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| | ENSCCAP00000031489 | HTH myb-type domain-containing protein. (287 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa) |
| | SKA3 | Spindle and kinetochore associated complex subunit 3. (390 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | LOC108299438 | G-patch domain-containing protein. (331 aa) |
| | CENPN | Centromere protein N. (336 aa) |
| | ENSCCAP00000014200 | Uncharacterized protein. (88 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2437 aa) |
| | TERF2IP | TERF2 interacting protein. (399 aa) |
| | KMT5C | Lysine methyltransferase 5C. (463 aa) |
| | DCLRE1B | DNA cross-link repair 1B. (540 aa) |
| | SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1. (1085 aa) |
| | CBX5 | Chromobox 5. (191 aa) |
| | NCAPD3 | Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. (1498 aa) |
| | NRG3 | Neuregulin 3. (719 aa) |
| | LOC108294831 | MAGE domain-containing protein. (406 aa) |
| | ENSCCAP00000012593 | Uncharacterized protein. (154 aa) |
| | ZBTB48 | Zinc finger and BTB domain containing 48. (687 aa) |
| | TERB1 | Telomere repeat binding bouquet formation protein 1. (695 aa) |
| | ITGB3BP | Integrin subunit beta 3 binding protein. (215 aa) |
| | WRN | WRN RecQ like helicase. (1431 aa) |
| | CENPK | Centromere protein K. (251 aa) |
| | SGO1 | Shugoshin 1. (522 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (547 aa) |
| | ACD | ACD shelterin complex subunit and telomerase recruitment factor. (509 aa) |
| | MTBP | MDM2 binding protein. (904 aa) |
| | TEN1 | Uncharacterized protein. (123 aa) |
| | LRWD1 | Leucine rich repeats and WD repeat domain containing 1. (647 aa) |
| | IKZF1 | IKAROS family zinc finger 1. (575 aa) |
| | ENSCCAP00000009828 | Uncharacterized protein. (84 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (376 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1060 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | CENPU | Centromere protein U. (419 aa) |
| | ENSCCAP00000008966 | Uncharacterized protein. (183 aa) |
| | CENPE | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2584 aa) |
| | ENSCCAP00000008837 | Uncharacterized protein. (60 aa) |
| | SPC25 | SPC25 component of NDC80 kinetochore complex. (224 aa) |
| | SIRT6 | Sirtuin 6. (382 aa) |
| | ZWINT | ZW10 interacting kinetochore protein. (289 aa) |
| | KNTC1 | Kinetochore associated 1. (2181 aa) |
| | LOC108282446 | CS domain-containing protein. (127 aa) |
| | MEAF6 | MYST/Esa1 associated factor 6. (201 aa) |
| | SKA2 | Spindle and kinetochore associated complex subunit 2. (121 aa) |
| | BOD1L1 | Biorientation of chromosomes in cell division 1 like 1. (3004 aa) |
| | ZNF618 | Zinc finger protein 618. (954 aa) |
| | ENSCCAP00000005880 | MAGE domain-containing protein. (406 aa) |
| | ZW10 | Zw10 kinetochore protein. (779 aa) |
| | TNKS | Poly [ADP-ribose] polymerase. (1325 aa) |
| | BIRC5 | Uncharacterized protein. (74 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa) |
| | NDE1 | NudE neurodevelopment protein 1. (346 aa) |
| | SYCP3 | Cor1 domain-containing protein. (236 aa) |
| | RCC2 | Regulator of chromosome condensation 2. (522 aa) |
| | LOC108281839 | Uncharacterized protein. (142 aa) |
| | CHAMP1 | Chromosome alignment maintaining phosphoprotein 1. (813 aa) |
| | FBXO28 | F-box protein 28. (369 aa) |
