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| | PNP | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa) |
| | SLC25A42 | Solute carrier family 25 member 42; Belongs to the mitochondrial carrier (TC 2.A.29) family. (318 aa) |
| | AK8 | Adenylate kinase 8; Belongs to the adenylate kinase family. (441 aa) |
| | AK9 | Adenylate kinase 9. (1905 aa) |
| | LOC108284106 | IQCJ-SCHIP1 readthrough. (491 aa) |
| | ENSCCAP00000020701 | Uncharacterized protein. (145 aa) |
| | NUDT6 | Nudix hydrolase 6; Belongs to the Nudix hydrolase family. (316 aa) |
| | AK4 | Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa) |
| | ENTPD5 | Ectonucleoside triphosphate diphosphohydrolase 5 (inactive); Belongs to the GDA1/CD39 NTPase family. (427 aa) |
| | ENTPD2 | Ectonucleoside triphosphate diphosphohydrolase 2; Belongs to the GDA1/CD39 NTPase family. (495 aa) |
| | NT5C3A | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (336 aa) |
| | PAPOLG | Poly(A) polymerase gamma. (736 aa) |
| | TXNRD1 | Thioredoxin reductase 1. (648 aa) |
| | NT5C2 | 5'-nucleotidase, cytosolic II. (558 aa) |
| | TXNDC2 | Thioredoxin domain-containing protein. (323 aa) |
| | NUDT16L1 | Nudix hydrolase 16 like 1. (245 aa) |
| | AK7 | Adenylate kinase 7. (675 aa) |
| | ENSCCAP00000016083 | GMP_synt_C domain-containing protein. (198 aa) |
| | CEP44 | Centrosomal protein 44. (387 aa) |
| | DCTPP1 | dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. (170 aa) |
| | LOC108299138 | Uncharacterized protein. (123 aa) |
| | ENTPD3 | Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (529 aa) |
| | TK2 | dNK domain-containing protein. (307 aa) |
| | NT5DC1 | 5'-nucleotidase domain containing 1. (455 aa) |
| | SETBP1 | SET binding protein 1. (1596 aa) |
| | LOC108308844 | ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (231 aa) |
| | ADPRM | ADP-ribose/CDP-alcohol diphosphatase, manganese dependent. (345 aa) |
| | UPB1 | Beta-ureidopropionase 1. (401 aa) |
| | UCKL1 | Uridine-cytidine kinase; Belongs to the uridine kinase family. (547 aa) |
| | DTYMK | Deoxythymidylate kinase. (212 aa) |
| | NRSN1 | Neurensin 1. (195 aa) |
| | CTPS2 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (373 aa) |
| | DPYD | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (996 aa) |
| | GSR | Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (522 aa) |
| | PUDP | Uncharacterized protein. (202 aa) |
| | MARVELD1 | MARVEL domain containing 1. (173 aa) |
| | ENTPD6 | Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (482 aa) |
| | RRM2 | Uncharacterized protein. (472 aa) |
| | NME8 | NME/NM23 family member 8. (592 aa) |
| | ENSCCAP00000001652 | Thioredoxin domain-containing protein. (91 aa) |
| | LOC108306195 | MGS domain-containing protein. (593 aa) |
| | ENSCCAP00000001938 | Uncharacterized protein. (419 aa) |
| | TXNDC8 | Thioredoxin domain containing 8. (127 aa) |
| | CMPK1 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (228 aa) |
| | NME2 | Nucleoside diphosphate kinase. (152 aa) |
| | LOC108311244 | Nucleoside diphosphate kinase. (146 aa) |
| | ENSCCAP00000002956 | dNK domain-containing protein. (254 aa) |
| | ENSCCAP00000012572 | Uncharacterized protein. (137 aa) |
| | DCK | Deoxycytidine kinase. (317 aa) |
| | ADK | Adenosine kinase. (362 aa) |
| | UCK2 | Uridine-cytidine kinase; Belongs to the uridine kinase family. (261 aa) |
| | TK1 | Thymidine kinase. (234 aa) |
| | PPAT | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (514 aa) |
| | TXNRD3 | Thioredoxin reductase 3. (641 aa) |
| | ITPA | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (207 aa) |
| | AGXT2 | Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (481 aa) |
| | ADSS1 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (457 aa) |
| | ATIC | MGS domain-containing protein. (557 aa) |
| | GART | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (874 aa) |
| | ENTPD4 | Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (616 aa) |
| | RRM2B | Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (351 aa) |
| | IPO13 | Importin 13. (963 aa) |
| | NT5E | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa) |
| | NME9 | NME/NM23 family member 9; Belongs to the NDK family. (329 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (509 aa) |
| | GMPR | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa) |
| | NUDT16 | Nudix hydrolase 16. (219 aa) |
| | DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. (207 aa) |
| | AK6 | Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (172 aa) |
| | IMPDH1 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (626 aa) |
