)
REG1BRegenerating family member 1 beta. (166 aa)
SAAL1Serum amyloid A like 1. (473 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (249 aa)
EPGNEpithelial mitogen. (154 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1632 aa)
CTNNB1Catenin beta 1. (781 aa)
SRSF6Serine and arginine rich splicing factor 6. (344 aa)
ECM1Extracellular matrix protein 1. (565 aa)
APLNApelin. (77 aa)
FGFR1Fibroblast growth factor receptor. (827 aa)
ESRP2Epithelial splicing regulatory protein 2. (715 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (925 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TNFAIP3TNF alpha induced protein 3. (804 aa)
CCL26C-C motif chemokine ligand 26. (93 aa)
IGF2Insulin like growth factor 2. (236 aa)
ENSCCAP00000017839Uncharacterized protein. (136 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (295 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
NF1Neurofibromin 1. (2839 aa)
HMX2H6 family homeobox 2. (273 aa)
TBX1T-box transcription factor 1. (495 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (505 aa)
HIF1AUncharacterized protein. (848 aa)
HTRA1HtrA serine peptidase 1. (483 aa)
FGFR2Fibroblast growth factor receptor. (782 aa)
XBP1BZIP domain-containing protein. (375 aa)
SEMA5ASemaphorin 5A. (1074 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa)
ZNF703Zinc finger protein 703. (590 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
ENSCCAP00000023536PTN_MK_N domain-containing protein. (92 aa)
SIRT1Sirtuin 1. (446 aa)
KDM5BLysine demethylase 5B. (1516 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
PPP1R16BProtein phosphatase 1 regulatory subunit 16B. (567 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
NKX2-5NK2 homeobox 5. (324 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
ZNF304Zinc finger protein 304. (691 aa)
MDKUncharacterized protein. (144 aa)
STXBP4Syntaxin binding protein 4. (554 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1192 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
EGR3Early growth response 3. (387 aa)
RTN4Reticulon. (1194 aa)
NKX2-6NK2 homeobox 6. (301 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (610 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
NRASUncharacterized protein. (189 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (314 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
PROK1Prokineticin 1. (105 aa)
TCF7L2Transcription factor 7 like 2. (430 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ZBED9Zinc finger BED-type containing 9. (1326 aa)
LOC108293547Uncharacterized protein. (773 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (860 aa)
TGFATransforming growth factor alpha. (165 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (456 aa)
NODALNodal growth differentiation factor. (347 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (983 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (939 aa)
TEKTEK receptor tyrosine kinase. (1069 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (496 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
VIPVasoactive intestinal peptide. (170 aa)
MMP12Matrix metallopeptidase 12. (469 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (464 aa)
PTNUncharacterized protein. (168 aa)
LOC108312238Nucleoside diphosphate kinase. (143 aa)
TGM1Transglutaminase 1. (814 aa)
NOTCH1Notch receptor 1. (2550 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (432 aa)
GRNGranulin precursor. (595 aa)
MTA3Metastasis associated 1 family member 3. (594 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
OSR2Odd-skipped related transciption factor 2. (417 aa)
VASH2Vasohibin 2. (355 aa)
YAP1Uncharacterized protein. (506 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (347 aa)
PROX1Prospero homeobox 1. (737 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (489 aa)
IL10Interleukin 10. (178 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (884 aa)
ADAM17ADAM metallopeptidase domain 17. (914 aa)
PAX2Paired box 2. (417 aa)
HYAL1Hyaluronidase. (435 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
HLXH2.0 like homeobox. (492 aa)
PDX1Pancreatic and duodenal homeobox 1. (282 aa)
ENSCCAP00000036868Uncharacterized protein. (201 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1305 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
IGF1Insulin like growth factor 1. (199 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (652 aa)
LOC108282374Uncharacterized protein. (330 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
AREGAmphiregulin. (275 aa)
JAMLUncharacterized protein. (393 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (562 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (388 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (927 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
HAS2Hyaluronan synthase 2. (552 aa)
SP1Sp1 transcription factor. (786 aa)
HPNHepsin; Belongs to the peptidase S1 family. (425 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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