| | KNSTRN | Kinetochore localized astrin (SPAG5) binding protein. (316 aa) |
| | ENSCCAP00000004458 | Uncharacterized protein. (113 aa) |
| | FAM43B | Family with sequence similarity 43 member B. (329 aa) |
| | CTC1 | CST telomere replication complex component 1. (1162 aa) |
| | MIS12 | MIS12 kinetochore complex component. (205 aa) |
| | RSKR | Ribosomal protein S6 kinase related. (404 aa) |
| | UHRF2 | Ubiquitin like with PHD and ring finger domains 2. (802 aa) |
| | ENSCCAP00000002395 | Uncharacterized protein. (92 aa) |
| | FAM43A | Family with sequence similarity 43 member A. (419 aa) |
| | SIM1 | SIM bHLH transcription factor 1. (778 aa) |
| | SKA1 | Spindle and kinetochore associated complex subunit 1. (255 aa) |
| | CENPB | Centromere protein B. (601 aa) |
| | LOC108307733 | Uncharacterized protein. (186 aa) |
| | MACROH2A1 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (371 aa) |
| | ENSCCAP00000000954 | Uncharacterized protein. (153 aa) |
| | KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa) |
| | ZNF276 | Zinc finger protein 276. (616 aa) |
| | BOD1L2 | Biorientation of chromosomes in cell division 1 like 2. (177 aa) |
| | SUGT1 | SGT1 homolog, MIS12 kinetochore complex assembly cochaperone. (365 aa) |
| | CTCF | CCCTC-binding factor. (676 aa) |
| | CENPQ | Centromere protein Q. (269 aa) |
| | MKI67 | Marker of proliferation Ki-67. (3258 aa) |
| | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase. (1066 aa) |
| | WRAP53 | WD repeat containing antisense to TP53. (549 aa) |
| | PHF2 | PHD finger protein 2. (1102 aa) |
| | CENPC | Centromere protein C. (945 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (708 aa) |
| | CENPA | Centromere protein A. (138 aa) |
| | MIS18BP1 | MIS18 binding protein 1. (1135 aa) |
| | KNL1 | Kinetochore scaffold 1. (2183 aa) |
| | ENSCCAP00000029288 | Uncharacterized protein. (49 aa) |
| | NDC80 | NDC80 kinetochore complex component. (642 aa) |
| | GPATCH11 | G-patch domain containing 11. (285 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1151 aa) |
| | ENSCCAP00000028238 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (422 aa) |
| | PINX1 | G-patch domain-containing protein. (327 aa) |
| | KIF22 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (666 aa) |
| | CENPT | Centromere protein T. (561 aa) |
| | BOD1 | Uncharacterized protein. (185 aa) |
| | KIF2C | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (725 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1121 aa) |
| | TTK | TTK protein kinase. (856 aa) |
| | TERB2 | Telomere repeat binding bouquet formation protein 2. (221 aa) |
| | GLYATL3 | Glycine-N-acyltransferase like 3. (288 aa) |
| | NEK2 | NIMA related kinase 2. (445 aa) |
| | CKAP5 | Cytoskeleton associated protein 5. (2032 aa) |
| | SNAI1 | Snail family transcriptional repressor 1. (264 aa) |
| | ZNF827 | Zinc finger protein 827. (1084 aa) |
| | HSF1 | Heat shock transcription factor 1. (532 aa) |
| | ZNF330 | Zinc finger protein 330. (320 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4130 aa) |
| | F2 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa) |
| | PTGES3 | CS domain-containing protein. (106 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1345 aa) |
| | CBX3 | Uncharacterized protein. (183 aa) |
| | PPP1R12A | Protein phosphatase 1 regulatory subunit. (1030 aa) |
