(85 nodes) Pyruvate metabolism network (Cebus capucinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108295199	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (323 aa)
	ENSCCAP00000000279	Ldh_1_N domain-containing protein. (91 aa)
	LACTB2	Lactamase beta 2. (288 aa)
	ALDH1B1	Aldehyde dehydrogenase 1 family member B1; Belongs to the aldehyde dehydrogenase family. (517 aa)
	LOC108296889	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
	KIF25	Kinesin family member 25; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (340 aa)
	ACOT12	Acyl-CoA thioesterase 12. (554 aa)
	ALDH16A1	Aldehyde dehydrogenase family 16 member A1. (802 aa)
	LOC108298924	Malate dehydrogenase. (291 aa)
	ALDH3A2	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (508 aa)
	HAGHL	Hydroxyacylglutathione hydrolase like. (282 aa)
	GLOD4	Glyoxalase domain containing 4. (469 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2383 aa)
	PDHA1	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (409 aa)
	ACYP2	Acylphosphatase. (99 aa)
	KIFC1	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (549 aa)
	BBS1	BBS1 domain-containing protein. (593 aa)
	ENSCCAP00000006801	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (349 aa)
	ACAD11	Acyl-CoA dehydrogenase family member 11. (781 aa)
	ENSCCAP00000007270	Uncharacterized protein. (315 aa)
	SLC25A3	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (346 aa)
	CARTPT	CART prepropeptide. (116 aa)
	LOC108301874	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (481 aa)
	GRHPR	Glyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (336 aa)
	RNF138	Ring finger protein 138. (245 aa)
	ME3	Malic enzyme. (604 aa)
	TTLL12	Tubulin tyrosine ligase like 12. (645 aa)
	ENSCCAP00000011845	Uncharacterized protein; Belongs to the LDH/MDH superfamily. (277 aa)
	ACAT1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (425 aa)
	PDHB	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
	URB2	URB2 ribosome biogenesis homolog. (1552 aa)
	ME1	Malic enzyme. (572 aa)
	ENSCCAP00000012685	Acylphosphatase. (134 aa)
	MDH2	Malate dehydrogenase. (338 aa)
	HAGH	Hydroxyacylglutathione hydrolase. (318 aa)
	PKM	Pyruvate kinase; Belongs to the pyruvate kinase family. (539 aa)
	ACACB	Acetyl-CoA carboxylase beta. (2458 aa)
	DLD	Dihydrolipoyl dehydrogenase. (509 aa)
	NOP53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (478 aa)
	ENSCCAP00000015574	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (346 aa)
	LOC108311280	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (317 aa)
	LOC108297965	Pyruvate kinase; Belongs to the pyruvate kinase family. (471 aa)
	LDHD	Lactate dehydrogenase D. (484 aa)
	DLAT	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (649 aa)
	TMEM104	Transmembrane protein 104. (496 aa)
	KIFC3	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (848 aa)
	MBLAC2	Metallo-beta-lactamase domain containing 2. (279 aa)
	PCK2	Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
	ACAD10	Acyl-CoA dehydrogenase family member 10. (1089 aa)
	PKLR	Pyruvate kinase; Belongs to the pyruvate kinase family. (513 aa)
	KIFC2	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (793 aa)
	ENSCCAP00000021627	L-lactate dehydrogenase. (217 aa)
	TSR1	TSR1 ribosome maturation factor. (762 aa)
	MDH1B	Malate dehydrogenase 1B. (512 aa)
	LDHA	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
	ENSCCAP00000023364	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (353 aa)
	ENSCCAP00000023601	Ldh_1_N domain-containing protein. (178 aa)
	LOC108301202	Pyruvate kinase; Belongs to the pyruvate kinase family. (512 aa)
	ENSCCAP00000024393	Uncharacterized protein. (69 aa)
	PARP6	Poly [ADP-ribose] polymerase. (631 aa)
	ALDH7A1	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (554 aa)
	ACSS2	Acyl-CoA synthetase short chain family member 2. (715 aa)
	LDHAL6A	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
	LDHC	Lactate dehydrogenase C; Belongs to the LDH/MDH superfamily. (291 aa)
	FH	Fumarate hydratase. (510 aa)
	CLPTM1	CLPTM1 regulator of GABA type A receptor forward trafficking. (669 aa)
	LOC108314569	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (345 aa)
	ALDH2	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (517 aa)
	MDH1	Malate dehydrogenase. (343 aa)
	CLPTM1L	Uncharacterized protein. (537 aa)
	LOC108312582	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (324 aa)
	ME2	Malic enzyme. (503 aa)
	GLO1	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (184 aa)
	ACYP1	Acylphosphatase. (129 aa)
	PC	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1192 aa)
	ACSS1	Acetyl-coenzyme A synthetase. (688 aa)
	PNKD	PNKD metallo-beta-lactamase domain containing. (385 aa)
	LDHB	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	PARP8	Poly [ADP-ribose] polymerase. (853 aa)
	ENSCCAP00000035313	L-lactate dehydrogenase. (252 aa)
	ACOT11	Acyl-CoA thioesterase 11. (594 aa)
	LOC108302977	E1_dh domain-containing protein. (358 aa)
	ALDH9A1	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (457 aa)
	ACAT2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)

