(53 nodes) Cardiac muscle cell development network (Cebus capucinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NRAP	Nebulin related anchoring protein. (1730 aa)
	BMP10	Bone morphogenetic protein 10. (424 aa)
	ENSCCAP00000010913	SPRY domain-containing protein. (494 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (677 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (479 aa)
	MYO18B	Myosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2551 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	SHOX2	Short stature homeobox 2. (351 aa)
	TBX18	T-box transcription factor 18. (607 aa)
	ALPK3	Alpha kinase 3. (1828 aa)
	SGCD	Sarcoglycan delta. (290 aa)
	BVES	Blood vessel epicardial substance. (360 aa)
	MAML1	Mastermind like transcriptional coactivator 1. (1015 aa)
	MTOR	Serine/threonine-protein kinase mTOR. (2508 aa)
	SORBS2	Sorbin and SH3 domain containing 2. (1198 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
	NKX2-5	NK2 homeobox 5. (324 aa)
	ACTN2	Actinin alpha 2. (895 aa)
	C10orf113	Chromosome 10 open reading frame 113. (106 aa)
	NKX2-6	NK2 homeobox 6. (301 aa)
	ADPRHL1	ADP-ribosylhydrolase like 1. (354 aa)
	SLC8A1	Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (600 aa)
	PLEC	Plectin. (4683 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1108 aa)
	OBSL1	Obscurin like 1. (1896 aa)
	MAP2K4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (410 aa)
	ASB2	Ankyrin repeat and SOCS box containing 2. (635 aa)
	FHOD3	Formin homology 2 domain containing 3. (1623 aa)
	TTN	Uncharacterized protein. (27115 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (432 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	TCAP	Titin-cap. (167 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
	MEF2A	Myocyte enhancer factor 2A. (502 aa)
	ENSCCAP00000039068	PDZ domain-containing protein. (200 aa)
	ALPK2	Alpha kinase 2. (2171 aa)
	MYH11	Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2012 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	TBX3	T-box transcription factor 3. (743 aa)
	PDLIM5	PDZ and LIM domain 5. (625 aa)
	CXADR	CXADR Ig-like cell adhesion molecule. (365 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	LRRC10	Leucine rich repeat containing 10. (279 aa)
	AKAP13	A-kinase anchoring protein 13. (2834 aa)
	ADRA1A	Adrenoceptor alpha 1A. (466 aa)
	LRRC10B	Leucine rich repeat containing 10B. (292 aa)
	SGCB	Sarcoglycan beta. (321 aa)
	NEBL	Nebulette. (977 aa)
	FHL2	Four and a half LIM domains 2. (378 aa)
	GATA4	GATA binding protein 4. (443 aa)
	CSRP3	Cysteine and glycine rich protein 3. (194 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (825 aa)
	SRF	Serum response factor. (509 aa)

Your Current Organism:

Cebus capucinus

NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN2	CSRP3	ENSCCAP00000025117	ENSCCAP00000040167	Actinin alpha 2.	Cysteine and glycine rich protein 3.	0.750
ACTN2	ENSCCAP00000039068	ENSCCAP00000025117	ENSCCAP00000039068	Actinin alpha 2.	PDZ domain-containing protein.	0.441
ACTN2	MYH11	ENSCCAP00000025117	ENSCCAP00000009597	Actinin alpha 2.	Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.418
ACTN2	MYO18B	ENSCCAP00000025117	ENSCCAP00000014358	Actinin alpha 2.	Myosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.405
ACTN2	NEBL	ENSCCAP00000025117	ENSCCAP00000001514	Actinin alpha 2.	Nebulette.	0.418
ACTN2	NRAP	ENSCCAP00000025117	ENSCCAP00000008633	Actinin alpha 2.	Nebulin related anchoring protein.	0.546
ACTN2	OBSL1	ENSCCAP00000025117	ENSCCAP00000027540	Actinin alpha 2.	Obscurin like 1.	0.402
ACTN2	PDLIM5	ENSCCAP00000025117	ENSCCAP00000007726	Actinin alpha 2.	PDZ and LIM domain 5.	0.441
ACTN2	TCAP	ENSCCAP00000025117	ENSCCAP00000035630	Actinin alpha 2.	Titin-cap.	0.785
ACTN2	TTN	ENSCCAP00000025117	ENSCCAP00000033402	Actinin alpha 2.	Uncharacterized protein.	0.858
ALPK3	OBSL1	ENSCCAP00000018114	ENSCCAP00000027540	Alpha kinase 3.	Obscurin like 1.	0.436
ATG5	MTOR	ENSCCAP00000009149	ENSCCAP00000020925	Autophagy protein 5; Involved in autophagic vesicle formation.	Serine/threonine-protein kinase mTOR.	0.556
BMP10	BMPR1A	ENSCCAP00000009780	ENSCCAP00000033496	Bone morphogenetic protein 10.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.633
BMPR1A	BMP10	ENSCCAP00000033496	ENSCCAP00000009780	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 10.	0.633
CAV3	SGCB	ENSCCAP00000024638	ENSCCAP00000002104	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Sarcoglycan beta.	0.481
CAV3	SGCD	ENSCCAP00000024638	ENSCCAP00000019122	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Sarcoglycan delta.	0.603
CSRP3	ACTN2	ENSCCAP00000040167	ENSCCAP00000025117	Cysteine and glycine rich protein 3.	Actinin alpha 2.	0.750
CSRP3	NRAP	ENSCCAP00000040167	ENSCCAP00000008633	Cysteine and glycine rich protein 3.	Nebulin related anchoring protein.	0.690
CSRP3	TCAP	ENSCCAP00000040167	ENSCCAP00000035630	Cysteine and glycine rich protein 3.	Titin-cap.	0.774
CSRP3	TTN	ENSCCAP00000040167	ENSCCAP00000033402	Cysteine and glycine rich protein 3.	Uncharacterized protein.	0.733