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| | SUMO3 | Ubiquitin-like domain-containing protein. (133 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (570 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa) |
| | RFC5 | Replication factor C subunit 5. (387 aa) |
| | ENSCCAP00000040419 | Histone H2B; Belongs to the histone H2B family. (129 aa) |
| | RFC3 | Replication factor C subunit 3. (236 aa) |
| | LOC108300233 | Uncharacterized protein. (147 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (713 aa) |
| | POLH | DNA polymerase eta. (710 aa) |
| | KXD1 | KxDL motif containing 1. (194 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (156 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | ENSCCAP00000039561 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (135 aa) |
| | LOC108285592 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1312 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (329 aa) |
| | ENSCCAP00000038324 | Ubiquitin-like domain-containing protein. (117 aa) |
| | RFC2 | Rep_fac_C domain-containing protein. (209 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1369 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (415 aa) |
| | RNF4 | Uncharacterized protein. (89 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (534 aa) |
| | TIMELESS | Timeless circadian regulator. (1116 aa) |
| | RAD9B | RAD9 checkpoint clamp component B. (345 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (419 aa) |
| | RECQL4 | RecQ like helicase 4. (1211 aa) |
| | ENSCCAP00000035255 | Rad60-SLD domain-containing protein. (72 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | ENSCCAP00000034488 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (91 aa) |
| | SIRT7 | Sirtuin 7. (421 aa) |
| | ENSCCAP00000033351 | annotation not available (131 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) |
| | ENSCCAP00000032435 | Uncharacterized protein. (154 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | UBE2N | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3397 aa) |
| | ENSCCAP00000031654 | Histone H2B; Belongs to the histone H2B family. (142 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (321 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | ENSCCAP00000031131 | Uncharacterized protein. (267 aa) |
| | CDCA7 | zf-4CXXC_R1 domain-containing protein. (450 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa) |
| | RNF169 | Ring finger protein 169. (708 aa) |
| | RAD51C | RECA_2 domain-containing protein. (352 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1526 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | ENSCCAP00000030343 | Rad60-SLD domain-containing protein. (107 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4803 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (350 aa) |
| | SPIDR | DUF4503 domain-containing protein. (397 aa) |
| | ENSCCAP00000028938 | Uncharacterized protein. (79 aa) |
| | ENSCCAP00000028779 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (186 aa) |
| | UBE2V2 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa) |
| | LOC108298787 | Histone H4. (103 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (633 aa) |
| | ENSCCAP00000028012 | Uncharacterized protein. (307 aa) |
| | LOC108285114 | Ubiquitin-like domain-containing protein. (156 aa) |
| | LOC108298207 | Histone H4. (103 aa) |
| | ENSCCAP00000027518 | Ubiquitin-like domain-containing protein. (122 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (448 aa) |
| | LOC108298788 | Histone H4. (103 aa) |
| | POLD1 | DNA polymerase. (1105 aa) |
| | LOC108298786 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSCCAP00000027099 | Uncharacterized protein. (296 aa) |
| | ENSCCAP00000027088 | DUF4502 domain-containing protein. (204 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (543 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (391 aa) |
| | ENSCCAP00000026887 | Uncharacterized protein. (295 aa) |
| | ENSCCAP00000026853 | Ubiquitin-like domain-containing protein. (107 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (907 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (280 aa) |
| | SUMO2 | Small ubiquitin-related modifier. (80 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (719 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1179 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa) |
| | ENSCCAP00000024430 | Uncharacterized protein. (265 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | ENSCCAP00000024326 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (131 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (239 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (282 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (556 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (581 aa) |
| | POLK | DNA polymerase kappa. (863 aa) |
| | ENSCCAP00000022407 | Uncharacterized protein. (67 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3000 aa) |
| | LOC108310759 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa) |
