STRINGSTRING
SLF1 SLF1 POLD1 POLD1 SASS6 SASS6 ATRX ATRX RPA2 RPA2 LOC108317875 LOC108317875 SUGP1 SUGP1 POLD2 POLD2 SUGP2 SUGP2 DDX52 DDX52 BLM BLM ENSCCAP00000010022 ENSCCAP00000010022 RAD51B RAD51B RAD51 RAD51 RAD51D RAD51D DMC1 DMC1 SAP130 SAP130 BARD1 BARD1 TOP3B TOP3B MUS81 MUS81 LOC108301415 LOC108301415 PWWP2A PWWP2A POLD3 POLD3 STN1 STN1 SYCP3 SYCP3 POLD4 POLD4 ABRAXAS1 ABRAXAS1 FICD FICD PPIL3 PPIL3 RBBP8 RBBP8 ENSCCAP00000003988 ENSCCAP00000003988 CNP CNP ENSCCAP00000000393 ENSCCAP00000000393 ENSCCAP00000000680 ENSCCAP00000000680 ABRAXAS2 ABRAXAS2 PRKRIP1 PRKRIP1 RPA1 RPA1 FSBP FSBP MRE11 MRE11 YJU2 YJU2 MEIOB MEIOB RPA3 RPA3 FAM9B FAM9B BRIP1 BRIP1 ENSCCAP00000013616 ENSCCAP00000013616 RAD54L RAD54L UNC93A UNC93A ENSCCAP00000016251 ENSCCAP00000016251 LOC108287552 LOC108287552 BRCA1 BRCA1 LOC108314072 LOC108314072 MCPH1 MCPH1 MCFD2 MCFD2 SLC4A1AP SLC4A1AP MPHOSPH9 MPHOSPH9 ATM ATM ENSCCAP00000022407 ENSCCAP00000022407 EME1 EME1 GTF3C6 GTF3C6 ENSCCAP00000024430 ENSCCAP00000024430 N4BP2L1 N4BP2L1 TOP3A TOP3A TM6SF2 TM6SF2 PALB2 PALB2 UIMC1 UIMC1 XRCC2 XRCC2 ENSCCAP00000026582 ENSCCAP00000026582 ENSCCAP00000026887 ENSCCAP00000026887 ENSCCAP00000027099 ENSCCAP00000027099 BRCA2 BRCA2 UNC93B1 UNC93B1 N4BP2 N4BP2 RECQL4 RECQL4 RAD52 RAD52 LURAP1 LURAP1 BABAM2 BABAM2 ENSCCAP00000037411 ENSCCAP00000037411 N4BP2L2 N4BP2L2 HELQ HELQ BABAM1 BABAM1 SSBP1 SSBP1 RAD50 RAD50 PITHD1 PITHD1 XRCC3 XRCC3 SEM1-2 SEM1-2 C12orf66 C12orf66 ENSCCAP00000028012 ENSCCAP00000028012 RECQL5 RECQL5 TOPBP1 TOPBP1 RAD51C RAD51C PIF1 PIF1 ENSCCAP00000031131 ENSCCAP00000031131 NBN NBN BRCC3 BRCC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLF1SMC5-SMC6 complex localization factor 1. (1058 aa)
POLD1DNA polymerase. (1105 aa)
SASS6SAS-6 centriolar assembly protein. (657 aa)
ATRXATRX chromatin remodeler. (2240 aa)
RPA2Replication protein A2. (339 aa)
LOC108317875RECA_2 domain-containing protein. (351 aa)
SUGP1SURP and G-patch domain containing 1. (645 aa)
POLD2DNA polymerase delta 2, accessory subunit. (498 aa)
SUGP2SURP and G-patch domain containing 2. (1099 aa)
DDX52DExD-box helicase 52. (599 aa)
BLMBLM RecQ like helicase. (1401 aa)
ENSCCAP00000010022Uncharacterized protein. (262 aa)
RAD51BRAD51 paralog B. (426 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
RAD51DDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (328 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (311 aa)
SAP130SAP130_C domain-containing protein. (1083 aa)
BARD1BRCA1 associated RING domain 1. (778 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (726 aa)
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
LOC108301415Uncharacterized protein. (111 aa)
PWWP2APWWP domain containing 2A. (755 aa)
POLD3DNA polymerase delta 3, accessory subunit. (464 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
SYCP3Cor1 domain-containing protein. (236 aa)
POLD4Uncharacterized protein. (107 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (409 aa)
FICDFIC domain containing. (458 aa)
PPIL3Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (180 aa)
RBBP8RB binding protein 8, endonuclease. (899 aa)
ENSCCAP00000003988Uncharacterized protein. (234 aa)
CNP2',3'-cyclic nucleotide 3' phosphodiesterase. (474 aa)
