STRINGSTRING
TBK1 TBK1 CASP8 CASP8 TNF TNF TRAF2 TRAF2 BIRC3 BIRC3 TNFAIP3 TNFAIP3 TRADD TRADD SPATA2 SPATA2 USP21 USP21 IKBKE IKBKE RBCK1 RBCK1 MIB2 MIB2 XIAP XIAP FADD FADD BIRC7 BIRC7 OTUD7B OTUD7B TNFRSF1A TNFRSF1A SHARPIN SHARPIN RNF31 RNF31 USP2 USP2 USP4 USP4 RIPK1 RIPK1 CYLD CYLD BIRC2 BIRC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TBK1TANK binding kinase 1. (729 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (522 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
TNFAIP3TNF alpha induced protein 3. (804 aa)
TRADDTNFRSF1A associated via death domain. (312 aa)
SPATA2Spermatogenesis associated 2. (520 aa)
USP21Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (565 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (510 aa)
MIB2Mindbomb E3 ubiquitin protein ligase 2. (966 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
BIRC7Baculoviral IAP repeat containing 7. (290 aa)
OTUD7BOTU deubiquitinase 7B. (843 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
SHARPINSHANK associated RH domain interactor. (386 aa)
RNF31Uncharacterized protein. (1072 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (610 aa)
USP4Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (959 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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