STRINGSTRING
EFNA1 EFNA1 CD74 CD74 PIBF1 PIBF1 IL2 IL2 ARL2BP ARL2BP EPGN EPGN ERCC6 ERCC6 ENSCCAP00000013863 ENSCCAP00000013863 CNTF CNTF ABL1 ABL1 BMP6 BMP6 ENSCCAP00000012889 ENSCCAP00000012889 IL12B IL12B EGFR EGFR NCF1 NCF1 ENSCCAP00000011943 ENSCCAP00000011943 ENSCCAP00000011942 ENSCCAP00000011942 IL6 IL6 ENSCCAP00000011842 ENSCCAP00000011842 FBXW7 FBXW7 IL4 IL4 GRM5 GRM5 CD81 CD81 IL34 IL34 PAK2 PAK2 JAK2 JAK2 TSLP TSLP FLT3 FLT3 CD80 CD80 ANGPT1 ANGPT1 ACE ACE GHRL GHRL ENSCCAP00000008905 ENSCCAP00000008905 SRC SRC ACVR1 ACVR1 ITGA5 ITGA5 TREM2 TREM2 PLCG2 PLCG2 DLG3 DLG3 VEGFB VEGFB GDNF GDNF HTR2A HTR2A AFAP1L2 AFAP1L2 ENSCCAP00000005270 ENSCCAP00000005270 LACRT LACRT MIF MIF ISL1 ISL1 PECAM1 PECAM1 DOK7 DOK7 SYK SYK GFRA1 GFRA1 MLST8 MLST8 ADRA1A ADRA1A THBS4 THBS4 OSM OSM CASS4 CASS4 IL23A IL23A IL21 IL21 WNT3A WNT3A CNTN1 CNTN1 IL6ST IL6ST AGT AGT SEMA4D SEMA4D PLPP3 PLPP3 NEDD9 NEDD9 TNFRSF18 TNFRSF18 BTC BTC RELN RELN SH2D1B SH2D1B FGF7 FGF7 EPHA4 EPHA4 ANGPT4 ANGPT4 BANK1 BANK1 NRP1 NRP1 IL18 IL18 HPX HPX NTF3 NTF3 YES1 YES1 PARP9 PARP9 AREG AREG EGF EGF EREG EREG ERBB4 ERBB4 IGF1 IGF1 TNFRSF1A TNFRSF1A IL5 IL5 LOC108316383 LOC108316383 ALKAL1 ALKAL1 IL6R IL6R HDAC2 HDAC2 DLG4 DLG4 ADAM17 ADAM17 PTK6 PTK6 NRG1 NRG1 HGF HGF CD3E CD3E ENSCCAP00000034027 ENSCCAP00000034027 LRP4 LRP4 NOD2 NOD2 IL12A IL12A CD24 CD24 IL15 IL15 LOC108293862 LOC108293862 ERBB3 ERBB3 CSF2 CSF2 ADNP ADNP PTPN11 PTPN11 CSF1R CSF1R HBEGF HBEGF CLCF1 CLCF1 ALK ALK KIT KIT CSF3 CSF3 CSPG4 CSPG4 EPO EPO ITGB3 ITGB3 HCLS1 HCLS1 STAP1 STAP1 CD36 CD36 TP53 TP53 DVL2 DVL2 GATA1 GATA1 IL3 IL3 VEGFA VEGFA TGFA TGFA LIF LIF LOC108318254 LOC108318254 CD4 CD4 UNC119 UNC119 CD40 CD40 TNK2 TNK2 ADIPOQ ADIPOQ TGFB1 TGFB1 GAS6 GAS6 EHD4 EHD4 RIPK2 RIPK2 LOC108314184 LOC108314184 LRRK1 LRRK1 PDGFB PDGFB DGKQ DGKQ CTF1 CTF1 FGF10 FGF10 FGFR3 FGFR3 PTPRC PTPRC SRCIN1 SRCIN1 OSBP OSBP ARHGEF2 ARHGEF2 IL20 IL20 PTPRJ PTPRJ LTK LTK ENPP2 ENPP2 HSF1 HSF1 NEURL1 NEURL1 CLEC6A CLEC6A PARP14 PARP14 RICTOR RICTOR GPRC5B GPRC5B FYN FYN FGF8 FGF8 MTOR MTOR IL31RA IL31RA DOCK3 DOCK3 CD44 CD44 ENSCCAP00000019950 ENSCCAP00000019950 ENSCCAP00000019834 ENSCCAP00000019834 HAX1 HAX1 LRP8 LRP8 CRLF1 CRLF1 ALKAL2 ALKAL2 ABI1 ABI1 IFNG IFNG IL24 IL24 EFNA5 EFNA5 FBXW9 FBXW9 ENSCCAP00000018427 ENSCCAP00000018427 PTK2B PTK2B HES5 HES5 KITLG KITLG ENSCCAP00000017748 ENSCCAP00000017748 IGF2 IGF2 LYN LYN TNFSF18 TNFSF18 IL23R IL23R TDGF1 TDGF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
CD74CD74 molecule. (308 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (757 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
ARL2BPADP ribosylation factor like GTPase 2 binding protein. (130 aa)
EPGNEpithelial mitogen. (154 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1498 aa)
ENSCCAP00000013863Uncharacterized protein. (222 aa)
CNTFCiliary neurotrophic factor. (200 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
BMP6Bone morphogenetic protein 6. (508 aa)
ENSCCAP00000012889Uncharacterized protein. (111 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
ENSCCAP00000011943Uncharacterized protein. (281 aa)
ENSCCAP00000011942Protein kinase domain-containing protein. (258 aa)
IL6Interleukin 6. (212 aa)
ENSCCAP00000011842Uncharacterized protein. (284 aa)
FBXW7F-box and WD repeat domain containing 7. (740 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (152 aa)
GRM5Glutamate metabotropic receptor 5. (934 aa)
CD81Tetraspanin. (236 aa)
IL34Interleukin 34. (242 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