ENSCCAP00000000393Uncharacterized protein. (145 aa)
ENSCCAP00000000680Uncharacterized protein. (253 aa)
ABRAXAS2Abraxas 2, BRISC complex subunit. (424 aa)
PRKRIP1PRKR interacting protein 1. (185 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa)
FSBPUncharacterized protein. (908 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (709 aa)
YJU2YJU2 splicing factor homolog. (309 aa)
MEIOBMeiosis specific with OB-fold. (455 aa)
RPA3Uncharacterized protein. (121 aa)
FAM9BFamily with sequence similarity 9 member B. (187 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1212 aa)
ENSCCAP00000013616Uncharacterized protein. (120 aa)
RAD54LRAD54 like. (747 aa)
UNC93AUnc-93 homolog A. (457 aa)
ENSCCAP00000016251Uncharacterized protein. (107 aa)
LOC108287552Cor1 domain-containing protein. (217 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1830 aa)
LOC108314072SAP130_C domain-containing protein. (906 aa)
MCPH1Microcephalin 1. (841 aa)
MCFD2Multiple coagulation factor deficiency 2. (146 aa)
SLC4A1APSolute carrier family 4 member 1 adaptor protein. (742 aa)
MPHOSPH9M-phase phosphoprotein 9. (991 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3000 aa)
ENSCCAP00000022407Uncharacterized protein. (67 aa)
EME1Essential meiotic structure-specific endonuclease 1. (581 aa)
GTF3C6General transcription factor IIIC subunit 6. (212 aa)
ENSCCAP00000024430Uncharacterized protein. (265 aa)
N4BP2L1NEDD4 binding protein 2 like 1. (241 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa)
TM6SF2Transmembrane 6 superfamily member 2. (377 aa)
PALB2Partner and localizer of BRCA2. (1179 aa)
UIMC1Ubiquitin interaction motif containing 1. (719 aa)
XRCC2X-ray repair cross complementing 2. (280 aa)
ENSCCAP00000026582Cor1 domain-containing protein. (249 aa)
ENSCCAP00000026887Uncharacterized protein. (295 aa)
ENSCCAP00000027099Uncharacterized protein. (296 aa)
BRCA2BRCA2 DNA repair associated. (3397 aa)
UNC93B1Unc-93 homolog B1, TLR signaling regulator. (597 aa)
N4BP2NEDD4 binding protein 2. (1770 aa)
RECQL4RecQ like helicase 4. (1211 aa)
RAD52RAD52 homolog, DNA repair protein. (419 aa)
LURAP1Leucine rich adaptor protein 1. (239 aa)
BABAM2BRISC and BRCA1 A complex member 2. (415 aa)
ENSCCAP00000037411Uncharacterized protein. (145 aa)
N4BP2L2NEDD4 binding protein 2 like 2. (750 aa)
HELQHelicase, POLQ like. (1100 aa)
BABAM1BRISC and BRCA1 A complex member 1. (329 aa)
SSBP1Uncharacterized protein. (148 aa)
RAD50Zinc-hook domain-containing protein. (1312 aa)
PITHD1PITH domain containing 1. (211 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa)
SEM1-2Uncharacterized protein. (88 aa)
C12orf66Chromosome 12 open reading frame 66. (468 aa)
ENSCCAP00000028012Uncharacterized protein. (307 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (990 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1526 aa)
RAD51CRECA_2 domain-containing protein. (352 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (708 aa)
ENSCCAP00000031131Uncharacterized protein. (267 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa)
BRCC3BRCA1/BRCA2-containing complex subunit 3. (321 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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