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| | APEX1 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa) |
| | CECR2 | CECR2 histone acetyl-lysine reader. (1431 aa) |
| | CHRAC1 | CBFD_NFYB_HMF domain-containing protein. (131 aa) |
| | HFM1 | Helicase for meiosis 1. (1433 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | RAD51C | RECA_2 domain-containing protein. (352 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (708 aa) |
| | ENSCCAP00000030953 | Uncharacterized protein. (583 aa) |
| | N6AMT1 | N-6 adenine-specific DNA methyltransferase 1. (214 aa) |
| | ENSCCAP00000031543 | CIDE-N domain-containing protein. (156 aa) |
| | SUPV3L1 | Suv3 like RNA helicase. (766 aa) |
| | MSH5 | DNA_MISMATCH_REPAIR_2 domain-containing protein. (833 aa) |
| | PMS2 | PMS1 homolog 2, mismatch repair system component. (862 aa) |
| | LOC108312138 | Uncharacterized protein. (546 aa) |
| | ENSCCAP00000033006 | UDG domain-containing protein. (282 aa) |
| | LOC108312238 | Nucleoside diphosphate kinase. (143 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (835 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | MSH4 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (870 aa) |
| | DNMT1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1628 aa) |
| | CHD3 | Chromodomain helicase DNA binding protein 3. (2059 aa) |
| | POLM | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (494 aa) |
| | C17orf64 | Chromosome 17 open reading frame 64. (236 aa) |
| | REXO2 | RNA exonuclease 2. (237 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | TM4SF19 | Uncharacterized protein. (208 aa) |
| | DHX36 | DEAH-box helicase 36. (1001 aa) |
| | ENDOV | Endonuclease V. (282 aa) |
| | TENT4B | Terminal nucleotidyltransferase 4B. (695 aa) |
| | CHD2 | Uncharacterized protein. (1827 aa) |
| | TEP1 | Telomerase associated protein 1. (2623 aa) |
| | DNASE1L2 | Deoxyribonuclease; Belongs to the DNase I family. (299 aa) |
| | LOC108303592 | SAP domain-containing protein. (507 aa) |
| | RECQL4 | RecQ like helicase 4. (1211 aa) |
| | DNASE2 | Deoxyribonuclease 2, lysosomal. (233 aa) |
| | SMUG1 | Uncharacterized protein. (270 aa) |
| | TATDN1 | TatD DNase domain containing 1. (297 aa) |
| | EP400 | E1A binding protein p400. (3118 aa) |
| | CHD1L | Chromodomain helicase DNA binding protein 1 like. (867 aa) |
| | CHD9 | Chromodomain helicase DNA binding protein 9. (2882 aa) |
| | RAD9B | RAD9 checkpoint clamp component B. (345 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (534 aa) |
| | MGMT | O-6-methylguanine-DNA methyltransferase. (238 aa) |
| | ENSCCAP00000037775 | BAH domain-containing protein. (518 aa) |
| | OGG1 | 8-oxoguanine DNA glycosylase. (402 aa) |
| | HELQ | Helicase, POLQ like. (1100 aa) |
| | APTX | Aprataxin. (343 aa) |
| | CHD6 | Chromodomain helicase DNA binding protein 6. (2716 aa) |
| | ALKBH3 | AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase. (285 aa) |
| | POLI | DNA polymerase iota. (738 aa) |
| | DNTT | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (509 aa) |
| | ALKBH1 | AlkB homolog 1, histone H2A dioxygenase. (389 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (709 aa) |
| | HAUS3 | HAUS augmin like complex subunit 3. (603 aa) |
| | DNMT3A | DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa) |
| | LOC108314810 | SAP domain-containing protein. (545 aa) |
| | ARID3A | AT-rich interaction domain 3A. (594 aa) |
| | POLH | DNA polymerase eta. (710 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (713 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1139 aa) |
| | ENSCCAP00000040243 | Ku domain-containing protein. (527 aa) |
| | RFC3 | Replication factor C subunit 3. (236 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa) |
| | DNASE1L1 | Deoxyribonuclease; Belongs to the DNase I family. (302 aa) |
| | ENSCCAP00000000393 | Uncharacterized protein. (145 aa) |
| | LIG3 | DNA ligase. (1014 aa) |
| | POLG | DNA polymerase gamma, catalytic subunit. (1230 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa) |
| | ZRANB3 | Zinc finger RANBP2-type containing 3. (1080 aa) |
| | MYO18A | Myosin XVIIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2054 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (709 aa) |
| | ENSCCAP00000002395 | Uncharacterized protein. (92 aa) |
| | CHD4 | Uncharacterized protein. (1912 aa) |
| | LOC108311244 | Nucleoside diphosphate kinase. (146 aa) |
| | ENSCCAP00000002896 | Uncharacterized protein. (240 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (904 aa) |
| | NEIL3 | Nei like DNA glycosylase 3. (606 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (899 aa) |