| | ENSCCAP00000006951 | Uncharacterized protein; Belongs to the adenylate kinase family. (186 aa) |
| | AMPD1 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (775 aa) |
| | UPP2 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (365 aa) |
| | NT5C1B | Uncharacterized protein. (602 aa) |
| | RRM1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa) |
| | ENSCCAP00000005485 | Uncharacterized protein. (168 aa) |
| | NT5C1A | 5'-nucleotidase, cytosolic IA. (371 aa) |
| | ENSCCAP00000005127 | A_deaminase domain-containing protein. (260 aa) |
| | ENSCCAP00000004993 | Nudix hydrolase domain-containing protein; Belongs to the Nudix hydrolase family. (193 aa) |
| | ADSS2 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa) |
| | TXN | Thioredoxin; Belongs to the thioredoxin family. (105 aa) |
| | ADSL | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (498 aa) |
| | LOC108294705 | Thymidylat_synt domain-containing protein. (302 aa) |
| | SMIM3 | Small integral membrane protein 3. (60 aa) |
| | CTPS1 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (591 aa) |
| | UPP1 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (310 aa) |
| | PFAS | Phosphoribosylformylglycinamidine synthase. (1276 aa) |
| | AMPD2 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (880 aa) |
| | LOC108292926 | MGS domain-containing protein. (536 aa) |
| | UCK1 | Uridine-cytidine kinase; Belongs to the uridine kinase family. (302 aa) |
| | CDA | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa) |
| | NUDT5 | Nudix hydrolase domain-containing protein; Belongs to the Nudix hydrolase family. (230 aa) |
| | NUDT9 | Nudix hydrolase 9. (350 aa) |
| | ADAL | Adenosine deaminase like. (355 aa) |
| | AK2 | ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (201 aa) |
| | ADA | A_deaminase domain-containing protein. (363 aa) |
| | AMPD3 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (777 aa) |
| | NT5C | 5', 3'-nucleotidase, cytosolic. (201 aa) |
| | DCTD | dCMP deaminase. (244 aa) |
| | IQCJ | IQ motif containing J. (132 aa) |
| | GMPS | Uncharacterized protein. (693 aa) |
| | ENTPD7 | Ectonucleoside triphosphate diphosphohydrolase 7; Belongs to the GDA1/CD39 NTPase family. (605 aa) |
| | DPYS | Dihydropyrimidinase. (519 aa) |
| | APRT | Adenine phosphoribosyltransferase. (180 aa) |
| | LOC108289796 | Thioredoxin domain-containing protein. (84 aa) |
| | GLRX2 | Glutaredoxin 2. (158 aa) |
| | ENTPD1 | Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (522 aa) |
| | TYMP | Thymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (482 aa) |
| | ENSCCAP00000029997 | Uncharacterized protein. (391 aa) |
| | HPRT1 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa) |
| | DALRD3 | DALR anticodon binding domain containing 3. (543 aa) |
| | PRTFDC1 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (225 aa) |
| | CMPK2 | Cytidine/uridine monophosphate kinase 2. (448 aa) |
| | AK5 | Adenylate kinase 5; Belongs to the adenylate kinase family. (562 aa) |
| | LOC108290368 | Nudix hydrolase domain-containing protein. (206 aa) |
| | LOC108308296 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (232 aa) |
| | DHODH | Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (367 aa) |
| | LOC108312238 | Nucleoside diphosphate kinase. (143 aa) |
| | NUDT15 | Nudix hydrolase 15. (164 aa) |
| | NME3 | Nucleoside diphosphate kinase. (169 aa) |
| | LOC108291935 | Uncharacterized protein. (217 aa) |
| | UMPS | Uridine monophosphate synthetase. (480 aa) |
| | LOC108310960 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa) |
| | GUK1 | Guanylate kinase 1. (235 aa) |
| | TYMS | Thymidylat_synt domain-containing protein. (313 aa) |
| | NME4 | Nucleoside diphosphate kinase. (187 aa) |
| | GMPR2 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (358 aa) |
| | XDH | Xanthine dehydrogenase. (1333 aa) |
| | PAICS | AIRC domain-containing protein. (453 aa) |
| | GLRX | Glutaredoxin. (106 aa) |
| | CAD | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2225 aa) |
| | NUDT18 | Nudix hydrolase 18; Belongs to the Nudix hydrolase family. (323 aa) |
| | CDADC1 | Cytidine and dCMP deaminase domain containing 1. (515 aa) |
| | IMPDH2 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa) |
| | QRICH1 | Glutamine rich 1. (777 aa) |
| | DGUOK | Deoxyguanosine kinase. (278 aa) |
| | GDA | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (472 aa) |
| | NUDT13 | Nudix hydrolase 13. (352 aa) |
| | DUT | Deoxyuridine triphosphatase. (250 aa) |
| | ENTPD8 | Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (494 aa) |
