(17 nodes) Kidney mesenchyme development network (Cebus capucinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (464 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	PAX2	Paired box 2. (417 aa)
	TCF21	Transcription factor 21. (179 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (984 aa)
	SMAD4	Mothers against decapentaplegic homolog. (469 aa)
	STAT1	Signal transducer and activator of transcription. (768 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1108 aa)
	AMER1	APC membrane recruitment protein 1. (804 aa)
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	WT1	WT1 transcription factor. (517 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	SIX4	SIX homeobox 4. (781 aa)
	BMP7	Bone morphogenetic protein 7. (430 aa)
	SIX1	SIX homeobox 1. (284 aa)
	SIX2	SIX homeobox 2. (291 aa)
	FOXD1	Forkhead box D1. (468 aa)

Your Current Organism:

Cebus capucinus

NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMER1	WT1	ENSCCAP00000024819	ENSCCAP00000013159	APC membrane recruitment protein 1.	WT1 transcription factor.	0.473
BMP4	BMP7	ENSCCAP00000036602	ENSCCAP00000008930	Bone morphogenetic protein 4.	Bone morphogenetic protein 7.	0.809
BMP4	SHH	ENSCCAP00000036602	ENSCCAP00000032826	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.554
BMP4	SMAD4	ENSCCAP00000036602	ENSCCAP00000030667	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.874
BMP7	BMP4	ENSCCAP00000008930	ENSCCAP00000036602	Bone morphogenetic protein 7.	Bone morphogenetic protein 4.	0.809
BMP7	SHH	ENSCCAP00000008930	ENSCCAP00000032826	Bone morphogenetic protein 7.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.403
BMP7	SMAD4	ENSCCAP00000008930	ENSCCAP00000030667	Bone morphogenetic protein 7.	Mothers against decapentaplegic homolog.	0.462
FOXD1	SMAD4	ENSCCAP00000001020	ENSCCAP00000030667	Forkhead box D1.	Mothers against decapentaplegic homolog.	0.428
FOXD1	WT1	ENSCCAP00000001020	ENSCCAP00000013159	Forkhead box D1.	WT1 transcription factor.	0.401
PAX2	SIX1	ENSCCAP00000035500	ENSCCAP00000007982	Paired box 2.	SIX homeobox 1.	0.574
PAX2	SIX2	ENSCCAP00000035500	ENSCCAP00000007140	Paired box 2.	SIX homeobox 2.	0.572
PAX2	WT1	ENSCCAP00000035500	ENSCCAP00000013159	Paired box 2.	WT1 transcription factor.	0.509
PDGFRB	STAT1	ENSCCAP00000027460	ENSCCAP00000027855	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	Signal transducer and activator of transcription.	0.526
SHH	BMP4	ENSCCAP00000032826	ENSCCAP00000036602	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Bone morphogenetic protein 4.	0.554
SHH	BMP7	ENSCCAP00000032826	ENSCCAP00000008930	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Bone morphogenetic protein 7.	0.403
SIX1	PAX2	ENSCCAP00000007982	ENSCCAP00000035500	SIX homeobox 1.	Paired box 2.	0.574
SIX2	PAX2	ENSCCAP00000007140	ENSCCAP00000035500	SIX homeobox 2.	Paired box 2.	0.572
SIX2	WT1	ENSCCAP00000007140	ENSCCAP00000013159	SIX homeobox 2.	WT1 transcription factor.	0.509
SMAD4	BMP4	ENSCCAP00000030667	ENSCCAP00000036602	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 4.	0.874
SMAD4	BMP7	ENSCCAP00000030667	ENSCCAP00000008930	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 7.	0.462