(46 nodes) Lung morphogenesis network (Cebus capucinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GRHL2	Grainyhead like transcription factor 2. (625 aa)
	SRF	Serum response factor. (509 aa)
	FOXA1	Forkhead box A1. (470 aa)
	LOC108282374	Uncharacterized protein. (330 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	WNT7B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	NKX2-1	NK2 homeobox 1. (402 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	TBX2	T-box transcription factor 2. (713 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	STK40	Serine/threonine kinase 40. (435 aa)
	TCF21	Transcription factor 21. (179 aa)
	YAP1	Uncharacterized protein. (506 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (464 aa)
	DAG1	Dystroglycan 1. (895 aa)
	CELSR1	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3006 aa)
	NODAL	Nodal growth differentiation factor. (347 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (315 aa)
	LIF	LIF interleukin 6 family cytokine. (202 aa)
	PLOD3	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (742 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	HOXA5	Homeobox A5. (270 aa)
	FGFR2	Fibroblast growth factor receptor. (782 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	HPS1	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. (700 aa)
	HHIP	Hedgehog interacting protein. (700 aa)
	ESRP2	Epithelial splicing regulatory protein 2. (715 aa)
	DSPP	Dentin sialophosphoprotein. (1029 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	MAPK1	Mitogen-activated protein kinase. (366 aa)
	HMGA2	Uncharacterized protein. (118 aa)
	LAMA1	Laminin subunit alpha 1. (3080 aa)
	AP3B1	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1094 aa)
	FOXF1	Forkhead box F1. (378 aa)
	DLG5	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1921 aa)
	CTSZ	Cathepsin Z; Belongs to the peptidase C1 family. (303 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	RSPO2	R-spondin 2. (243 aa)
	SOX9	SRY-box transcription factor 9. (509 aa)
	SOX11	Transcription factor SOX. (450 aa)
	SPRY1	Sprouty RTK signaling antagonist 1. (319 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (1244 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
	CTSH	Cathepsin H; Belongs to the peptidase C1 family. (336 aa)

Your Current Organism:

Cebus capucinus

NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	FGF10	ENSCCAP00000036602	ENSCCAP00000025026	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.520
BMP4	FGF8	ENSCCAP00000036602	ENSCCAP00000021126	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.491
BMP4	FGFR2	ENSCCAP00000036602	ENSCCAP00000022112	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.454
BMP4	FOXF1	ENSCCAP00000036602	ENSCCAP00000012330	Bone morphogenetic protein 4.	Forkhead box F1.	0.578
BMP4	LIF	ENSCCAP00000036602	ENSCCAP00000027539	Bone morphogenetic protein 4.	LIF interleukin 6 family cytokine.	0.509
BMP4	NOG	ENSCCAP00000036602	ENSCCAP00000005156	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.997
BMP4	SHH	ENSCCAP00000036602	ENSCCAP00000032826	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.554
BMP4	TGFBR2	ENSCCAP00000036602	ENSCCAP00000009387	Bone morphogenetic protein 4.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.478
BMP4	WNT2	ENSCCAP00000036602	ENSCCAP00000028165	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.416
CTNNB1	FGF8	ENSCCAP00000015925	ENSCCAP00000021126	Catenin beta 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.437
CTNNB1	FGFR2	ENSCCAP00000015925	ENSCCAP00000022112	Catenin beta 1.	Fibroblast growth factor receptor.	0.557
CTNNB1	HMGA2	ENSCCAP00000015925	ENSCCAP00000014501	Catenin beta 1.	Uncharacterized protein.	0.413
CTNNB1	LOC108282374	ENSCCAP00000015925	ENSCCAP00000037676	Catenin beta 1.	Uncharacterized protein.	0.807
CTNNB1	MAPK1	ENSCCAP00000015925	ENSCCAP00000014631	Catenin beta 1.	Mitogen-activated protein kinase.	0.583
CTNNB1	MAPK3	ENSCCAP00000015925	ENSCCAP00000037321	Catenin beta 1.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.673
CTNNB1	SHH	ENSCCAP00000015925	ENSCCAP00000032826	Catenin beta 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.506
CTNNB1	SOX11	ENSCCAP00000015925	ENSCCAP00000001061	Catenin beta 1.	Transcription factor SOX.	0.545
CTNNB1	SOX9	ENSCCAP00000015925	ENSCCAP00000001761	Catenin beta 1.	SRY-box transcription factor 9.	0.770
CTNNB1	TGFBR2	ENSCCAP00000015925	ENSCCAP00000009387	Catenin beta 1.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.481
CTNNB1	WNT2	ENSCCAP00000015925	ENSCCAP00000028165	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.644