JAK2Tyrosine-protein kinase. (1136 aa)
TSLPThymic stromal lymphopoietin. (158 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (962 aa)
CD80CD80 molecule. (292 aa)
ANGPT1Angiopoietin 1. (498 aa)
ACEAngiotensin-converting enzyme. (1308 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
ENSCCAP00000008905Uncharacterized protein. (76 aa)
SRCTyrosine-protein kinase. (542 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1050 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (863 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
AFAP1L2Actin filament associated protein 1 like 2. (817 aa)
ENSCCAP00000005270Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (389 aa)
LACRTLacritin. (137 aa)
MIFUncharacterized protein. (115 aa)
ISL1ISL LIM homeobox 1. (349 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (738 aa)
DOK7Docking protein 7. (501 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
GFRA1GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (467 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
ADRA1AAdrenoceptor alpha 1A. (466 aa)
THBS4Thrombospondin 4. (961 aa)
OSMOncostatin M. (228 aa)
CASS4Cas scaffold protein family member 4. (784 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
CNTN1Contactin 1. (1028 aa)
IL6STInterleukin 6 signal transducer. (919 aa)
AGTAngiotensinogen; Belongs to the serpin family. (486 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
PLPP3acidPPc domain-containing protein. (311 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (834 aa)
TNFRSF18Uncharacterized protein. (234 aa)
BTCBetacellulin. (178 aa)
RELNReelin. (3278 aa)
SH2D1BSH2 domain containing 1B. (132 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
EPHA4EPH receptor A4. (949 aa)
ANGPT4Angiopoietin 4. (503 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (797 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (927 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
HPXHemopexin. (414 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (272 aa)
YES1Tyrosine-protein kinase. (441 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (817 aa)
AREGAmphiregulin. (275 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
EREGEpiregulin. (169 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
IGF1Insulin like growth factor 1. (199 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
LOC108316383Ig-like domain-containing protein. (193 aa)
ALKAL1ALK and LTK ligand 1. (129 aa)
IL6RInterleukin 6 receptor. (468 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (763 aa)
ADAM17ADAM metallopeptidase domain 17. (914 aa)
PTK6Tyrosine-protein kinase. (451 aa)
NRG1Neuregulin 1. (713 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
CD3ECD3e molecule. (198 aa)
ENSCCAP00000034027Tyrosine-protein kinase. (360 aa)
LRP4LDL receptor related protein 4. (1905 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (289 aa)
CD24Uncharacterized protein. (78 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
LOC108293862Uncharacterized protein. (239 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1352 aa)
CSF2Colony stimulating factor 2. (144 aa)
ADNPActivity dependent neuroprotector homeobox. (1103 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (961 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
CLCF1Cardiotrophin like cytokine factor 1. (225 aa)
ALKTyrosine-protein kinase receptor. (1621 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
