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FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) | ||||
TNFRSF10B | TNF receptor superfamily member 10b. (443 aa) | ||||
TRADD | TNFRSF1A associated via death domain. (312 aa) | ||||
FAS | Fas cell surface death receptor. (317 aa) | ||||
TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) | ||||
CASP8 | Caspase 8; Belongs to the peptidase C14A family. (522 aa) | ||||
TNFRSF10A | TNF receptor superfamily member 10a. (419 aa) | ||||
RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) | ||||
TNFSF10 | Tumor necrosis factor ligand superfamily member. (281 aa) | ||||
CFLAR | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa) | ||||
FASLG | Fas ligand; Belongs to the tumor necrosis factor family. (281 aa) |