STRINGSTRING
ENSCCAP00000000531 ENSCCAP00000000531 MED1 MED1 LOC108307291 LOC108307291 ENSCCAP00000001165 ENSCCAP00000001165 LOC108304381 LOC108304381 NCOA2 NCOA2 NCOA6 NCOA6 LOC108290168 LOC108290168 TFB1M TFB1M GLUD2 GLUD2 LOC108299683 LOC108299683 MEF2C MEF2C LOC108304643 LOC108304643 GABPB1 GABPB1 ESRRA ESRRA CARM1 CARM1 ENSCCAP00000006182 ENSCCAP00000006182 LOC108298753 LOC108298753 HCFC1 HCFC1 NRF1 NRF1 ENSCCAP00000008449 ENSCCAP00000008449 TWNK TWNK SMARCD3 SMARCD3 CRTC1 CRTC1 HDAC3 HDAC3 LOC108288636 LOC108288636 ENSCCAP00000011724 ENSCCAP00000011724 NCOA1 NCOA1 ENSCCAP00000013616 ENSCCAP00000013616 CREB1 CREB1 ALAS1 ALAS1 PPARGC1A PPARGC1A IDH2 IDH2 POLRMT POLRMT SOD2 SOD2 POLG2 POLG2 CREBBP CREBBP ATP5F1B ATP5F1B TBL1X TBL1X MTERF1 MTERF1 LOC108303234 LOC108303234 GLUD1 GLUD1 PPARGC1B PPARGC1B HELZ2 HELZ2 SIRT3 SIRT3 ENSCCAP00000020525 ENSCCAP00000020525 TFB2M TFB2M ENSCCAP00000022660 ENSCCAP00000022660 CAMK4 CAMK4 PPARA PPARA CRTC3 CRTC3 GABPA GABPA SIRT4 SIRT4 TGS1 TGS1 ACSS2 ACSS2 NR1D1 NR1D1 LOC108293847 LOC108293847 TBL1XR1 TBL1XR1 RXRA RXRA SRFBP1 SRFBP1 NCOR1 NCOR1 CRTC2 CRTC2 MEF2D MEF2D GABPB2 GABPB2 ATF2 ATF2 CHD9 CHD9 ENSCCAP00000037411 ENSCCAP00000037411 SIRT5 SIRT5 SSBP1 SSBP1 TFAM TFAM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCCAP00000000531Uncharacterized protein. (363 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa)
LOC108307291Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSCCAP00000001165Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (89 aa)
LOC108304381Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
NCOA6Nuclear receptor coactivator 6. (2057 aa)
LOC108290168Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TFB1MrRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (345 aa)
GLUD2Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (490 aa)
LOC108299683Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (106 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
LOC108304643NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (310 aa)
GABPB1GA binding protein transcription factor subunit beta 1. (395 aa)
ESRRAEstrogen related receptor alpha. (421 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (609 aa)
ENSCCAP00000006182Uncharacterized protein. (353 aa)
LOC108298753Uncharacterized protein. (242 aa)
HCFC1Host cell factor C1. (2080 aa)
NRF1Nuclear respiratory factor 1. (503 aa)
ENSCCAP00000008449Uncharacterized protein. (149 aa)
TWNKTwinkle mtDNA helicase. (684 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (475 aa)
CRTC1CREB regulated transcription coactivator 1. (650 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
LOC108288636Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (99 aa)
ENSCCAP00000011724Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (493 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
ENSCCAP00000013616Uncharacterized protein. (120 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ALAS15-aminolevulinate synthase. (550 aa)
PPARGC1APPARG coactivator 1 alpha. (812 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (433 aa)
POLRMTDNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family. (1264 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
POLG2DNA polymerase gamma 2, accessory subunit. (485 aa)
CREBBPCREB binding protein. (2448 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (518 aa)
TBL1XTransducin beta like 1 X-linked. (517 aa)
MTERF1Mitochondrial transcription termination factor 1. (393 aa)
LOC108303234Cytochrome c. (105 aa)
GLUD1ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (558 aa)
PPARGC1BPPARG coactivator 1 beta. (1021 aa)
HELZ2Helicase with zinc finger 2. (2644 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (398 aa)
ENSCCAP00000020525Uncharacterized protein. (330 aa)
TFB2MrRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (379 aa)
ENSCCAP00000022660Uncharacterized protein. (404 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
CRTC3CREB regulated transcription coactivator 3. (619 aa)
GABPAGA binding protein transcription factor subunit alpha. (454 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
TGS1Trimethylguanosine synthase 1. (870 aa)
ACSS2Acyl-CoA synthetase short chain family member 2. (715 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (615 aa)
LOC108293847Cytochrome c. (105 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (514 aa)
RXRARetinoid X receptor alpha. (455 aa)
SRFBP1BUD22 domain-containing protein. (429 aa)
NCOR1SANT domain-containing protein. (2281 aa)
CRTC2CREB regulated transcription coactivator 2. (620 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
GABPB2GA binding protein transcription factor subunit beta 2. (315 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
CHD9Chromodomain helicase DNA binding protein 9. (2882 aa)
ENSCCAP00000037411Uncharacterized protein. (145 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (309 aa)
SSBP1Uncharacterized protein. (148 aa)
TFAMTranscription factor A, mitochondrial. (249 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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