STRINGSTRING
ERCC4 ERCC4 RAD51C RAD51C BRCA2 BRCA2 FANCE FANCE PMS2 PMS2 N4BP2 N4BP2 FANCG FANCG WDR48 WDR48 FANCD2 FANCD2 N4BP2L2 N4BP2L2 CENPS CENPS FAAP24 FAAP24 HES1 HES1 ATR ATR POLH POLH PITHD1 PITHD1 LOC108300233 LOC108300233 FAAP100 FAAP100 POLI POLI BRCA1 BRCA1 ENSCCAP00000000534 ENSCCAP00000000534 RPA1 RPA1 SLX1A SLX1A CNP CNP ATRIP ATRIP ERCC1 ERCC1 MICAL1 MICAL1 MLH1 MLH1 ENSCCAP00000005315 ENSCCAP00000005315 LOC108301415 LOC108301415 MUS81 MUS81 TOP3B TOP3B RAD51 RAD51 CENPX CENPX BLM BLM TELO2 TELO2 MICALCL MICALCL LOC108317875 LOC108317875 SLX4 SLX4 BRIP1 BRIP1 ENSCCAP00000014053 ENSCCAP00000014053 MICAL2 MICAL2 RPA3 RPA3 ENSCCAP00000014781 ENSCCAP00000014781 RPA2 RPA2 FANCA FANCA TENT2 TENT2 SASS6 SASS6 FANCI FANCI ENSCCAP00000016251 ENSCCAP00000016251 MICAL3 MICAL3 POLN POLN POLQ POLQ FANCM FANCM FANCC FANCC FANCB FANCB REV1 REV1 NUTF2 NUTF2 EME2 EME2 ENSCCAP00000021044 ENSCCAP00000021044 FANCL FANCL FAN1 FAN1 ENSCCAP00000022407 ENSCCAP00000022407 POLK POLK EME1 EME1 REV3L REV3L N4BP2L1 N4BP2L1 TOP3A TOP3A PALB2 PALB2 ENSCCAP00000026382 ENSCCAP00000026382 USP1 USP1 UBE2T UBE2T HES4 HES4 ENSCCAP00000028938 ENSCCAP00000028938
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
RAD51CRECA_2 domain-containing protein. (352 aa)
BRCA2BRCA2 DNA repair associated. (3397 aa)
FANCEFA complementation group E. (536 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (862 aa)
N4BP2NEDD4 binding protein 2. (1770 aa)
FANCGFA complementation group G. (622 aa)
WDR48WD repeat domain 48. (684 aa)
FANCD2FA complementation group D2. (1442 aa)
N4BP2L2NEDD4 binding protein 2 like 2. (750 aa)
CENPSCentromere protein S. (138 aa)
FAAP24FA core complex associated protein 24. (215 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
POLHDNA polymerase eta. (710 aa)
PITHD1PITH domain containing 1. (211 aa)
LOC108300233Uncharacterized protein. (147 aa)
FAAP100FA core complex associated protein 100. (880 aa)
POLIDNA polymerase iota. (738 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1830 aa)
ENSCCAP00000000534NTF2 domain-containing protein. (137 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa)
CNP2',3'-cyclic nucleotide 3' phosphodiesterase. (474 aa)
ATRIPATR interacting protein. (790 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa)
MICAL1Microtubule associated monooxygenase, calponin and LIM domain containing 1. (1172 aa)
MLH1MutL homolog 1. (757 aa)
ENSCCAP00000005315UmuC domain-containing protein. (176 aa)
LOC108301415Uncharacterized protein. (111 aa)
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (726 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
CENPXUncharacterized protein. (81 aa)
BLMBLM RecQ like helicase. (1401 aa)
TELO2Telomere maintenance 2. (837 aa)
MICALCLBMERB domain-containing protein. (686 aa)
LOC108317875RECA_2 domain-containing protein. (351 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1826 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1212 aa)
ENSCCAP00000014053DNA_pol_B domain-containing protein. (262 aa)
MICAL2Microtubule associated monooxygenase, calponin and LIM domain containing 2. (1123 aa)
RPA3Uncharacterized protein. (121 aa)
ENSCCAP00000014781NTF2 domain-containing protein. (110 aa)
RPA2Replication protein A2. (339 aa)
FANCAFA complementation group A. (1436 aa)
TENT2Terminal nucleotidyltransferase 2. (484 aa)
SASS6SAS-6 centriolar assembly protein. (657 aa)
FANCIFA complementation group I. (1317 aa)
ENSCCAP00000016251Uncharacterized protein. (107 aa)
MICAL3Microtubule associated monooxygenase, calponin and LIM domain containing 3. (1996 aa)
POLNDNA polymerase nu. (879 aa)
POLQDNA polymerase theta. (2324 aa)
FANCMFA complementation group M. (1992 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (558 aa)
FANCBFA complementation group B. (859 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1254 aa)
NUTF2Nuclear transport factor 2. (127 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (372 aa)
ENSCCAP00000021044USP domain-containing protein; Belongs to the peptidase C19 family. (289 aa)
FANCLFA complementation group L. (380 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1016 aa)
ENSCCAP00000022407Uncharacterized protein. (67 aa)
POLKDNA polymerase kappa. (863 aa)
EME1Essential meiotic structure-specific endonuclease 1. (581 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (2752 aa)
N4BP2L1NEDD4 binding protein 2 like 1. (241 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa)
PALB2Partner and localizer of BRCA2. (1179 aa)
ENSCCAP00000026382USP domain-containing protein. (157 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (783 aa)
UBE2TUbiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (197 aa)
HES4Hes family bHLH transcription factor 4. (222 aa)
ENSCCAP00000028938Uncharacterized protein. (79 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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