STRINGSTRING
FADD FADD TNFRSF10B TNFRSF10B TRADD TRADD FAS FAS TRAF2 TRAF2 CASP8 CASP8 TNFRSF10A TNFRSF10A RIPK1 RIPK1 TNFSF10 TNFSF10 CFLAR CFLAR FASLG FASLG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
TNFRSF10BTNF receptor superfamily member 10b. (443 aa)
TRADDTNFRSF1A associated via death domain. (312 aa)
FASFas cell surface death receptor. (317 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (522 aa)
TNFRSF10ATNF receptor superfamily member 10a. (419 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (281 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (281 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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