STRINGSTRING
PLN PLN CD19 CD19 FKBP1B FKBP1B TRDN TRDN CEMIP CEMIP PTPN6 PTPN6 NOS1 NOS1 CASQ2 CASQ2 NTSR1 NTSR1 APLNR APLNR TPCN1 TPCN1 JPH3 JPH3 ASPH ASPH P2RY6 P2RY6 CLIC2 CLIC2 LACRT LACRT HTR2A HTR2A PLCG2 PLCG2 CYBA CYBA MCOLN2 MCOLN2 PDE4D PDE4D CORO1A CORO1A ATG5 ATG5 SLC25A23 SLC25A23 UBASH3B UBASH3B LETM1 LETM1 RYR1 RYR1 JSRP1 JSRP1 LOC108313439 LOC108313439 DIAPH1 DIAPH1 PLCG1 PLCG1 BAX BAX JPH1 JPH1 LOC108315475 LOC108315475 CXCL11 CXCL11 ABL1 ABL1 CXCL9 CXCL9 NOL3 NOL3 CCR7 CCR7 SLC8B1 SLC8B1 LOC108318662 LOC108318662 AKAP6 AKAP6 CHD7 CHD7 LYN LYN SRI SRI BBC3 BBC3 IBTK IBTK ANK2 ANK2 PTK2B PTK2B FLNA FLNA JPH4 JPH4 HTR2B HTR2B LOC108294424 LOC108294424 TMEM38A TMEM38A DMD DMD F2 F2 ITPR1 ITPR1 ENSCCAP00000022396 ENSCCAP00000022396 LIME1 LIME1 ENSCCAP00000023374 ENSCCAP00000023374 ITPR3 ITPR3 CXCL10 CXCL10 HTT HTT ERO1A ERO1A PTPRC PTPRC BDKRB1 BDKRB1 PRKCE PRKCE THY1 THY1 RYR3 RYR3 CAPN3 CAPN3 DDIT3 DDIT3 TGFB1 TGFB1 SLC8A1 SLC8A1 SELENON SELENON CHERP CHERP ENSCCAP00000027698 ENSCCAP00000027698 HRC HRC CCL19 CCL19 TRPA1 TRPA1 RASA3 RASA3 GPER1 GPER1 CAMK2D CAMK2D METTL21C METTL21C JPH2 JPH2 TMEM38B TMEM38B ITGB3 ITGB3 CALM3 CALM3 F2RL3 F2RL3 HTR2C HTR2C PKD2 PKD2 MTLN MTLN TRPC1 TRPC1 GSTO1 GSTO1 DHRS7C DHRS7C ITPR2 ITPR2 TPCN2 TPCN2 F2R F2R PRKD1 PRKD1 TRPM2 TRPM2 NPSR1 NPSR1 CASQ1 CASQ1 CCL21 CCL21 CX3CL1 CX3CL1 FASLG FASLG CACNA1C CACNA1C PDPK1 PDPK1 RYR2 RYR2 TRPV1 TRPV1 CXCR3 CXCR3 ANXA6 ANXA6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
CD19CD19 molecule. (559 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
TRDNTriadin. (722 aa)
CEMIPCell migration inducing hyaluronidase 1. (1361 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (608 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (402 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (415 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
TPCN1Two pore segment channel 1. (888 aa)
JPH3Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (748 aa)
ASPHAspartate beta-hydroxylase. (606 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
CLIC2Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (247 aa)
LACRTLacritin. (137 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (193 aa)
MCOLN2Mucolipin 2. (574 aa)
PDE4DPhosphodiesterase. (808 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
SLC25A23Solute carrier family 25 member 23; Belongs to the mitochondrial carrier (TC 2.A.29) family. (468 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (649 aa)
LETM1Leucine zipper and EF-hand containing transmembrane protein 1. (739 aa)
RYR1Ryanodine receptor 1. (4990 aa)
JSRP1Junctional sarcoplasmic reticulum protein 1. (337 aa)
LOC108313439Protein kinase domain-containing protein. (247 aa)
DIAPH1Diaphanous related formin 1. (1206 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1302 aa)
BAXBCL2 associated X, apoptosis regulator. (159 aa)
JPH1Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (661 aa)
LOC108315475C2 domain-containing protein. (141 aa)
CXCL11C-X-C motif chemokine. (94 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
CXCL9C-X-C motif chemokine. (129 aa)
NOL3Nucleolar protein 3. (258 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
SLC8B1Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (584 aa)
LOC108318662Uncharacterized protein. (762 aa)
AKAP6A-kinase anchoring protein 6. (2241 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2996 aa)
LYNTyrosine-protein kinase. (491 aa)
SRISorcin. (198 aa)
BBC3BCL2 binding component 3. (261 aa)
IBTKInhibitor of Bruton tyrosine kinase. (1353 aa)
ANK2Ankyrin 2. (3955 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (990 aa)
FLNAFilamin A. (2192 aa)
JPH4Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (628 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
LOC108294424EF-hand domain-containing protein. (488 aa)
TMEM38ATransmembrane protein 38A. (300 aa)
DMDDystrophin. (3686 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2720 aa)
ENSCCAP00000022396Peptidylprolyl isomerase. (103 aa)
LIME1Uncharacterized protein. (291 aa)
ENSCCAP00000023374Uncharacterized protein; Belongs to the calmodulin family. (200 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2687 aa)
CXCL10C-X-C motif chemokine. (96 aa)
HTTHuntingtin. (3066 aa)
ERO1AEndoplasmic reticulum oxidoreductase 1 alpha. (468 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1299 aa)
BDKRB1Bradykinin receptor B1. (282 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
THY1Thy-1 cell surface antigen. (161 aa)
RYR3Ryanodine receptor 3. (4853 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (816 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (314 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (600 aa)
SELENONEF-hand domain-containing protein. (561 aa)
CHERPCalcium homeostasis endoplasmic reticulum protein. (927 aa)
ENSCCAP00000027698Uncharacterized protein; Belongs to the calmodulin family. (108 aa)
HRCHistidine rich calcium binding protein. (642 aa)
CCL19C-C motif chemokine. (98 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1119 aa)
RASA3RAS p21 protein activator 3. (833 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
METTL21CMethyltransferase like 21C. (264 aa)
JPH2Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (695 aa)
TMEM38BTransmembrane protein 38B. (291 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (939 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (161 aa)
F2RL3F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (385 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (984 aa)
MTLNMitoregulin. (123 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (795 aa)
GSTO1Glutathione S-transferase omega 1. (241 aa)
DHRS7CDehydrogenase/reductase 7C; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
TPCN2Uncharacterized protein. (730 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (884 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1503 aa)
NPSR1Neuropeptide S receptor 1; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (391 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (398 aa)
CCL21C-C motif chemokine ligand 21. (154 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (335 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (281 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2173 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (562 aa)
RYR2Ryanodine receptor 2. (4922 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (839 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (377 aa)
ANXA6Annexin. (673 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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