| | ANKLE1 | Ankyrin repeat and LEM domain containing 1. (665 aa) |
| | LOC108308846 | Uncharacterized protein. (235 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | ENSCCAP00000004458 | Uncharacterized protein. (113 aa) |
| | RFC1 | Replication factor C subunit 1. (1122 aa) |
| | TDG | Thymine DNA glycosylase. (410 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | MLH1 | MutL homolog 1. (757 aa) |
| | METTL4 | Methyltransferase like 4; Belongs to the MT-A70-like family. (448 aa) |
| | ENSCCAP00000005186 | Uncharacterized protein. (110 aa) |
| | ALKBH2 | AlkB homolog 2, alpha-ketoglutarate dependent dioxygenase. (261 aa) |
| | DNMT3B | Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (853 aa) |
| | ENSCCAP00000005315 | UmuC domain-containing protein. (176 aa) |
| | ENSCCAP00000005370 | Uncharacterized protein. (97 aa) |
| | ERCC2 | ERCC excision repair 2, TFIIH core complex helicase subunit. (770 aa) |
| | CHD8 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2589 aa) |
| | PGBD5 | PiggyBac transposable element derived 5. (524 aa) |
| | C11orf80 | Chromosome 11 open reading frame 80. (578 aa) |
| | NEIL1 | Nei like DNA glycosylase 1. (390 aa) |
| | GTF2F2 | General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (552 aa) |
| | TOP3B | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (726 aa) |
| | LOC108300644 | KH type-2 domain-containing protein. (261 aa) |
| | LOC108306844 | Uncharacterized protein. (540 aa) |
| | MPG | N-methylpurine DNA glycosylase. (279 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (644 aa) |
| | EXO1 | Exonuclease 1. (847 aa) |
| | APLF | Aprataxin and PNKP like factor. (502 aa) |
| | LOC108284825 | Uncharacterized protein. (204 aa) |
| | SHPRH | SNF2 histone linker PHD RING helicase. (1684 aa) |
| | RPS3 | Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (270 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (311 aa) |
| | RAD51D | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (328 aa) |
| | NTHL1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (312 aa) |
| | SMARCAD1 | Uncharacterized protein. (1026 aa) |
| | TWNK | Twinkle mtDNA helicase. (684 aa) |
| | SETMAR | SET domain and mariner transposase fusion gene. (684 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | LIG1 | DNA ligase. (919 aa) |
| | SPO11 | SPO11 initiator of meiotic double stranded breaks. (396 aa) |
| | RAD51B | RAD51 paralog B. (426 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1060 aa) |
| | DHX9 | DExH-box helicase 9. (1136 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (119 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (957 aa) |
| | ENSCCAP00000009946 | PWWP domain-containing protein. (368 aa) |
| | TDP2 | Tyrosyl-DNA phosphodiesterase 2. (362 aa) |
| | MSH3 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1124 aa) |
| | EXOG | Exo/endonuclease G. (368 aa) |
| | BLM | BLM RecQ like helicase. (1401 aa) |
| | ENSCCAP00000010734 | Uncharacterized protein; Belongs to the universal ribosomal protein uS3 family. (216 aa) |
| | POLA1 | DNA polymerase. (1391 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1686 aa) |
| | FBH1 | F-box DNA helicase 1. (1080 aa) |
| | NAV2 | Neuron navigator 2. (2487 aa) |
| | PLD4 | Phospholipase D family member 4. (506 aa) |
| | LOC108299224 | Uncharacterized protein. (106 aa) |
| | ERCC6L | ERCC excision repair 6 like, spindle assembly checkpoint helicase. (1254 aa) |
| | WRN | WRN RecQ like helicase. (1431 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (345 aa) |
| | HELB | DNA helicase B. (1086 aa) |
| | ASCC3 | Activating signal cointegrator 1 complex subunit 3. (2202 aa) |
| | HMGA1 | High mobility group AT-hook 1. (107 aa) |
| | LOC108317875 | RECA_2 domain-containing protein. (351 aa) |
| | ERCC3 | ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa) |
| | RAD54L2 | RAD54 like 2. (1274 aa) |
| | DNASE1L3 | Deoxyribonuclease; Belongs to the DNase I family. (305 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | DCLRE1B | DNA cross-link repair 1B. (540 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1212 aa) |
| | MUTYH | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (550 aa) |
| | ENSCCAP00000014053 | DNA_pol_B domain-containing protein. (262 aa) |
| | CHD5 | Chromodomain helicase DNA binding protein 5. (1954 aa) |
| | DDX11 | DEAD/H-box helicase 11. (957 aa) |
| | HMGA2 | Uncharacterized protein. (118 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | MEIOB | Meiosis specific with OB-fold. (455 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1498 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (468 aa) |
