STRINGSTRING
KDM1A KDM1A HNRNPU HNRNPU WNT11 WNT11 SOX11 SOX11 ZFP36L1 ZFP36L1 NFIB NFIB SOX9 SOX9 ELL3 ELL3 FERMT1 FERMT1 KDF1 KDF1 SFN SFN PRRX1 PRRX1 ATXN1L ATXN1L CCNE1 CCNE1 CDKN2C CDKN2C IRF6 IRF6 OVOL1 OVOL1 FGF9 FGF9 TBX3 TBX3 PTCH1 PTCH1 SIRT6 SIRT6 EPCAM EPCAM ENSCCAP00000008780 ENSCCAP00000008780 IRS2 IRS2 ACE ACE FERMT2 FERMT2 TGFBR2 TGFBR2 VEGFC VEGFC ENSCCAP00000010913 ENSCCAP00000010913 HOXA3 HOXA3 FGF4 FGF4 KAT7 KAT7 SNAI2 SNAI2 HMGA2 HMGA2 FBLN1 FBLN1 CTNNB1 CTNNB1 SHOX2 SHOX2 ID4 ID4 WNT5A WNT5A KITLG KITLG TP63 TP63 PDCD2 PDCD2 KDR KDR NF1 NF1 CD109 CD109 HMX2 HMX2 LOC108317287 LOC108317287 RARG RARG FGF8 FGF8 OVOL2 OVOL2 PIM1 PIM1 PTPRC PTPRC GLI3 GLI3 LTBP3 LTBP3 FGF10 FGF10 THPO THPO TERT TERT TGFB1 TGFB1 WNT1 WNT1 EIF2AK2 EIF2AK2 RARB RARB ENSCCAP00000039573 ENSCCAP00000039573 WNT10B WNT10B LOC108282374 LOC108282374 N4BP2L2 N4BP2L2 DGCR8 DGCR8 NF2 NF2 CITED1 CITED1 SOX18 SOX18 YAP1 YAP1 OSR2 OSR2 NOTCH1 NOTCH1 SHH SHH AGO3 AGO3 SOX17 SOX17 NR2E1 NR2E1 TP53 TP53 TIAL1 TIAL1 RUNX2 RUNX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (825 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SOX11Transcription factor SOX. (450 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
SOX9SRY-box transcription factor 9. (509 aa)
ELL3Elongation factor for RNA polymerase II 3. (432 aa)
FERMT1Fermitin family member 1. (378 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
PRRX1Paired related homeobox 1. (245 aa)
ATXN1LAtaxin 1 like. (689 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
IRF6Interferon regulatory factor 6. (467 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TBX3T-box transcription factor 3. (743 aa)
PTCH1Patched 1. (1452 aa)
SIRT6Sirtuin 6. (382 aa)
EPCAMEpithelial cell adhesion molecule. (239 aa)
ENSCCAP00000008780Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
IRS2Insulin receptor substrate 2. (1361 aa)
ACEAngiotensin-converting enzyme. (1308 aa)
FERMT2Fermitin family member 2. (693 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
ENSCCAP00000010913SPRY domain-containing protein. (494 aa)
HOXA3Homeobox A3. (444 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (534 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
HMGA2Uncharacterized protein. (118 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (715 aa)
CTNNB1Catenin beta 1. (781 aa)
SHOX2Short stature homeobox 2. (351 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (268 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
PDCD2Programmed cell death 2. (343 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
NF1Neurofibromin 1. (2839 aa)
CD109CD109 molecule. (1445 aa)
HMX2H6 family homeobox 2. (273 aa)
LOC108317287Uncharacterized protein. (368 aa)
RARGRetinoic acid receptor gamma. (456 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
OVOL2Ovo like zinc finger 2. (275 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1299 aa)
GLI3GLI family zinc finger 3. (1577 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1300 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
THPOThrombopoietin. (335 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1121 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (314 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (527 aa)
RARBRetinoic acid receptor beta. (448 aa)
ENSCCAP00000039573Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (592 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
LOC108282374Uncharacterized protein. (330 aa)
N4BP2L2NEDD4 binding protein 2 like 2. (750 aa)
DGCR8DGCR8 microprocessor complex subunit. (773 aa)
NF2Neurofibromin 2. (595 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (220 aa)
SOX18SRY-box transcription factor 18. (380 aa)
YAP1Uncharacterized protein. (506 aa)
OSR2Odd-skipped related transciption factor 2. (417 aa)
NOTCH1Notch receptor 1. (2550 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (464 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
SOX17SRY-box transcription factor 17. (408 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (421 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (395 aa)
TIAL1Uncharacterized protein. (355 aa)
RUNX2RUNX family transcription factor 2. (540 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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