| | DYNC1I1 | Dynein cytoplasmic 1 intermediate chain 1. (645 aa) |
| | NSL1 | NSL1 component of MIS12 kinetochore complex. (281 aa) |
| | ZWILCH | Zwilch kinetochore protein. (594 aa) |
| | SMC5 | SMC_N domain-containing protein. (1102 aa) |
| | PDS5B | PDS5 cohesin associated factor B. (1447 aa) |
| | TNKS2 | Poly [ADP-ribose] polymerase. (1166 aa) |
| | MDP1 | Magnesium dependent phosphatase 1. (164 aa) |
| | MEIKIN | Meiotic kinetochore factor. (346 aa) |
| | CHMP5 | Uncharacterized protein. (219 aa) |
| | CENPO | Centromere protein O. (300 aa) |
| | HELLS | Helicase, lymphoid specific. (471 aa) |
| | BUB1B | BUB1 N-terminal domain-containing protein. (1039 aa) |
| | DSN1 | DSN1 component of MIS12 kinetochore complex. (354 aa) |
| | LOC108287552 | Cor1 domain-containing protein. (217 aa) |
| | ZSCAN4 | Zinc finger and SCAN domain containing 4. (433 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (484 aa) |
| | WDSUB1 | WD repeat, sterile alpha motif and U-box domain containing 1. (476 aa) |
| | SIM2 | SIM bHLH transcription factor 2. (668 aa) |
| | CENPF | Centromere protein F. (3116 aa) |
| | PMF1 | Polyamine modulated factor 1. (205 aa) |
| | SPC24 | SPC24 component of NDC80 kinetochore complex. (223 aa) |
| | ENSCCAP00000015706 | Uncharacterized protein. (131 aa) |
| | CENPI | Centromere protein I. (658 aa) |
| | DYNC1LI1 | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (523 aa) |
| | ATRX | ATRX chromatin remodeler. (2240 aa) |
| | ENSCCAP00000015138 | TRF domain-containing protein. (250 aa) |
| | DMRT2 | Doublesex and mab-3 related transcription factor 2. (562 aa) |
| | CBX1 | Chromobox 1. (256 aa) |
| | LOC108290165 | Uncharacterized protein. (600 aa) |
| | POT1 | Protection of telomeres 1. (666 aa) |
| | TINF2 | TERF1 interacting nuclear factor 2. (447 aa) |
| | DHX36 | DEAH-box helicase 36. (1001 aa) |
| | ANAPC16 | Uncharacterized protein. (152 aa) |
| | CENPV | Centromere protein V. (270 aa) |
| | ENSCCAP00000034472 | Chromo domain-containing protein. (151 aa) |
| | ENSCCAP00000034455 | G-patch domain-containing protein. (291 aa) |
| | ZBTB10 | Zinc finger and BTB domain containing 10. (867 aa) |
| | ENSCCAP00000034051 | Uncharacterized protein. (139 aa) |
| | SS18L1 | SS18L1 subunit of BAF chromatin remodeling complex. (396 aa) |
| | TPR | Translocated promoter region, nuclear basket protein. (2366 aa) |
| | RASSF2 | Ras association domain family member 2. (326 aa) |
| | ICE2 | Interactor of little elongation complex ELL subunit 2. (953 aa) |
| | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa) |
| | WAPL | WAPL cohesin release factor. (1191 aa) |
| | NSMCE4A | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (385 aa) |
| | XPO1 | Exportin 1. (928 aa) |
| | SAPCD1 | Suppressor APC domain containing 1. (178 aa) |
| | CENPS | Centromere protein S. (138 aa) |
| | CEBPZ | CCAAT enhancer binding protein zeta. (1054 aa) |
| | TERF2 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (527 aa) |
| | NSMCE1 | NSE1 homolog, SMC5-SMC6 complex component. (266 aa) |
| | NUF2 | NUF2 component of NDC80 kinetochore complex. (464 aa) |
| | HJURP | Holliday junction recognition protein. (744 aa) |
| | SPAG5 | Sperm associated antigen 5. (1193 aa) |
| | CENPW | Centromere protein W. (88 aa) |
| | RECQL4 | RecQ like helicase 4. (1211 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