| | ENSCCAP00000021037 | Ubiquitin-like domain-containing protein. (118 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1345 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (372 aa) |
| | ENSCCAP00000019982 | Rad60-SLD domain-containing protein. (74 aa) |
| | ENSCCAP00000019711 | Rad60-SLD domain-containing protein. (68 aa) |
| | ENSCCAP00000018808 | Uncharacterized protein. (68 aa) |
| | POLQ | DNA polymerase theta. (2324 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1830 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (484 aa) |
| | ENSCCAP00000016251 | Uncharacterized protein. (107 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1971 aa) |
| | ENSCCAP00000014916 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (133 aa) |
| | MEIOB | Meiosis specific with OB-fold. (455 aa) |
| | RPA3 | Uncharacterized protein. (121 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1212 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | LOC108298921 | Histone domain-containing protein; Belongs to the histone H2B family. (181 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1826 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1058 aa) |
| | LOC108317875 | RECA_2 domain-containing protein. (351 aa) |
| | ABL1 | Tyrosine-protein kinase. (1149 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (345 aa) |
| | ENSCCAP00000012432 | Rad60-SLD domain-containing protein. (54 aa) |
| | TDRD3 | Tudor domain containing 3. (744 aa) |
| | WRN | WRN RecQ like helicase. (1431 aa) |
| | ENSCCAP00000012006 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (193 aa) |
| | MDC1 | Mediator of DNA damage checkpoint 1. (1758 aa) |
| | ENSCCAP00000011833 | Histone H2B; Belongs to the histone H2B family. (129 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (498 aa) |
| | PPP4R2 | Protein phosphatase 4 regulatory subunit 2. (417 aa) |
| | ENSCCAP00000011005 | Ubiquitin-like domain-containing protein. (127 aa) |
| | BLM | BLM RecQ like helicase. (1401 aa) |
| | ENSCCAP00000010022 | Uncharacterized protein. (262 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (119 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1060 aa) |
| | RAD51B | RAD51 paralog B. (426 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | RAD51D | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (328 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (564 aa) |
| | EXO1 | Exonuclease 1. (847 aa) |
| | SIRT6 | Sirtuin 6. (382 aa) |
| | LOC108295790 | Histone domain-containing protein; Belongs to the histone H2B family. (175 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (778 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (552 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) |
| | CLSPN | Claspin. (1336 aa) |
| | LOC108301415 | Uncharacterized protein. (111 aa) |
| | PWWP2A | PWWP domain containing 2A. (755 aa) |
| | LOC108316498 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | POLD3 | DNA polymerase delta 3, accessory subunit. (464 aa) |
| | ENSCCAP00000005315 | UmuC domain-containing protein. (176 aa) |
| | LOC108297260 | Histone H2B type 1. (126 aa) |
| | ENSCCAP00000005142 | annotation not available (103 aa) |
| | LOC108304268 | Histone H4. (103 aa) |
| | ENSCCAP00000004930 | annotation not available (103 aa) |
| | ENSCCAP00000004623 | annotation not available (103 aa) |
| | RFC1 | Replication factor C subunit 1. (1122 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (409 aa) |
| | ENSCCAP00000004129 | annotation not available (103 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (899 aa) |
| | ENSCCAP00000003988 | Uncharacterized protein. (234 aa) |
| | ATRIP | ATR interacting protein. (790 aa) |
| | LOC108313418 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa) |
| | LOC108306503 | Ubiquitin-like domain-containing protein. (156 aa) |
| | ENSCCAP00000003596 | annotation not available (103 aa) |
| | ENSCCAP00000003507 | Uncharacterized protein. (78 aa) |
| | LOC108297261 | Histone H4. (103 aa) |
| | LOC108290397 | Ubiquitin-like domain-containing protein. (156 aa) |
| | ENSCCAP00000002896 | Uncharacterized protein. (240 aa) |
| | ENSCCAP00000002836 | annotation not available (103 aa) |
| | ENSCCAP00000002773 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (709 aa) |
| | ENSCCAP00000002159 | Rep_fac_C domain-containing protein. (306 aa) |
| | LOC108306916 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa) |
| | HIST1H4E | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC108287040 | Histone domain-containing protein; Belongs to the histone H2B family. (127 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (532 aa) |
| | UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | LOC108312590 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC108315963 | Ubiquitin-like domain-containing protein. (156 aa) |
| | LIG3 | DNA ligase. (1014 aa) |
| | LOC108287016 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSCCAP00000000680 | Uncharacterized protein. (253 aa) |
| | HIST1H2BO | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC108289618 | RING-type domain-containing protein. (182 aa) |