CSF3Colony stimulating factor 3. (207 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (2322 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (194 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (939 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (471 aa)
STAP1Signal transducing adaptor family member 1. (295 aa)
CD36CD36 molecule; Belongs to the CD36 family. (476 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (395 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
GATA1GATA binding protein 1. (413 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (142 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (456 aa)
TGFATransforming growth factor alpha. (165 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
LOC108318254Uncharacterized protein. (223 aa)
CD4CD4 molecule. (457 aa)
UNC119Unc-119 lipid binding chaperone. (240 aa)
CD40CD40 molecule. (274 aa)
TNK2Tyrosine kinase non receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1085 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (314 aa)
GAS6Growth arrest specific 6. (676 aa)
EHD4EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (541 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
LOC108314184ARL2_Bind_BART domain-containing protein. (171 aa)
LRRK1Leucine rich repeat kinase 1. (2014 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
DGKQDiacylglycerol kinase. (938 aa)
CTF1Cardiotrophin 1. (203 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1299 aa)
SRCIN1SRC kinase signaling inhibitor 1. (1216 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (804 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
IL20Interleukin 20. (176 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1258 aa)
LTKTyrosine-protein kinase receptor. (863 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (904 aa)
HSF1Heat shock transcription factor 1. (532 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (574 aa)
CLEC6AC-type lectin domain containing 6A. (209 aa)
PARP14Poly [ADP-ribose] polymerase. (1792 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
GPRC5BG protein-coupled receptor class C group 5 member B. (404 aa)
FYNTyrosine-protein kinase. (537 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
MTORSerine/threonine-protein kinase mTOR. (2508 aa)
IL31RAInterleukin 31 receptor A. (744 aa)
DOCK3Dedicator of cytokinesis 3; Belongs to the DOCK family. (2030 aa)
CD44CD44 molecule (Indian blood group). (734 aa)
ENSCCAP00000019950Uncharacterized protein. (79 aa)
ENSCCAP00000019834Uncharacterized protein. (229 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (275 aa)
LRP8LDL receptor related protein 8. (958 aa)
CRLF1Cytokine receptor like factor 1. (421 aa)
ALKAL2ALK and LTK ligand 2. (152 aa)
ABI1Abl interactor 1. (508 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IL24Interleukin 24. (206 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
FBXW9F-box and WD repeat domain containing 9. (477 aa)
ENSCCAP00000018427SH2 domain-containing protein. (239 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (990 aa)
HES5Hes family bHLH transcription factor 5. (162 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (268 aa)
ENSCCAP00000017748ANF_receptor domain-containing protein. (249 aa)
IGF2Insulin like growth factor 2. (236 aa)
LYNTyrosine-protein kinase. (491 aa)
TNFSF18TNF superfamily member 18. (199 aa)
IL23RInterleukin 23 receptor. (630 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (187 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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