| | ENSCCAP00000015049 | Uncharacterized protein. (568 aa) |
| | PMS1 | PMS1 homolog 1, mismatch repair system component. (930 aa) |
| | ISG20 | Interferon stimulated exonuclease gene 20. (181 aa) |
| | ATRX | ATRX chromatin remodeler. (2240 aa) |
| | LOC108291481 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (465 aa) |
| | PRIMPOL | Uncharacterized protein. (454 aa) |
| | NEIL2 | Nei like DNA glycosylase 2. (326 aa) |
| | POLG2 | DNA polymerase gamma 2, accessory subunit. (485 aa) |
| | RAD54L | RAD54 like. (747 aa) |
| | CHD7 | Chromodomain helicase DNA binding protein 7. (2996 aa) |
| | ZGRF1 | Zinc finger GRF-type containing 1. (2064 aa) |
| | TOP2A | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa) |
| | FTO | FTO alpha-ketoglutarate dependent dioxygenase. (505 aa) |
| | CEP41 | Centrosomal protein 41. (373 aa) |
| | POLN | DNA polymerase nu. (879 aa) |
| | POLQ | DNA polymerase theta. (2324 aa) |
| | FANCM | FA complementation group M. (1992 aa) |
| | HELLS | Helicase, lymphoid specific. (471 aa) |
| | ERCC6L2 | ERCC excision repair 6 like 2. (712 aa) |
| | DNASE1 | Deoxyribonuclease; Belongs to the DNase I family. (282 aa) |
| | MCM8 | MCM domain-containing protein; Belongs to the MCM family. (850 aa) |
| | HLTF | Helicase like transcription factor. (1009 aa) |
| | DICER1 | Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1922 aa) |
| | IGHMBP2 | Immunoglobulin mu DNA binding protein 2. (993 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (785 aa) |
| | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa) |
| | DKC1 | Dyskerin pseudouridine synthase 1. (470 aa) |
| | SMC6 | Structural maintenance of chromosomes 6. (1097 aa) |
| | BTAF1 | B-TFIID TATA-box binding protein associated factor 1. (1849 aa) |
| | MGME1 | Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (343 aa) |
| | LOC108297905 | Uncharacterized protein. (791 aa) |
| | SRCAP | Uncharacterized protein. (3217 aa) |
| | RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (649 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1345 aa) |
| | ENDOG | Endonuclease. (285 aa) |
| | MPHOSPH9 | M-phase phosphoprotein 9. (991 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1016 aa) |
| | MLH3 | MutL homolog 3. (1456 aa) |
| | LOC108292630 | EP400_N domain-containing protein. (441 aa) |
| | G3BP1 | G3BP stress granule assembly factor 1. (466 aa) |
| | DCLRE1A | DRMBL domain-containing protein. (1040 aa) |
| | POLK | DNA polymerase kappa. (863 aa) |
| | RSF1 | Remodeling and spacing factor 1. (1437 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (2752 aa) |
| | UNG | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (313 aa) |
| | CHD1 | Chromodomain helicase DNA binding protein 1. (1674 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (282 aa) |
| | CDK7 | Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa) |
| | MBD4 | Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (579 aa) |
| | TOP2B | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1619 aa) |
| | TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (767 aa) |
| | LOC108311527 | Uncharacterized protein. (631 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa) |
| | DDX1 | DEAD-box helicase 1. (740 aa) |
| | SETX | Senataxin. (2678 aa) |
| | TDP1 | Tyrosyl-DNA phosphodiesterase 1. (606 aa) |
| | XRCC6 | SAP domain-containing protein. (534 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | INO80 | INO80 complex ATPase subunit. (1556 aa) |
| | WRNIP1 | WRN helicase interacting protein 1. (666 aa) |
| | PLD3 | Phospholipase D family member 3. (490 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1121 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (280 aa) |
| | DNASE2B | Deoxyribonuclease 2 beta. (361 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (907 aa) |
| | SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1049 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (391 aa) |
| | POLD1 | DNA polymerase. (1105 aa) |
| | DQX1 | DEAQ-box RNA dependent ATPase 1. (726 aa) |
| | SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1588 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (990 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa) |
| | ALKBH4 | AlkB homolog 4, lysine demethylase. (309 aa) |
| | LOC108288088 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (305 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1151 aa) |
| | SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1642 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1289 aa) |
| | TTF2 | Transcription termination factor 2. (1163 aa) |
