STRINGSTRING
TP63 TP63 LOC108307291 LOC108307291 LOC108284318 LOC108284318 ENSCCAP00000001165 ENSCCAP00000001165 LOC108304381 LOC108304381 LOC108290168 LOC108290168 LOC108299683 LOC108299683 CHMP2B CHMP2B LOC108290290 LOC108290290 ENSCCAP00000009063 ENSCCAP00000009063 ELANE ELANE LOC108288636 LOC108288636 BAX BAX CARD16 CARD16 CASP1 CASP1 CASP4 CASP4 CHMP4C CHMP4C GSDME GSDME LOC108303234 LOC108303234 ENSCCAP00000017906 ENSCCAP00000017906 IRF2 IRF2 LOC108310005 LOC108310005 MDP1 MDP1 GSDMD GSDMD HMGB1 HMGB1 CHMP7 CHMP7 IL1B IL1B NPVF NPVF CHMP6 CHMP6 LOC108293847 LOC108293847 CASP3 CASP3 CARD18 CARD18 TP53 TP53 ENSCCAP00000030160 ENSCCAP00000030160 GZMB GZMB CHMP2A CHMP2A CHMP4B CHMP4B IL1A IL1A LOC108306798 LOC108306798 IRF1 IRF1 IL18 IL18 BAK1 BAK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
LOC108307291Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC108284318Uncharacterized protein. (194 aa)
ENSCCAP00000001165Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (89 aa)
LOC108304381Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC108290168Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC108299683Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (106 aa)
CHMP2BCharged multivesicular body protein 2B. (215 aa)
LOC108290290HMG box domain-containing protein. (132 aa)
ENSCCAP00000009063Uncharacterized protein; Belongs to the peptidase C14A family. (265 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (265 aa)
LOC108288636Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (99 aa)
BAXBCL2 associated X, apoptosis regulator. (159 aa)
CARD16Caspase recruitment domain family member 16. (185 aa)
CASP1Uncharacterized protein; Belongs to the peptidase C14A family. (439 aa)
CASP4Caspase 4; Belongs to the peptidase C14A family. (377 aa)
CHMP4CCharged multivesicular body protein 4C. (233 aa)
GSDMEGasdermin E. (496 aa)
LOC108303234Cytochrome c. (105 aa)
ENSCCAP00000017906Uncharacterized protein. (188 aa)
IRF2Interferon regulatory factor. (349 aa)
LOC108310005Uncharacterized protein. (221 aa)
MDP1Magnesium dependent phosphatase 1. (164 aa)
GSDMDGasdermin D. (527 aa)
HMGB1Uncharacterized protein. (187 aa)
CHMP7Charged multivesicular body protein 7. (453 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
NPVFNeuropeptide VF precursor. (196 aa)
CHMP6Charged multivesicular body protein 6. (201 aa)
LOC108293847Cytochrome c. (105 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
CARD18Caspase recruitment domain family member 18. (91 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (395 aa)
ENSCCAP00000030160Uncharacterized protein. (185 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (247 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
CHMP4BCharged multivesicular body protein 4B. (224 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (225 aa)
LOC108306798Uncharacterized protein. (188 aa)
IRF1Interferon regulatory factor. (325 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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