Your Current Organism:

Cebus capucinus

NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ACACB	ENSCCAP00000004979	ENSCCAP00000014502	Acetyl-CoA carboxylase alpha.	Acetyl-CoA carboxylase beta.	0.952
ACACA	ACAT1	ENSCCAP00000004979	ENSCCAP00000011902	Acetyl-CoA carboxylase alpha.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.916
ACACA	ACAT2	ENSCCAP00000004979	ENSCCAP00000032091	Acetyl-CoA carboxylase alpha.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.960
ACACA	ACOT11	ENSCCAP00000004979	ENSCCAP00000034828	Acetyl-CoA carboxylase alpha.	Acyl-CoA thioesterase 11.	0.408
ACACA	ACOT12	ENSCCAP00000004979	ENSCCAP00000001586	Acetyl-CoA carboxylase alpha.	Acyl-CoA thioesterase 12.	0.885
ACACA	ACSS1	ENSCCAP00000004979	ENSCCAP00000039309	Acetyl-CoA carboxylase alpha.	Acetyl-coenzyme A synthetase.	0.923
ACACA	ACSS2	ENSCCAP00000004979	ENSCCAP00000026439	Acetyl-CoA carboxylase alpha.	Acyl-CoA synthetase short chain family member 2.	0.963
ACACA	CARTPT	ENSCCAP00000004979	ENSCCAP00000007951	Acetyl-CoA carboxylase alpha.	CART prepropeptide.	0.577
ACACA	DLAT	ENSCCAP00000004979	ENSCCAP00000017420	Acetyl-CoA carboxylase alpha.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.897
ACACA	GRHPR	ENSCCAP00000004979	ENSCCAP00000009088	Acetyl-CoA carboxylase alpha.	Glyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.647
ACACA	ME1	ENSCCAP00000004979	ENSCCAP00000012435	Acetyl-CoA carboxylase alpha.	Malic enzyme.	0.539
ACACA	ME2	ENSCCAP00000004979	ENSCCAP00000031498	Acetyl-CoA carboxylase alpha.	Malic enzyme.	0.539
ACACA	ME3	ENSCCAP00000004979	ENSCCAP00000010572	Acetyl-CoA carboxylase alpha.	Malic enzyme.	0.539
ACACA	PC	ENSCCAP00000004979	ENSCCAP00000039694	Acetyl-CoA carboxylase alpha.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.797
ACACA	PCK1	ENSCCAP00000004979	ENSCCAP00000036756	Acetyl-CoA carboxylase alpha.	Phosphoenolpyruvate carboxykinase 1.	0.611
ACACA	PCK2	ENSCCAP00000004979	ENSCCAP00000018527	Acetyl-CoA carboxylase alpha.	Phosphoenolpyruvate carboxykinase 2, mitochondrial.	0.560
ACACA	PDHB	ENSCCAP00000004979	ENSCCAP00000012239	Acetyl-CoA carboxylase alpha.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.536
ACACA	PKLR	ENSCCAP00000004979	ENSCCAP00000020051	Acetyl-CoA carboxylase alpha.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.441
ACACB	ACACA	ENSCCAP00000014502	ENSCCAP00000004979	Acetyl-CoA carboxylase beta.	Acetyl-CoA carboxylase alpha.	0.952
ACACB	ACAT1	ENSCCAP00000014502	ENSCCAP00000011902	Acetyl-CoA carboxylase beta.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.916